methyl 2-(4-fluorophenyl)-2-chloroacetate | 1036273-29-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: methyl 2-(4-fluorophenyl)-2-chloroacetate
• 英文别名: Methyl 2-chloro-2-(4-fluorophenyl)acetate
• CAS: 1036273-29-6
• 化学式: C₉H₈ClFO₂
• mdl: MFCD16694233
• 分子量: 202.613
• InChiKey: FTLXTMDPQAOBNK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.222
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  methyl 2-(4-fluorophenyl)-2-chloroacetate 在 甲醇 、 sodium dithionite 作用下， 以60%的产率得到4-氟苯基乙酸甲酯
  参考文献：
  名称：

  WO2008/78350

  摘要：

  公开号：
• 作为产物：
  描述：

  2-(4-氟苯基)-2-羟基乙酸甲酯 在 4-二甲氨基吡啶 、 氯化亚砜 作用下， 反应 1.0h， 以68%的产率得到methyl 2-(4-fluorophenyl)-2-chloroacetate
  参考文献：
  名称：

  WO2008/78350

  摘要：

  公开号：

文献信息

• MULTI-CYCLIC COMPOUNDS
  申请人：KIMURA Teiji

  公开号：US20090062529A1

  公开（公告）日：2009-03-05

  A compound represented by the formula (I): or a pharmacologically acceptable salt thereof, wherein Ar 1 represents an imidazolyl group or the like which may be substituted with a C1-6 alkyl group, Ar 2 represents a phenyl group or the like which may be substituted with a C1-6 alkoxy group, X 1 represents a double bond or the like and Het represents a triazolyl group or the like which may be substituted with a C1-6 alkyl group or the like, is effective as a therapeutic or prophylactic agent for a disease caused by Aβ.

  一种由化学式(I)表示的化合物或其药理学可接受的盐，其中Ar1代表可用C1-6烷基基团取代的咪唑基团或类似基团，Ar2代表可用C1-6烷氧基团取代的苯基团或类似基团，X1代表双键或类似基团，Het代表可用C1-6烷基基团或类似基团取代的三唑基团或类似基团，对由Aβ引起的疾病具有治疗或预防作用。
• [EN] MINERALOCORTICOID RECEPTOR ANTAGONISTS<br/>[FR] ANTAGONISTES DU RÉCEPTEUR DES MINÉRALOCORTICOÏDES
  申请人：MERCK SHARP & DOHME

  公开号：WO2012097744A1

  公开（公告）日：2012-07-26

  Disclosed are the compounds of the Formula (I) as well as pharmaceutically acceptable salts thereof, which are useful for treating aldosterone-mediated diseases. The processes for preparing compounds of the Formula (I), the use for the therapy and prophylaxis of the abovementioned diseases and for preparing pharmaceuticals for this purpose, and the pharmaceutical compositions which comprise compounds of the formula (I) are disclosed too.

  本公开了公式（I）的化合物以及其药学上可接受的盐，这些化合物对于治疗醛固酮介导的疾病是有用的。还公开了制备公式（I）化合物的方法，用于治疗和预防上述疾病以及为此目的制备药物的用途，以及包括公式（I）化合物的药物组合物。
• IMIDAZOYL PYRIDINE COMPOUNDS AND SALTS THEREOF
  申请人：KIMURA Teiji

  公开号：US20110065696A1

  公开（公告）日：2011-03-17

  A compound represented by the formula (I): or a pharmacologically acceptable salt thereof, wherein Ar 1 represents an imidazolyl group or the like which may be substituted with a C1-6 alkyl group, Ar 2 represents a phenyl group or the like which may be substituted with a C1-6 alkoxy group, X 1 represents a double bond or the like and Het represents a triazolyl group or the like which may be substituted with a C1-6 alkyl group or the like, is effective as a therapeutic or prophylactic agent for a disease caused by Aβ.

  化合物的化学式为(I)或其药理学上可接受的盐，其中Ar1代表咪唑基团或类似基团，该基团可能被C1-6烷基取代，Ar2代表苯基或类似基团，该基团可能被C1-6烷氧基取代，X1代表双键或类似基团，Het代表三唑基团或类似基团，该基团可能被C1-6烷基或类似基团取代，可用作治疗或预防由Aβ引起的疾病的药物。
• MINERALOCORTICOID RECEPTOR ANTAGONISTS
  申请人：Crespo Alejandro

  公开号：US20130331419A1

  公开（公告）日：2013-12-12

  Disclosed are the compounds of the Formula (I) as well as pharmaceutically acceptable salts thereof, which are useful for treating aldosterone-mediated diseases. The processes for preparing compounds of the Formula (I), the use for the therapy and prophylaxis of the abovementioned diseases and for preparing pharmaceuticals for this purpose, and the pharmaceutical compositions which comprise compounds of the formula (I) are disclosed too.

  本发明涉及公式（I）的化合物及其药学上可接受的盐，用于治疗醛固酮介导的疾病。还揭示了制备公式（I）化合物的方法，用于治疗和预防上述疾病以及制备药物的用途，以及包含公式（I）化合物的制药组合物。
• POLYCYCLIC COMPOUND
  申请人：Kimura Teiji

  公开号：US20110009619A1

  公开（公告）日：2011-01-13

  Disclosed is a compound represented by the formula (I): or a pharmacologically acceptable salt thereof, which is effective as a therapeutic or prophylactic agent for a disease induced by Aβ, wherein Ar 1 represents an imidazolyl group which may be substituted with a C1-6 alkyl group, or the like; Ar 2 represents a phenyl group which may be substituted with a C1-6 alkoxy group, or the like; X 1 represents a double bond, or the like; and Het represents a triazolyl group or the like which may be substituted with a C1-6 alkyl group or the like, or the like.

  本发明涉及一种化合物，其化学式为(I)：或其药学上可接受的盐，该化合物有效地作为由Aβ引起的疾病的治疗或预防剂。其中，Ar1表示咪唑基，可以用C1-6烷基等取代；Ar2表示苯基，可以用C1-6烷氧基等取代；X1表示双键等；Het表示三唑基等，可以用C1-6烷基等取代。