Nitroblue tetrazolium | 7695-60-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Nitroblue tetrazolium
• 英文别名: 2-[2-methoxy-4-[3-methoxy-4-[3-(4-nitrophenyl)-5-phenyltetrazol-3-ium-2-yl]phenyl]phenyl]-3-(4-nitrophenyl)-5-phenyltetrazol-3-ium
• CAS: 7695-60-5
• 化学式: C40H30N10O6+2
• 分子量: 746.7
• InChiKey: JPXMTWWFLBLUCD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  12
• 重原子数：
  56
• 可旋转键数：
  9
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  179
• 氢给体数：
  0
• 氢受体数：
  10

ADMET

毒理性

• 副作用

神经毒素 - 其他中枢神经系统神经毒素

Neurotoxin - Other CNS neurotoxin

来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

反应信息

• 作为反应物：
  描述：

  Nitroblue tetrazolium 、 5-Bromo-4-chloro-3-indolyl phosphate 、 4-nitrophenyl phosphate 在 三羟甲基氨基甲烷盐酸盐 、 氯化镁 作用下， 生成 对硝基苯酚
  参考文献：
  名称：

  Method for distinguishing normal and cancer cells

  摘要：

  描述了一种选举核DNA的存在或缺失的方法。将细胞与包含DNA聚合酶I、DNase I和核苷酸dATP、dCTP、dGTP和dTTP或dUTP的反应组分反应，其中至少一种核苷酸被生物素标记。检测到生物素标记核苷酸并与暴露的DNA结合。还描述了一种用于检测细胞中暴露的DNA存在或缺失的试剂盒。

  公开号：

  US05264343A1

文献信息

• Method for detecting Candida on skin
  申请人：Martin Stephanie

  公开号：US20080057532A1

  公开（公告）日：2008-03-06

  A method and system for rapidly detecting Candida on the skin of a host, such as an infant with diaper rash, is provided. The method includes contacting a dermal sample with a colorant that exhibits a certain spectral response (e.g., color change) in the presence of Candida . For example, the colorant may change from a first color to a second color, from colorless to a color, or from a color to colorless. The colorant is typically capable of differentiating between Candida (e.g., Candida albicans ) and other microorganisms commonly associated with diaper rash, such as S. aureus and E. coli . Thus, when a dermal sample is placed into contact with the colorant, the color change may simply be observed to determine whether the infection is caused by Candida . If the color change occurs to a certain extent (e.g., from yellow to bright red), it may be determined that the test sample contains Candida . Likewise, if a color change occurs to a lesser extent (e.g., from yellow to faint orange) or not at all, it may be determined that the dermal sample contains other microorganisms (e.g., S. aureus or E. coli ), no infection is present, or that the infection is simply due to other causes. Regardless, it will become readily apparent whether or not treatment for Candida is needed.
• Array for rapid detection of a microorganism
  申请人：Martin Stephanie M.

  公开号：US20080057533A1

  公开（公告）日：2008-03-06

  A method for detecting a microorganism or class of microorganisms is provided. More specifically, the method employs an array that contains a plurality of discrete regions (referred to as “addresses”) spaced apart on a solid support in a predetermined pattern. The addresses are selected so that the array provides a distinct spectral response (e.g., pattern of colors) or “fingerprint” for a particular microorganism or class of microorganisms. For example, the array may provide a certain spectral response in the presence of one microorganism or class of microorganisms (e.g., gram-negative bacteria), but provide a completely different spectral response in the presence of another microorganism or class of microorganisms (e.g., gram-positive bacteria). Detection of the spectral response provided by the array may thus allow for differentiation between microorganisms.
• Skin coating with microbial indicator
  申请人：MacDonald John Gavin

  公开号：US20080145316A1

  公开（公告）日：2008-06-19

  Skin sealants are usually applied over skin preps to seal the skin and hold any remaining bacteria in place prior to surgical incisions. This sealant is generally left on the skin after surgery. A skin coating is provided that has an indicator that gives a visible color change upon contact with microbes or microbial by-products and so provides an early warning of infection. The coating is a curable coating composition that may also be used without skin preps and may be used to protect other disruptions in the skin like wounds, bruises, abrasions, burns, acne, blisters, bites, stings, punctures and cuts. It may also be used to close wounds or provide an additional barrier to other parts of the skin, such as the nails and mucosa.
• Array for Rapid Detection of a Microorganism
  申请人：Martin Stephanie M.

  公开号：US20090221061A1

  公开（公告）日：2009-09-03

  A method for detecting a microorganism or class of microorganisms is provided. More specifically, the method employs an array that contains a plurality of discrete regions (referred to as “addresses”) spaced apart on a solid support in a predetermined pattern. The addresses are selected so that the array provides a distinct spectral response (e.g., pattern of colors) or “fingerprint” for a particular microorganism or class of microorganisms. For example, the array may provide a certain spectral response in the presence of one microorganism or class of microoryanisms (e.g., gram-negative bacteria), but provide a completely different spectral response in the presence of another microorganism or class of microorganisms (e.g., gram-positive bacteria). Detection of the spectral response provided by the array may thus allow for differentiation between microorganisms.
• Method for Detecting Candida on Skin
  申请人：Martin Stephanie M.

  公开号：US20100291670A1

  公开（公告）日：2010-11-18

  A method and system for rapidly detecting Candida on the skin of a host, such as an infant with diaper rash, is provided. The method includes contacting a dermal sample with a colorant that exhibits a certain spectral response (e.g., color change) in the presence of Candida . For example, the colorant may change from a first color to a second color, from colorless to a color, or from a color to colorless. The colorant is typically capable of differentiating between Candida (e.g., Candida albicans ) and other microorganisms commonly associated with diaper rash, such as S. aureus and E. coli . Thus, when a dermal sample is placed into contact with the colorant, the color change may simply be observed to determine whether the infection is caused by Candida . If the color change occurs to a certain extent (e.g., from yellow to bright red), it may be determined that the test sample contains Candida . Likewise, if a color change occurs to a lesser extent (e.g., from yellow to faint orange) or not at all, it may be determined that the dermal sample contains other microorganisms (e.g., S. aureus or E. coli ), no infection is present, or that the infection is simply due to other causes. Regardless, it will become readily apparent whether or not treatment for Candida is needed.