4-methoxy-3-(tolyloxy)benzaldehyde | 93899-03-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-methoxy-3-(tolyloxy)benzaldehyde
• 英文别名: 5-Formyl-2-methoxy-4'-methyl-diphenyl-aether；4-Methoxy-3-(4-methylphenoxy)benzaldehyde
• CAS: 93899-03-7
• 化学式: C₁₅H₁₄O₃
• 分子量: 242.274
• InChiKey: VDGOULOFGOYYES-UHFFFAOYSA-N

物化性质

• 沸点：
  391.5±27.0 °C(Predicted)
• 密度：
  1.142±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3,4-二羟基苯甲醛 在 sodium hydride 、 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 49.0h， 生成 4-methoxy-3-(tolyloxy)benzaldehyde
  参考文献：
  名称：

  Studies on the synthesis of aryl ethers using arene-manganese chemistry

  摘要：

  Selective arylation of polyfunctional phenols, using chlorobenzene- and p-chlorotoluene-manganese tricarbonyl cations, is described. The intermediate arene-manganese complexes are found to undergo stereo- and regioselective reactions with Schollkopf's chiral glycine enolate equivalent to give dienyl-Mn(CO)3 complexes. Treatment of these complexes with N-bromosuccinimide at room temperature, followed by hydrolysis of the dihydropyrazine, gives diaryl ethers in which one of the aromatic rings is an arylglycine methyl ester.

  DOI：

  10.1021/jo00025a026

文献信息

• 870. Bisbenzylisoquinolines. Part IV. The preparation of diaryl ethers from diaryliodonium salts
  作者：J. R. Crowder、E. E. Glover、M. F. Grundon、H. X. Kaempfen

  DOI：10.1039/jr9630004578

  日期：——
• Studies on the synthesis of aryl ethers using arene-manganese chemistry
  作者：Anthony J. Pearson、Paul R. Bruhn

  DOI：10.1021/jo00025a026

  日期：1991.12

  Selective arylation of polyfunctional phenols, using chlorobenzene- and p-chlorotoluene-manganese tricarbonyl cations, is described. The intermediate arene-manganese complexes are found to undergo stereo- and regioselective reactions with Schollkopf's chiral glycine enolate equivalent to give dienyl-Mn(CO)3 complexes. Treatment of these complexes with N-bromosuccinimide at room temperature, followed by hydrolysis of the dihydropyrazine, gives diaryl ethers in which one of the aromatic rings is an arylglycine methyl ester.