3,5-二(丙酰基氨基)-2,4,6-三碘苯甲酸 | 85-16-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 3,5-二(丙酰基氨基)-2,4,6-三碘苯甲酸
• 英文名称: 2.4.6-Triiod-3.5-bis-propionylamino-benzoesaeure
• 英文别名: Diprotizoic acid；2,4,6-triiodo-3,5-bis-propionylamino-benzoic acid；2,4,6-Trijod-3,5-bis-propionylamino-benzoesaeure；Diprotrizoic acid；2,4,6-triiodo-3,5-bis(propanoylamino)benzoic acid
• CAS: 85-16-5
• 化学式: C₁₃H₁₃I₃N₂O₄
• 分子量: 641.971
• InChiKey: OIXRDAZPDINJPT-UHFFFAOYSA-N

物化性质

• 熔点：
  >340 °C
• 沸点：
  623.4±55.0 °C(Predicted)
• 密度：
  2.401±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  95.5
• 氢给体数：
  3
• 氢受体数：
  4

安全信息

• 海关编码：
  2924299090

反应信息

• 作为产物：
  描述：

  3,5-二氨基-2,4,6-三碘苯甲酸 在 氢氧化钾 作用下， 生成 3,5-二(丙酰基氨基)-2,4,6-三碘苯甲酸
  参考文献：
  名称：

  DE970133

  摘要：

  公开号：

文献信息

• METHODS OF SYNTHESIS AND USE OF CHEMOSPHERES
  申请人：Barnett Bradley Powers

  公开号：US20110104052A1

  公开（公告）日：2011-05-05

  The present invention provides, in general, compositions comprising a hydrogel and an agent, for example a therapeutic agent or an imaging agent, for locoregional delivery. In certain preferred embodiments of the invention, the hydrogel compositions are detectable by Magnetic Responance and CT Scan and are used for locoregional delivery of therapeutic agents, for example chemotherapeutic agents. The invention also features polymer matrix compositions comprising nanoparticles that can be loaded after polymerization with bioactive agents, for example a diagnostic agent or therapeutic agent.

  本发明提供了一般的组合物，包括水凝胶和药剂，例如治疗剂或成像剂，用于局部区域输送。在本发明的某些优选实施例中，水凝胶组合物可以通过磁共振和CT扫描检测，并用于局部区域输送治疗剂，例如化疗剂。本发明还涉及聚合物基质组合物，包括纳米颗粒，可以在聚合后装载生物活性剂，例如诊断剂或治疗剂。
• Novel targeted compositions for diagnostic and therapeutic use
  申请人：——

  公开号：US20020159951A1

  公开（公告）日：2002-10-31

  Novel targeted compositions which may be used for diagnostic and therapeutic use. The compositions may comprise lipid, protein or polymer gas-filled vesicles which further comprise novel compounds of the general formula L-P-T, wherein L comprises a hydrophobic compound, P comprises a hydrophilic polymer, and T comprises a targeting ligand which targets tissues, cells or receptors, including myocardial cells, endothelial cells, epithelial cells, tumor cells and the glycoprotein GPIIbIIIa receptor. The compositions can be used in conjunction with diagnostic imaging, such as ultrasound, as well as therapeutic applications, such as therapeutic ultrasound.

  这是一种可用于诊断和治疗的新型靶向组合物。该组合物可能包含脂质、蛋白质或聚合物气体充填的囊泡，进一步包括一般式为L-P-T的新化合物，其中L包括疏水化合物，P包括亲水性聚合物，T包括靶向配体，可靶向组织、细胞或受体，包括心肌细胞、内皮细胞、上皮细胞、肿瘤细胞和糖蛋白GPIIbIIIa受体。该组合物可与诊断成像技术（如超声）以及治疗应用（如治疗性超声）结合使用。
• Method of preparing liposomes and products produced thereby
  申请人：E.R. Squibb & Sons, Inc.

  公开号：EP0119020A2

  公开（公告）日：1984-09-19

  A method is provided for preparing a stable liposome precursors in the form of a particulate carrier materials coated with thin films of liposome components, which method includes the steps of dissolving at least one liposome-forming amphipathic lipid, optionally, at least one biologically active compound, and, optionally, at least one adjuvant in a suitable solvent and employing the resulting solution to coat a suitable particulate carrier material which is substantially insoluble in the above-mentioned solvent, to form thin films of liposome components thereon. Upon exposing the coated carrier material to water, the thin films of liposome components hydrate. If the carrier material is water-insoluble, it is then separated e.g. by filtration or centrifuging.

  本发明提供了一种制备稳定的脂质体前体的方法，其形式为涂有脂质体成分薄膜的微粒载体材料，该方法包括以下步骤：将至少一种脂质体形成两性脂质、可选的至少一种生物活性化合物和可选的至少一种佐剂溶解在一种合适的溶剂中，并用所得溶液涂覆在基本上不溶于上述溶剂的合适的微粒载体材料上，以在其上形成脂质体成分薄膜。将涂覆的载体材料置于水中，脂质体成分薄膜就会水合。如果载体材料不溶于水，则通过过滤或离心等方法将其分离。
• Contrast media
  申请人：NYCOMED IMAGING AS

  公开号：EP0414288A1

  公开（公告）日：1991-02-27

  There is provided a contrast medium comprising a physiologically tolerable paramagnetic metal species containing substance together with a water soluble iodinated X-ray contrast agent.

  本文提供了一种造影剂，它由一种生理上可耐受的顺磁性金属物质和一种水溶性碘化 X 射线造影剂组成。
• Particulate contrast media
  申请人：NYCOMED IMAGING AS

  公开号：EP0414287A1

  公开（公告）日：1991-02-27

  There is provided a magnetic resonance contrast medium comprising magnetically responsive particles and a physiologically tolerable osmoactive agent.

  提供了一种磁共振造影剂，它由磁响应颗粒和生理上可耐受的渗透剂组成。