1-[6-[[2-(1,3-benzothiazol-2-yl)phenoxy]methyl]pyridin-2-yl]-N,N-bis(pyridin-2-ylmethyl)methanamine | 1414968-71-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 英文名称: 1-[6-[[2-(1,3-benzothiazol-2-yl)phenoxy]methyl]pyridin-2-yl]-N,N-bis(pyridin-2-ylmethyl)methanamine
• CAS: 1414968-71-0
• 化学式: C₃₂H₂₇N₅OS
• 分子量: 529.665
• InChiKey: GVFZWWYFKRSCEY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  39
• 可旋转键数：
  10
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  92.3
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  2-(2-羟基苯基)苯并噻唑 、 1-(6-(chloromethyl)pyridin-2-yl)-N,N-bis((pyridin-2-yl)methyl)methanamine 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以90%的产率得到1-[6-[[2-(1,3-benzothiazol-2-yl)phenoxy]methyl]pyridin-2-yl]-N,N-bis(pyridin-2-ylmethyl)methanamine
  参考文献：
  名称：

  Reactive Probes for Ratiometric Detection of Co²⁺ and Cu⁺ Based on Excited-State Intramolecular Proton Transfer Mechanism

  摘要：

  An excited-state intramolecular proton transfer (ESIPT) mechanism based two reactive probes HBTCo and HBTCu is reported for the selective detection of Co2+ and Cu+ respectively in a reducing aqueous environment. Co2+ and Cu+ mediated oxidative benzylic ether (C-O) bond cleavage offers ratiometric detection of these metal ions.

  DOI：

  10.1021/ol302904c

文献信息

• Molecular probes for ascorbate detection and methods of use
  申请人：The University of Hong Kong

  公开号：US10018623B1

  公开（公告）日：2018-07-10

  Described are metal complexes for the selective detection of ascorbic acid or ascorbate. The metal complexes act as molecular sensors, and are useful in detecting ascorbate in live biological samples, commercial samples, or both. The selective ascorbate sensing involves an ascorbate-selective bond cleavage reaction. The bond cleavage is not limited to the construction of molecular sensors, but also includes other stimuli-responsive materials, i.e., materials that adopt a physical state, such as gel formation, upon ascorbate-selective bond cleavage of the metal complexes.

  描述了用于选择性检测抗坏血酸或抗坏血酸的金属配合物。这些金属配合物作为分子传感器，可用于检测活体生物样本、商业样本或两者中的抗坏血酸。选择性抗坏血酸传感涉及抗坏血酸选择性断裂键反应。这种键的断裂不仅限于构建分子传感器，还包括其他刺激响应材料，即在金属配合物的抗坏血酸选择性断裂键反应后采用物理状态（如凝胶形成）的材料。