2-((3-aminophenyl)thio)ethanol | 27122-79-8

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 2-((3-aminophenyl)thio)ethanol
• 英文别名: meta-(2-hydroxyethylthio)aniline；3-(2-hydroxyethylsulfanyl)aniline；2-(3-aminophenyl)sulfanylethanol
• CAS: 27122-79-8
• 化学式: C₈H₁₁NOS
• 分子量: 169.247
• InChiKey: DGUUUMZJGDNBAC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  71.6
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-((3-aminophenyl)thio)ethanol 在 间氯过氧苯甲酸 、 二甲基硫 作用下， 以 二氯甲烷 为溶剂， 反应 15.83h， 生成 6-(2-bromo-phenyl)-2-[3-(2-hydroxy-ethylsulfanyl)-phenylamino]-pyrido[2,3-d]pyrimidine-7-carboxylic acid (2-methanesulfonylamino-ethyl)-amide
  参考文献：
  名称：

  [EN] PYRIDO[2,3-D]PYRIMIDIN-7-CARBOXYLIC ACID DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS
  [FR] DERIVES D'ACIDE PYRIDO[2,3-D]PYRIMIDINE-7-CARBOXYLIQUE, LEUR FABRICATION ET LEUR UTILISATION EN TANT QU'AGENTS PHARMACEUTIQUES

  摘要：

  公开号：

  WO2004085436A3

文献信息

• [EN] NOVEL DICHLORO-PHENYL-PYRIDO [2,3-D] PYRIMIDINE DERIVATES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS<br/>[FR] DERIVES DE DICHLORO-PHENYL-PYRIDO [2,3-D] PYRIMIDINE, FABRICATION DE CEUX-CI ET UTILISATION DE CEUX-CI COMME AGENTS PHARMACEUTIQUES
  申请人：HOFFMANN LA ROCHE

  公开号：WO2005090344A1

  公开（公告）日：2005-09-29

  The invention describes compounds of the general formula (I), a process for their manufacture, medicaments containing them and their manufacture as well as the use of these compounds as pharmaceutically active agents. The said compounds show activity as protein kinase inhibitors, in particular src family tyrosine kinase inhibitors, and may therefore be useful for the treatment of diseases mediated by said tyrosine kinases.

  本发明描述了通式(I)的化合物、它们的制造工艺、含有它们的药物及其制造方法，以及这些化合物作为药物活性剂的使用。所述化合物作为蛋白激酶抑制剂，特别是src家族酪氨酸激酶抑制剂，显示出活性，因此可能用于治疗由所述酪氨酸激酶介导的疾病。
• [EN] INDAZOLYL-PYRIMIDINES AS KINASE INHIBITORS<br/>[FR] INDAZOLYL-PYRIMIDINES UTILISÉS EN TANT QU'INHIBITEURS DE KINASE
  申请人：GLAXO GROUP LTD

  公开号：WO2011120025A1

  公开（公告）日：2011-09-29

  Disclosed are compounds having the formula: or a salt thereof, wherein A, n, R1, R1A, and R2 are as defined herein, and methods of making and using the same.

  揭示了具有以下公式的化合物：或其盐，其中A、n、R1、R1A和R2如本文所定义，并且揭示了制备和使用这些化合物的方法。
• [EN] KINASE INHIBITORS<br/>[FR] INHIBITEURS DE KINASE
  申请人：RESPIVERT LTD

  公开号：WO2014076484A1

  公开（公告）日：2014-05-22

  There are provided compounds of formula I, (I) wherein R1 to R5, Ar and X1 to X3 have meanings given in the description, which compounds have antiinflammatory activity (e.g. through inhibition of one or more of members of: the family of p38 mitogen-activated protein kinase enzymes; Syk kinase; and members of the Src family of tyrosine kinases) and have use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, eye and intestines.

  提供了化合物I的化合物，化合物I的化合物中R1至R5，Ar以及X1至X3具有描述中给定的含义，这些化合物具有抗炎活性（例如通过抑制p38丝裂原活化蛋白激酶酶家族中的一个或多个成员；Syk激酶；以及酪氨酸激酶Src家族的成员之一）并且在治疗中有用，包括在药物组合中，特别是用于治疗炎症性疾病，包括肺部、眼睛和肠道的炎症性疾病。
• Pyrido[2,3-d]pyrimidin-7-carboxylic acid derivatives, their manufacture and use as pharmaceutical agents
  申请人：Honold Konrad

  公开号：US20050130984A1

  公开（公告）日：2005-06-16

  The invention describes compounds of the general formula I a process for their manufacture, medicaments containing them and their manufacture as well as the use of these compounds as pharmaceutically active agents. The compounds show activity as protein kinase inhibitors, in particular src family tyrosine kinase inhibitors, and may therefore be useful for the treatment of diseases mediated by said tyrosine kinases.

  本发明描述了一般式化合物I的制备方法，含有它们的药物及其制备方法，以及这些化合物作为药物活性剂的用途。该化合物表现出蛋白激酶抑制剂的活性，特别是src家族酪氨酸激酶抑制剂，因此可用于治疗由这些酪氨酸激酶介导的疾病。
• Dichloro-phenyl derivatives
  申请人：Honold Konrad

  公开号：US20060014765A1

  公开（公告）日：2006-01-19

  The invention describes compounds of the general formula I a process for their manufacture, compositions containing them and their manufacture as well as the use of these compounds as pharmaceutically active agents. These compounds show activity as protein kinase inhibitors, in particular src family tyrosine kinase inhibitors, and may therefore be useful for the treatment of diseases mediated by said tyrosine kinases.

  该发明描述了一般式化合物I的制备方法，包含它们的组成物和制备方法，以及这些化合物作为药物活性剂的用途。这些化合物表现出蛋白激酶抑制剂的活性，特别是src家族酪氨酸激酶抑制剂，因此可能有助于治疗由这些酪氨酸激酶介导的疾病。