N-ethyl-4-(N-[4-vinylphenyl]hydrazinecarboxamidyl)-1,8-naphthalimide | 1357009-31-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: N-ethyl-4-(N-[4-vinylphenyl]hydrazinecarboxamidyl)-1,8-naphthalimide
• 英文别名: 1-(4-Ethenylphenyl)-3-[(2-ethyl-1,3-dioxobenzo[de]isoquinolin-6-yl)amino]urea；1-(4-ethenylphenyl)-3-[(2-ethyl-1,3-dioxobenzo[de]isoquinolin-6-yl)amino]urea
• CAS: 1357009-31-4
• 化学式: C₂₃H₂₀N₄O₃
• 分子量: 400.437
• InChiKey: XPJKIIMXIAKKRY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  30
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  90.5
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  6-bromo-2-ethyl-1H-benzo[de]isoquinoline-1,3(2H)dione 在 吡啶 、 一水合肼 作用下， 以 四氢呋喃 、 1,4-二氧六环 为溶剂， 反应 66.0h， 生成 N-ethyl-4-(N-[4-vinylphenyl]hydrazinecarboxamidyl)-1,8-naphthalimide
  参考文献：
  名称：

  Synthesis, Spectroscopic, and Analyte-Responsive Behavior of a Polymerizable Naphthalimide-Based Carboxylate Probe and Molecularly Imprinted Polymers Prepared Thereof

  摘要：

  A naphthalimide-based fluorescent indicator monomer 1 for the integration into chromo- and fluorogenic molecularly imprinted polymers (MIPs) was synthesized and characterized. The monomer was equipped with a urea binding site to respond to carboxylate-containing guests with absorption and fluorescence changes, namely a bathochromic shift in absorption and fluorescence quenching. Detailed spectroscopic analyses of the title compound and various models revealed the signaling mechanism. Titration studies employing benzoate and Z-L-phenylalanine (Z-L-Phe) suggest that indicator monomers such as the title compound undergo a mixture of deprotonation and complex formation in the presence of benzoate but yield hydrogen-bonded complexes, which are desirable for the molecular imprinting process, with weakly basic guests like Z-L-Phe. Compound 1 could be successfully employed in the synthesis of monolithic and thin-film MIPs against Z-L-Phe, Z-L-glutamic acid, and penicillin G. Chromatographic assessment of the selectivity features of the monoliths revealed enantioselective discrimination and clear imprinting effects. Immobilized on glass coverslips, the thin-film MIPs of 1 displayed a clear signaling behavior with a pronounced enantioselective fluorescence quenching dependence and a promising discrimination against cross-analytes.

  DOI：

  10.1021/jo3019522

文献信息

• Molecularly imprinted polymers
  申请人：Shinde Sudhirkumar

  公开号：US10730986B2

  公开（公告）日：2020-08-04

  The present invention relates to a molecularly imprinted polymer for binding glycans, wherein the molecularly imprinted polymer is obtainable by providing a saccharide template such as a glycan; providing at least two functional monomers capable of cooperatively; interacting with the template; providing a crosslinking monomer; polymerizing the monomers optionally dissolved in a solvent, in presence of the saccharide template; and removing the template from the formed polymer. The invention is also related to a method for their production and use of the molecularly imprinted polymer.

  本发明涉及一种用于结合聚糖的分子印迹聚合物，其中该分子印迹聚合物可通过以下方式获得：提供糖类模板（如聚糖）；提供至少两种能够与模板协同作用的功能性单体；提供交联单体；在糖类模板存在的情况下，使溶解在溶剂中的单体聚合；以及从形成的聚合物中去除模板。本发明还涉及分子印迹聚合物的生产和使用方法。
• Surface plasmon resonance sensor comprising metal coated nanostructures and a molecularly imprinted polymer layer
  申请人：DrinkSavvy, Inc.

  公开号：US11280723B2

  公开（公告）日：2022-03-22

  A colorimetric sensor for detecting an analyte of interest that includes a metal layer disposed upon a substrate, a plurality of nanostructures, and a corresponding plurality of metal deposits spaced apart from the metal layer. The metal layer defines a plurality of holes, each nanostructure includes a first portion disposed within a respective hole, and each metal deposit is disposed upon a second portion of a respective nanostructure. The sensor also includes a molecularly imprinted polymer layer that may cover the metal layer, the nanostructures, and/or the metal deposits. The molecularly imprinted polymer layer defines a cavity shaped to receive the analyte of interest, and the sensor is configured such that, when an analyte contacts the molecularly imprinted polymer layer and becomes disposed within the cavity, an optical property of at least a portion of the sensor changes thereby to cause a detectable color change in and/or from the sensor.

  一种用于检测相关分析物的比色传感器，包括设置在基底上的金属层、多个纳米结构以及与金属层间隔开的相应的多个金属沉积物。金属层定义了多个孔，每个纳米结构包括设置在相应孔内的第一部分，每个金属沉积物设置在相应纳米结构的第二部分上。传感器还包括可覆盖金属层、纳米结构和/或金属沉积物的分子印迹聚合物层。分子印迹聚合物层限定了一个空腔，该空腔的形状是用来接收感兴趣的分析物，传感器被配置成当分析物接触分子印迹聚合物层并进入空腔时，传感器至少一部分的光学特性会发生变化，从而导致传感器内和/或从传感器中产生可检测的颜色变化。
• POLYMERIC COMPLEMENTS TO A B-AMYLOID PEPTIDES
  申请人：Sellergren Boerje

  公开号：US20130171066A1

  公开（公告）日：2013-07-04

  The present invention relates to the preparation and use of polymer complements to β-amyloid peptides (Aβ) for detecting soluble or aggregated Aβ in fluid samples or for treating a subject having a neurodegenerative disease.
• COLORIMETRIC CHEMICAL SENSOR WITH ENHANCED COLOR SENSITIVITY
  申请人：DrinkSavvy, Inc.

  公开号：US20190265169A1

  公开（公告）日：2019-08-29

  A colorimetric sensor for detecting an analyte of interest in a fluid sample includes a lamellar photonic material having alternating layers of a first polymer layer and a second polymer layer. Each first polymer layer can be a molecularly imprinted polymer defining a cavity shaped to receive an analyte of interest. The photonic material is configured such that, when an analyte contacts the photonic material and becomes disposed within a cavity of the molecularly imprinted polymer, a refractive property of the photonic material changes, causing a detectable color change in the sensor.
• SURFACE PLASMON RESONANCE SENSOR COMPRISING METAL COATED NANOSTRUCTURES AND A MOLECULARLY IMPRINTED POLYMER LAYER
  申请人：DrinkSavvy, Inc.

  公开号：US20190317011A1

  公开（公告）日：2019-10-17

  A colorimetric sensor for detecting an analyte of interest that includes a metal layer disposed upon a substrate, a plurality of nanostructures, and a corresponding plurality of metal deposits spaced apart from the metal layer. The metal layer defines a plurality of holes, each nanostructure includes a first portion disposed within a respective hole, and each metal deposit is disposed upon a second portion of a respective nanostructure. The sensor also includes a molecularly imprinted polymer layer that may cover the metal layer, the nanostructures, and/or the metal deposits. The molecularly imprinted polymer layer defines a cavity shaped to receive the analyte of interest, and the sensor is configured such that, when an analyte contacts the molecularly imprinted polymer layer and becomes disposed within the cavity, an optical property of at least a portion of the sensor changes thereby to cause a detectable color change in and/or from the sensor.