magnesium;sulfate;heptahydrate

• 分子结构分类: 无机化合物 - 混合金属/非金属化合物 - 碱土金属氧阴离子化合物
• 英文名称: magnesium;sulfate;heptahydrate
• 化学式: H14MgO11S
• 分子量: 246.48
• InChiKey: WRUGWIBCXHJTDG-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -7.49
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  95.6
• 氢给体数：
  7
• 氢受体数：
  11

ADMET

毒理性

• 在妊娠和哺乳期间的影响

哺乳期间使用总结：静脉注射镁仅略微增加乳汁中镁的浓度，婴儿对镁的口服吸收不良，因此母亲接受镁治疗预计不会影响哺乳婴儿的血清镁。尽管在分娩前给予的静脉注射硫酸镁可能会影响婴儿的哺乳能力，但哺乳的意愿可能是决定开始哺乳的更重要因素。产后使用静脉注射硫酸镁超过6小时似乎会延迟乳汁的产生。然而，患有更严重的前置胎盘的妇女更有可能接受硫酸镁输注，因此疾病的严重程度也可能在决定哺乳意愿方面发挥作用。 对哺乳婴儿的影响：截至修订日期，未找到相关已发布信息。 对泌乳和母乳的影响：一位因妊娠诱发高血压而接受3天静脉注射硫酸镁的母亲，泌乳II期延迟到产后第10天。尽管没有找到延迟的其他具体原因，但并未进行完整的检查。随后的对照临床试验发现，接受静脉注射硫酸镁治疗的母亲中并未有延迟泌乳的证据。一些（但并非全部）研究发现，由于胎盘将镁传递给胎儿，接受静脉注射硫酸镁的母亲的婴儿在第一次喂养的时间增加或吸吮减少的趋势。另一项研究发现，在接受静脉注射硫酸镁治疗一天以内并打算哺乳的严重前置胎盘妇女中，接受常规新生儿护理的婴儿中有85%，在NICU入院的婴儿中有69%成功开始哺乳。 一项研究随机分配患有前置胎盘的妇女在产后接受6小时或24小时的静脉注射硫酸镁。两组之间子痫的发病率没有差异。然而，接受输注24小时的组乳汁产生延迟，36.5小时与6小时组的25.7小时相比。 在9家拉丁美洲产科医院进行的一项前瞻性、多中心、随机、对照临床试验中，比较了至少接受8克硫酸镁的严重前置胎盘患者与安慰剂组。患者被随机分配继续接受24小时硫酸镁治疗（n = 555）或停止输注（n = 558）。在接受硫酸镁治疗的产后患者中，乳汁产生的时间显著延迟（24.1 vs. 17.1小时）。

◉ Summary of Use during Lactation:Intravenous magnesium increases milk magnesium concentrations only slightly and oral absorption of magnesium by the infant is poor, so maternal magnesium therapy is not expected to affect the breastfed infant's serum magnesium. Although intravenous magnesium sulfate given prior to delivery might affect the infant's ability to breastfeed, intention to breastfeed may be a more important determinant of breastfeeding initiation. Postpartum use of intravenous magnesium sulfate for longer than 6 hours appears to delay the onset of lactation. However, women with more severe pre-eclampsia are more likely to receive magnesium sulfate infusions, so disease severity may also play a part in determining the intention to breastfeed. ◉ Effects in Breastfed Infants:Relevant published information was not found as of the revision date. ◉ Effects on Lactation and Breastmilk:One mother who received intravenous magnesium sulfate for 3 days for pregnancy-induced hypertension had lactogenesis II delayed until day 10 postpartum. No other specific cause was found for the delay, although a complete work-up was not done. A subsequent controlled clinical trial found no evidence of delayed lactation in mothers who received intravenous magnesium sulfate therapy. Some, but not all, studies have found a trend toward increased time to the first feeding or decreased sucking in infants of mothers treated with intravenous magnesium sulfate during labor because of placental transfer of magnesium to the fetus. Another study found that among women with severe pre-eclampsia who received intravenous magnesium sulfate for up to one day postpartum and who intended to breastfeed, 85% of infants receiving routine well-baby care and 69% of those admitted to the NICU, breastfeeding was successfully initiated. A study randomized women with preeclampsia to receive intravenous magnesium sulfate for either 6 or 24 hours postpartum. There was no difference in the rate of eclampsia between the two groups. However, those who received the infusion for 24 hours had a delayed onset of lactation, 36.5 hours compared with 25.7 hours in the 6-hour group. A prospective, multicenter, randomized, controlled trial in 9 Latin American maternity hospitals compared patients with severe pre-eclampsia who had received at least 8 grams of magnesium sulfate prior to placebo. Patients were randomized to continue magnesium sulfate for 24 hours postpartum (n = 555) or stopping the infusion (n = 558). The time to lactation was significantly delayed in those who received magnesium sulfate postpartum (24.1 vs. 17.1 hours).

来源:Drugs and Lactation Database (LactMed)

反应信息

• 作为反应物：
  描述：

  potassium dihydrogenphosphate 、 magnesium;sulfate;heptahydrate 以 水 为溶剂， 生成 Potassium Dihydrogen Phosphate Magnesium Sulfate Heptahydrate
  参考文献：
  名称：

  Process for corn regeneration from tissue culture

  摘要：

  本发明涉及一种玉米组织培养再生的方法，包括以下步骤：(a)在含有激素吡克拉姆、矿物质盐、维生素和蔗糖的愈伤组织诱导培养基上培养玉米组织，产生胚性愈伤组织；(b)将胚性愈伤组织在含有激素吡克拉姆、矿物质盐、维生素和蔗糖的愈伤组织维持培养基上继续培养；(c)将胚性愈伤组织在含有矿物质盐、维生素和蔗糖的再生培养基上培养，产生植株；(d)将植株在含有矿物质盐、维生素和蔗糖的成熟培养基上继续培养，促进根和茎的发育。

  公开号：

  USH0000951H1
• 作为产物：
  描述：

  magnesium sulfate 以 水 为溶剂， 以to form magnesium sulfate heptahydrate, or only 1.05 kg water/kg magnesium sulfate的产率得到magnesium;sulfate;heptahydrate
  参考文献：
  名称：

  Solid microbicidal composition

  摘要：

  一种固体杀菌组合物，包含5-氯-2-甲基-4-异噻唑啉-3-酮和2-甲基-4-异噻唑啉-3-酮的混合物，硫酸镁，金属硝酸盐，氯化镁和水。

  公开号：

  US08197836B2
• 作为试剂：
  描述：

  葡萄糖 、 5-(1-hydroxyethyl) furo[2,3-c]pyridine 在 Azanium;azane;dihydrogen phosphate 、 potassium dihydrogenphosphate 、 magnesium;sulfate;heptahydrate 、 Zinc Sulfate Heptahydrate 、 (hexaaqua)iron(II) sulfate monohydrate 、 Copper sulfate pentahydrate 、 四水硫酸锰 、 氯化钠 、 葡萄糖 、 1-(呋喃并[2,3-c]吡啶-5-基)乙酮 作用下， 反应 98.33h， 生成 1-(呋喃并[2,3-c]吡啶-5-基)乙酮
  参考文献：
  名称：

  Enzyme for producing optically active pyridineethanol derivatives

  摘要：

  本发明涉及一种制备光学活性吡啶乙醇衍生物的方法。更具体地说，它涉及一种通过使酶或酶源作用于多环乙酰吡啶衍生物而制备光学活性多环吡啶乙醇衍生物的方法。本发明还涉及一种新的酶，可用于上述生产方法，编码该酶的DNA，具有该DNA的重组载体，以及具有该重组载体的转化体。本发明还涉及一种通过使上述新酶或上述转化体作用于光学不活性多环吡啶乙醇衍生物而制备光学活性多环吡啶乙醇衍生物的方法。

  公开号：

  US07329518B2

文献信息

• Method for producing L-aspartic acid
  申请人：Tanabe Seiyaku Co., Ltd.

  公开号：US04656136A1

  公开（公告）日：1987-04-07

  A novel microorganism of the genus Serratia containing a hybrid plasmid prepared by integrating a plasmid with a deoxyribonucleic acid carrying the gene for aspartase which is obtained from a microorganism of the genus Serratia. An industrially advantageous method for producing L-aspartic acid comprising contacting a culture of the novel microorganism, microbial cells collected from the culture or a processed material of the microbial cells with fumaric acid and ammonia to produce L-aspartic acid and then collecting L-aspartic acid thus produced is also disclosed.

  本发明涉及一种杆菌属的新型微生物，其中包含一种杂交质粒，该质粒通过将携带天冬氨酸酶基因的脱氧核糖核酸与杆菌属的微生物获得。本发明还涉及一种工业上有利的生产L-天冬氨酸的方法，包括将新型微生物的培养物、从培养物中收集的微生物细胞或经过处理的微生物细胞的材料与富马酸和氨接触以产生L-天冬氨酸，然后收集产生的L-天冬氨酸。
• Method for concurrent fermentation of basic amino acid and acidic amino
  申请人：Ajinomoto Co., Inc.

  公开号：US05196326A1

  公开（公告）日：1993-03-23

  A basic L-amino acid and an acidic L-amino acid may be concurrently produced by either culturing a basic L-amino acid-producing bacteria under conditions for producing an acidic L-amino acid or mix-culturing a basic L-amino acid-producing bacteria and an acidic L-amino acid-producing bacteria.

  一种基础性L-氨基酸和一种酸性L-氨基酸可以同时由以下两种方式之一产生：将一种产生基础性L-氨基酸的细菌培养在产生酸性L-氨基酸的条件下，或将产生基础性L-氨基酸的细菌和产生酸性L-氨基酸的细菌混合培养。
• Mutated isopropylmalate isomerase
  申请人：Ikeda Masato

  公开号：US20050130276A1

  公开（公告）日：2005-06-16

  The present invention provides a polypeptide comprising an amino acid sequence in which at least one amino acid is deleted, substituted or added in an amino acid sequence of isopropylmalate isomerase derived from a microorganism belonging to coryneform bacteria, wherein a coryneform bacterium which produces the polypeptide comprising the amino acid sequence as the sole isopropylmalate isomerase exhibits a partial leucine requirement in a minimal medium; a DNA encoding the polypeptide, a recombinant DNA comprising the DNA, a microorganism transformed with the recombinant DNA, and a process for producing an L-amino acid using the microorganism.

  本发明提供了一个多肽，其包括从属于Coryneform细菌的微生物中获得的异丙基丙酸异构酶的氨基酸序列中至少删除，替换或添加了至少一个氨基酸，其中生产包含该氨基酸序列作为唯一异丙基丙酸异构酶的Coryneform细菌在最小培养基中表现出部分亮氨酸需求；编码该多肽的DNA，包含该DNA的重组DNA，转化了重组DNA的微生物以及使用该微生物生产L-氨基酸的方法。
• Process for making amine molybdates
  申请人：The B. F. Goodrich Company

  公开号：US04217292A1

  公开（公告）日：1980-08-12

  Amine molybdates are formed by reacting molybdenum trioxide (MoO.sub.3) with an amine in an aqueous medium essentially free of acid and in which is dissolved a water-soluble ammonium or monovalent metal or divalent metal or trivalent rare earth metal salt of an acid, or a combination thereof. Although the reaction may be carried out at room temperature, the reaction mixture desirably is heated to between about 75.degree. C. to 110.degree. C. and preferably is refluxed to reduce the time required for completion of the reaction. The reaction slurry is stirred while the reaction is occurring. Upon completion of the reaction, the amine molybdate is separated from the liquid phase, and is washed and dried. After removal of the solid amine molybdate from the slurry the liquid component can be reused avoiding possible environmental difficulties.

  胺钼酸盐是通过在基本无酸的水溶介质中，将三氧化钼（MoO.sub.3）与胺反应，并在其中溶解一种酸的水溶性铵盐、一价金属盐、二价金属盐或三价稀土金属盐，或它们的组合物形成的。虽然反应可以在室温下进行，但反应混合物最好加热至约75℃到110℃之间，并最好回流以缩短反应所需的时间。在反应发生时，搅拌反应浆。反应完成后，将胺钼酸盐从液相中分离出来，并进行洗涤和干燥。在从浆液中除去固体胺钼酸盐后，液体组分可以被重复使用，避免可能的环境问题。
• Process for producing ammonia and sulfur dioxide
  申请人：Kuraray Co., Ltd.

  公开号：US04990319A1

  公开（公告）日：1991-02-05

  A process for producing NH.sub.3 and SO.sub.2 from ammonium sulfate, which comprises (i) reacting ammonium sulfate with a metal oxide or hydroxide at a temperature of not more than 200.degree. C. to form NH.sub.3, water and a metal sulfate and recovering NH.sub.3, (ii) decomposing the metal sulfate in the presence of a reducing agent to form a metal oxide and SO.sub.2 and recovering SO.sub.2, and (iii) recycling the metal oxide to step (i) as such or after it is converted to a metal hydroxide.

  从硫酸铵生产NH.sub.3和SO.sub.2的过程，包括(i)在不超过200℃的温度下，将硫酸铵与金属氧化物或氢氧化物反应，形成NH.sub.3，水和金属硫酸盐，并回收NH.sub.3，(ii)在还原剂的存在下分解金属硫酸盐，形成金属氧化物和SO.sub.2，并回收SO.sub.2，以及(iii)将金属氧化物回收到步骤(i)中，作为金属氢氧化物或直接使用。

表征谱图