2-methyltetrahydropyran-3-ol | 72075-81-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧烷类
• 英文名称: 2-methyltetrahydropyran-3-ol
• 英文别名: (2S,3R)-2-methyloxan-3-ol
• CAS: 72075-81-1
• 化学式: C₆H₁₂O₂
• 分子量: 116.16
• InChiKey: SKRABBMADUGSQM-NTSWFWBYSA-N

物化性质

• 沸点：
  197.0±8.0 °C(Predicted)
• 密度：
  1.014±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4,5-epoxyhexanol 在 caesium carbonate 作用下， 以 甲醇 为溶剂， 反应 20.0h， 生成 2-methyltetrahydropyran-3-ol 、 1-(四氢呋喃-2-基)乙醇
  参考文献：
  名称：

  Ladder Polyether Synthesis via Epoxide-Opening Cascades Directed by a Disappearing Trimethylsilyl Group

  摘要：

  Epoxide-opening cascades offer the potential to construct complex polyether natural products expeditiously and in a manner that emulates the biogenesis proposed for these compounds. Herein we provide a full account of our development of a strategy that addresses several important challenges of such cascades. The centerpiece of the method is a trimethylsilyl (SiMe3) group that serves several purposes and leaves no trace of itself by the time the cascade has come to an end. The main function of the SiMe3 group is to dictate the regioselectivity of epoxide opening. This strategy is the only general method of effecting endo-selective cascades under basic conditions.

  DOI：

  10.1021/jo1002455

文献信息

• SPECIFICALLY ACTIVATED MICROMOLECULAR TARGET COUPLING BODY IN TUMOR MICROENVIRONMENT AND USE THEREOF
  申请人：Yafei Shanghai Biolog Medicine Science& Technology

  公开号：EP3184540A1

  公开（公告）日：2017-06-28

  Provided are an anticancer compound comprising a cleavable linker specifically activated in a tumor microenvironment, and use thereof. The anticancer compound is represented by the following formula, wherein, R1 is a normal functional group or a protection group; R2 is Ala, Thr, Val or Ile; R3 is Ala, Val or Asn; R4 is a drug group linked via a hydroxyl group or an amino group; and the general formula of the drug is R4H. The anticancer compound is only activated at a local portion of a tumor, thus avoiding the defect of immune system damage of a traditional chemotherapeutic drug, and promoting tumor immunization by removing a tumor immunosuppression cell. The anticancer compound or pharmaceutical composition thereof is jointly used with immunotherapy, thus improving the effect of treating the tumor, and effectively inhibiting tumor metastasis and osseous metastasis.

  本发明提供了一种抗癌化合物及其用途，该化合物包含在肿瘤微环境中特异性激活的可裂解连接体。该抗癌化合物由下式表示，其中，R1为正常官能团或保护基；R2为Ala、Thr、Val或Ile；R3为Ala、Val或Asn；R4为通过羟基或氨基连接的药物基团；药物通式为R4H。该抗癌化合物仅在肿瘤局部被激活，从而避免了传统化疗药物对免疫系统损伤的缺陷，并通过清除肿瘤免疫抑制细胞促进肿瘤免疫。该抗癌化合物或其药物组合物与免疫疗法联合使用，可提高治疗肿瘤的效果，有效抑制肿瘤转移和骨转移。
• Tomatidine, analogs thereof, compositions comprising same, and uses for same
  申请人：UNIVERSITY OF IOWA RESEARCH FOUNDATION

  公开号：US10576091B2

  公开（公告）日：2020-03-03

  In one aspect, the invention relates to methods for promoting muscle hypertrophy or decreasing adiposity by providing to an animal in need thereof an effective amount of a compound. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

  一方面，本发明涉及通过向有需要的动物提供有效量的化合物来促进肌肉肥大或减少脂肪的方法。本摘要旨在作为一种扫描工具，用于在特定技术领域进行搜索，而无意限制本发明。
• Hot Water-Promoted Ring-Opening of Epoxides and Aziridines by Water and Other Nucleopliles
  作者：Zhi Wang、Yong-Tao Cui、Zhao-Bing Xu、Jin Qu

  DOI：10.1021/jo702401t

  日期：2008.3.1

  Effective hydrolysis of epoxides and aziridines was conducted by heating them in water at 60 or 100 degrees C. Other types of nucleophile such as amines, sodium azide, and thiophenol could also efficiently open epoxides and aziridines in hot water. It was proposed that hot water acted as a modest acid catalyst, reactant, and solvent in the hydrolysis reactions.
• Steric course of the reductions of 2-alkyltetrahydropyranones
  作者：Giorgio Catelani、Luigi Monti、Mariangela Ugazio

  DOI：10.1021/jo01293a031

  日期：1980.2