3-formyl-N,N,N-trimethylanilinium iodide | 63982-01-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-formyl-N,N,N-trimethylanilinium iodide
• 英文别名: 3-formyl-N,N,N-trimethyl-benzenaminium iodide；3-formyl-tri-N-methyl-anilinium; iodide；3-Formyl-tri-N-methyl-anilinium; Jodid；3-Formylphenyltrimethylammonium iodide；(3-formylphenyl)-trimethylazanium;iodide
• CAS: 63982-01-4
• 化学式: C₁₀H₁₄NO*I
• 分子量: 291.132
• InChiKey: AQAFGBBLBXMGNS-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -1.3
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-formyl-N,N,N-trimethylanilinium iodide 200.0 ℃ 、2.0 kPa 条件下， 生成 3-二甲基氨基苯甲醛
  参考文献：
  名称：

  399.制备米-dimethylaminobenzaldehyde。第一部分

  摘要：

  DOI：

  10.1039/jr9370001891
• 作为产物：
  描述：

  3-aminobenzaldehyde diethyl acetal 、 碘甲烷 在 sodium carbonate 作用下， 生成 3-formyl-N,N,N-trimethylanilinium iodide
  参考文献：
  名称：

  399.制备米-dimethylaminobenzaldehyde。第一部分

  摘要：

  DOI：

  10.1039/jr9370001891

文献信息

• Neither azeotropic drying, nor base nor other additives: a minimalist approach to ¹⁸F-labeling
  作者：R. Richarz、P. Krapf、F. Zarrad、E. A. Urusova、B. Neumaier、B. D. Zlatopolskiy

  DOI：10.1039/c4ob01336k

  日期：——

  A novel, efficient, time-saving and reliable radiolabeling procedure via nucleophilic substitution with [18F]fluoride is described. Different radiolabeled aliphatic and aromatic compounds were prepared in high radiochemical yields simply by heating of quaternary anilinium, diaryliodonium and triarylsulfonium [18F]fluorides in suitable solvents. The latter were obtained via direct elution of 18F− from

  描述了一种通过[ 18 F]氟化物进行亲核取代的新颖，高效，省时且可靠的放射性标记程序。只需在合适的溶剂中加热季铵，二芳基碘鎓和三芳基ulf [ 18 F]氟化物，即可以高放射化学收率制备不同的放射性标记的脂族和芳族化合物。后者，获得经由直接洗脱18 ˚F -由阴离子交换树脂与鎓前体的醇溶液制得。不需要共沸蒸发水，也不需要碱，也不需要任何其他添加剂，例如穴状配体或冠醚。由于其简单性，该方法应非常适合于自动放射合成，尤其是在微流体装置中。
• Preparation of quarternary ammonium salt-tagged ferrocenylphosphine-imine ligands and their application to palladium-catalyzed asymmetric allylic substitution
  作者：Hao Yuan、Zhiming Zhou、Jiangliang Xiao、Lixuan Liang、Li Dai

  DOI：10.1016/j.tetasy.2010.05.047

  日期：2010.8

  A series of novel quarternary ammonium salt-modified chiral ferrocenylphosphine-imine ligands have been synthesized and the molecular structure of BIT5 has been determined by single-crystal X-ray diffraction. The applicability of these ligands in asymmetric C*-C and C*-N bond formation was demonstrated. High enantioselectivity was obtained in the Pd-catalyzed asymmetric substitution of 1,3-diphenyl-2-propenyl acetate, with dimethyl malonate (up to 94.6% ee) and benzylamine (up to 92.6% ee). (C) 2010 Published by Elsevier Ltd.
• 88. Symmetrical triad prototropic systems. Part VIII. The analogy between symmetrical triad systems and aromatic side-chain reactivity, and the effect of m-substitution on mobility and equilibrium in the αγ-diphenylmethyleneazomethine system
  作者：Charles William Shoppee

  DOI：10.1039/jr9320000696

  日期：——
• 1,4-Dihydropyridine antagonist activities at the calcium channel: a quantitative structure-activity relationship approach
  作者：Robert A. Coburn、Mark Wierzba、Mark J. Suto、Alan J. Solo、A. M. Triggle、David J. Triggle

  DOI：10.1021/jm00119a009

  日期：1988.11

  The effect of 46 1,4-dihydropyridine-type calcium channel antagonists on the tonic contractile response of longitudinal muscle strips of guinea pig ileum was determined. 2,6-Dimethyl-3,5-dicarbomethoxy-4-phenyl-1,4-dihydropyridine (13) and 13 ortho-, 15 meta-, and seven para-monosubstituted and 10 polysubstituted aromatic derivatives of 13 were studied. The pharmacological activities of the monosubstituted derivatives were best correlated by eq 10, log 1/C = 0.68 pi + 2.50 sigma m -0.47Lmeta -3.40B1para + 11.31, which had a correlation coefficient of 0.89. The full data set was best correlated by eq 11, log 1/C = 0.62 pi + 1.96 sigma m -0.44Lmeta -3.26B1para -1.51Lmeta' + 14.23, which had a correlation coefficient of 0.90. Equations of similar form but involving an ortho steric term were found to correlate the radioligand binding data for this class of compounds.