Azanium;azane;dihydrogen phosphate

• 分子结构分类: 无机化合物 - 均质非金属化合物 - 非金属氧阴离子化合物
• 英文名称: Azanium;azane;dihydrogen phosphate
• 英文别名: azanium;azane;dihydrogen phosphate
• 化学式: H9N2O4P
• 分子量: 132.06
• InChiKey: MNNHAPBLZZVQHP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.44
• 重原子数：
  7
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  85.4
• 氢给体数：
  3
• 氢受体数：
  4

ADMET

代谢

在动物体内，二磷酸是由腺苷三磷酸（ATP）在许多酶促反应中形成的。它要么通过进入磷酸解反应被利用，要么被无机二磷酸酶水解成单磷酸。/二磷酸/

In the animal body, diphosphate is formed from adenosyl triphosphate (ATP) in many enzymatic reactions. It is either utilized by entering phosphorolytic reactions, or it is hydrolysed by an inorganic diposphatase to monophosphate. /Diphosphate/

来源:Hazardous Substances Data Bank (HSDB)

代谢

磷酸盐代谢缺陷发生在多种疾病中。...佝偻病...骨软化症...原发性或继发性甲状旁腺功能亢进...慢性肾衰竭。/磷酸盐/

A defect in phosphate metabolism occurs in a variety of diseases. ... Rickets ... Osteomalacia ... Primary or Secondary Hyperparathyroidism ... Chronic Renal Failure. /Phosphates/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 暴露途径

该物质可以通过吸入其气溶胶被吸收进入人体。

The substance can be absorbed into the body by inhalation of its aerosol.

来源:ILO-WHO International Chemical Safety Cards (ICSCs)

毒理性

• 眼睛症状

红斑。疼痛。

Redness. Pain.

来源:ILO-WHO International Chemical Safety Cards (ICSCs)

毒理性

• 副作用

皮肤致敏剂 - 一种可以诱导皮肤产生过敏反应的制剂。

Skin Sensitizer - An agent that can induce an allergic reaction in the skin.

来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

毒理性

• 相互作用

这篇论文总结了涉及香烟成瘾和依赖的因素。例如，烟草行业对尼古丁进行了深入研究，以了解其在最低可能浓度下的成瘾效果。添加二氨磷酸和尿素会使香烟烟雾的pH值呈碱性，从而促进尼古丁的吸收和跨膜传递。烟的口味、气味以及香烟包装的视觉外观也是促进成瘾的感官因素。最后，添加到香烟中的薄荷醇、糖、可可和甘草也在依赖和成瘾中发挥作用，例如，通过对呼吸道产生麻醉效果。

This paper summarizes data on the factors involved in addiction and dependence to cigarettes. Nicotine has been intensively studied by the tobacco industry, for instance for its addictive effect at the lowest possible rates. The addition of diammonium phosphate and urea produces an alcalinization of the pH of cigarette smoke, and promotes the absorption and the trans-membrane passage of nicotine. The taste, the smell of smoke, and the visual aspect of the pack of cigarettes are also sensory components that promote addiction. Finally, menthol, sugar, cocoa and liquorice added to cigarettes also play a role in dependence and addiction to cigarettes by, for instance, making an anesthetic effect on the airways.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

/SRP:/ 紧急急救：确保已经进行了充分的中和。如果患者停止呼吸，请开始人工呼吸，最好使用需求阀复苏器、袋阀面罩装置或口袋面罩，按训练操作。如有必要，执行心肺复苏。立即用缓慢流动的水冲洗受污染的眼睛。不要催吐。如果发生呕吐，让患者前倾或将其置于左侧（如果可能的话，头部向下）以保持呼吸道畅通，防止吸入。保持患者安静，维持正常体温。寻求医疗帮助。 /氨及其相关化合物/

/SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Ammonia and related compounds/

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

摄入的二磷酸盐很容易转化为单磷酸盐；在接受含有高达5%四钠二磷酸盐饮食的大鼠粪便或尿液中没有发现二磷酸盐。在这些实验中，二磷酸盐几乎完全被肠道吸收并以单磷酸盐的形式从尿液中排出。/二磷酸盐/

Ingested diphosphate is readily converted to monophosphate; no diphosphate was found in feces or urine of rats treated with diets containing up to 5% tetrasodium diphosphate. In these experiments diphosphate was almost completely absorbed by the gut and excreted as monophosphate in the urine. /Diphosphate/

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

磷酸盐从胃肠道被吸收，并在一定程度上被分泌到胃肠道中。磷酸盐从肠腔中的运输是一个积极的、依赖能量的过程，这个过程会受到多种因素的影响。... 维生素D刺激磷酸盐的吸收，据报道，这种效果先于它对钙离子运输的作用。在成年人中，大约三分之二的摄入磷酸盐被吸收，而被吸收的几乎全部通过尿液排出。在成长中的儿童中，磷酸盐的平衡是正的。儿童血浆中磷酸盐的浓度高于成年人。这种“高磷酸盐血症”降低了血红蛋白对氧气的亲和力，据推测，这解释了儿童生理上的“贫血”。/磷酸盐/

/Ortho/ phosphate is absorbed from, and to a limited extent secreted into, the gastrointestinal tract. Transport of phosphate from the gut lumen is an active, energy-dependent process that is modified by several factors. ... Vitamin D stimulates phosphate absorption, an effect reported to precede its action on calcium ion transport. In adults, about two thirds of the ingested phosphate is absorbed, and that which is absorbed is almost entirely excreted into the urine. In growing children, phosphate balance is positive. Concentrations of phosphate in plasma are higher in children than in adults. This "hyperphosphatemia" decreases the affinity of hemoglobin for oxygen and is hypothesized to explain the physiological "anemia" of childhood. /Phosphates/

来源:Hazardous Substances Data Bank (HSDB)

反应信息

• 作为反应物：
  描述：

  Azanium;azane;dihydrogen phosphate 生成 decacalcium;dihydroxide;hexaphosphate
  参考文献：
  名称：

  SIMONS, BRUNO;KASPERK, CHRISTIAN;EWERS, ROLF

  摘要：

  DOI：
• 作为产物：
  描述：

  反-2-丁烯 生成 Azanium;azane;dihydrogen phosphate
  参考文献：
  名称：

  KUKES, S.;NOWACK, G. P.;JOHNSON, M. M.

  摘要：

  DOI：
• 作为试剂：
  描述：

  葡萄糖 、 5-(1-hydroxyethyl) furo[2,3-c]pyridine 在 Azanium;azane;dihydrogen phosphate 、 potassium dihydrogenphosphate 、 magnesium;sulfate;heptahydrate 、 Zinc Sulfate Heptahydrate 、 (hexaaqua)iron(II) sulfate monohydrate 、 Copper sulfate pentahydrate 、 四水硫酸锰 、 氯化钠 、 葡萄糖 、 1-(呋喃并[2,3-c]吡啶-5-基)乙酮 作用下， 反应 98.33h， 生成 1-(呋喃并[2,3-c]吡啶-5-基)乙酮
  参考文献：
  名称：

  Enzyme for producing optically active pyridineethanol derivatives

  摘要：

  本发明涉及一种制备光学活性吡啶乙醇衍生物的方法。更具体地说，它涉及一种通过使酶或酶源作用于多环乙酰吡啶衍生物而制备光学活性多环吡啶乙醇衍生物的方法。本发明还涉及一种新的酶，可用于上述生产方法，编码该酶的DNA，具有该DNA的重组载体，以及具有该重组载体的转化体。本发明还涉及一种通过使上述新酶或上述转化体作用于光学不活性多环吡啶乙醇衍生物而制备光学活性多环吡啶乙醇衍生物的方法。

  公开号：

  US07329518B2

文献信息

• Calcitonin gene related peptide receptor antagonists
  申请人：——

  公开号：US20040204397A1

  公开（公告）日：2004-10-14

  The present invention relates to compounds of Formula (I) 1 as antagonists of calcitonin gene-related peptide receptors (“CGRP-receptor”), pharmaceutical compositions comprising them, methods for identifying them, methods of treatment using them and their use in therapy for treatment of neurogenic vasodilation, neurogenic inflammation, migraine and other headaches, thermal injury, circulatory shock, flushing associated with menopause, airway inflammatory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), and other conditions the treatment of which can be effected by the antagonism of CGRP-receptors.

  本发明涉及公式（I）1的化合物，作为降钙素基因相关肽受体（“CGRP受体”）的拮抗剂，包括它们的制药组合物，鉴定它们的方法，使用它们进行治疗的方法以及它们在治疗神经源性血管扩张、神经源性炎症、偏头痛和其他头痛、热损伤、循环性休克、更年期潮热、气道炎症性疾病（如哮喘和慢性阻塞性肺疾病（COPD））和其他可以通过CGRP受体拮抗治疗的疾病的治疗中的用途。
• Surgical cement from amorphous tricalcium phosphate, poly(carboxylic
  申请人：Meishintoryo Co. Ltd.

  公开号：US04684673A1

  公开（公告）日：1987-08-04

  Here disclosed are surgical cements useful for filling defect parts and vacant part of bones and teeth, which comprises (a) self-hardening amorphous tricalcium phosphate powder, (b) a component (B) of a surgically acceptable water-soluble poly(carboxylic acid), and (c) water and which is prepared by mixing amorphous tricalcium phosphate powder, the component (B) and water or mixing amorphous tricalcium phosphate and an aqueous solution of the component (B), then kneading the mixture.

  本发明公开了一种用于填补骨骼和牙齿缺陷部位和空缺部位的手术水泥，其包括(a)自硬化非晶三钙磷酸盐粉末，(b)手术可接受的水溶性聚（羧酸）组分(B)，以及(c)水，通过混合非晶三钙磷酸盐粉末、组分(B)和水，或混合非晶三钙磷酸盐和组分(B)的水溶液，然后揉合混合物制备而成。
• Whitlockite ceramic
  申请人：Sterling Drug Inc.

  公开号：US04195366A1

  公开（公告）日：1980-04-01

  A novel, polycrystalline whitlockite ceramic in either pore-free or porous form, processes for the preparation thereof and methods of using the same as biological implant materials are disclosed.

  本发明公开了一种新型的多晶白莲石陶瓷，可以是无孔或多孔形式，其制备方法以及将其作为生物植入材料的方法。
• Catalysts for purifying exhaust and waste gases
  申请人：Nippon Shokubai Kagaku Kogyo Co., Ltd.

  公开号：US04018706A1

  公开（公告）日：1977-04-19

  A catalyst for purifying exhaust and waste gases comprising A. a support substrate comprising 2 to 100% by weight of an oxide complex of titanium and phosphorus containing titanium and phosphrus in such a proportion that the molar ratio of TiO.sub.2 to P.sub.2 O.sub.5 is from 5.0 to 0.5 and 98 to 0% by weight of aluminum oxide, and B. supported on said substrate as a catalytic substance, 2 to 300 parts by weight, calculated as metal oxide per 100 parts by weight of the support substrate (A), of at least one heavy metal selected from the group consisting of Ni, Cu, Cr, Fe, Co, Mn, Bi, V, W, Mo, Sn, Zn, Zr, Pb, Sb, Ti, Ta, Cd and Nb, or 0.01 to 1.0 part by weight, calculated as metal per 100 parts by weight of the support substrate (A), of at least one noble metal selected from the group consisting of Pt, Pd, Rh, Ir, Os and Ru.

  用于净化废气和废气的催化剂，包括A. 支撑基底，其中含有钛和磷的氧化物复合物，其含量为重量的2至100％，钛和磷的摩尔比为TiO.sub.2：P.sub.2 O.sub.5从5.0至0.5，同时含有重量为0至98％的氧化铝；B. 作为催化物质载于所述基底上，重量为100份的支撑基底（A）中计算的金属氧化物2至300份，选自Ni、Cu、Cr、Fe、Co、Mn、Bi、V、W、Mo、Sn、Zn、Zr、Pb、Sb、Ti、Ta、Cd和Nb的至少一种重金属，或重量为100份的支撑基底（A）中计算的金属的0.01至1.0份，选自Pt、Pd、Rh、Ir、Os和Ru的至少一种贵金属。
• Process for producing granular diammonium phosphate
  申请人：Conserv, Inc.

  公开号：US04744965A1

  公开（公告）日：1988-05-17

  A process is disclosed for the manufacture of granular diammonium phosphate (DAP) by reacting anhydrous ammonia with phosphoric acid in a reactor to form reaction product consisting of a partially reacted slurry of monoammonium phosphate and diammonium phosphate. The slurry is pumped to a rotary granulator-reactor where it is further reacted with anhydrous ammonia to form a solid granular diammonium phosphate mixture having a range of particle sizes consisting of undersize, oversize and product. After drying the diammonium phosphate mixture, a portion of the dried granular diammonium phosphate mixture is diverted back to the granulator-reactor prior to delivery to a classifying means. The portion of dried granular diammonium phosphate mixture not diverted to the granulator-reactor, is introduced to a classifying means set to a narrow separation to separate undersize and oversize granular particles from the desired product granular particles. The oversize granular particles are milled and recycled to the granulator-reactor along with the undersize granular particles obtained during the classifying process. The desired granular particles which have a size in the range of 2 mm to 4 mm are collected. About 90% of the granules collected by the classifying means as product are in a range of the desired granule size of 2 mm to 4 mm.

  公开了一种制造颗粒状重铵磷酸二铵（DAP）的工艺，通过在反应器中将无水氨与磷酸反应，形成反应产物，其中包括部分反应的一水磷酸铵和重铵磷酸二铵的混合浆料。将混合浆料泵送到旋转造粒反应器中，其中与无水氨进一步反应，形成具有一定粒度范围的固体颗粒状重铵磷酸二铵混合物，包括细颗粒、粗颗粒和产品。在干燥重铵磷酸二铵混合物后，一部分干燥的颗粒状重铵磷酸二铵混合物被分流回造粒反应器，然后再交付到分类手段。未被分流回造粒反应器的干燥颗粒状重铵磷酸二铵混合物被引入到设定为窄分离的分类手段中，以将细颗粒和粗颗粒与所需产品颗粒分离。粗颗粒被磨碎并回收到造粒反应器中，同时将分类过程中获得的细颗粒与其一起回收。收集尺寸在2毫米至4毫米范围内的所需颗粒。通过分类手段收集的颗粒中，约90％的颗粒尺寸在所需的2毫米至4毫米范围内。