5,5'-Ureylen-disalicylsaeure | 19862-84-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5,5'-Ureylen-disalicylsaeure
• 英文别名: 6,6'-dihydroxy-3,3'-ureylene-di-benzoic acid；6,6'-Dihydroxy-3,3'-ureylen-di-benzoesaeure；N.N'-Carbonyl-bis-(5-amino-salicylsaeure)；N.N'-Bis-(4-oxy-3-carboxy-phenyl)-harnstoff；5-{[(3-Carboxy-4-hydroxyanilino)carbonyl]amino}-2-hydroxybenzoic acid；5-[(3-carboxy-4-hydroxyphenyl)carbamoylamino]-2-hydroxybenzoic acid
• CAS: 19862-84-1
• 化学式: C₁₅H₁₂N₂O₇
• 分子量: 332.269
• InChiKey: OBCPVSPBAJBCLP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  156
• 氢给体数：
  6
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  5-uriedosalicylic acid 生成 5,5'-Ureylen-disalicylsaeure
  参考文献：
  名称：

  Griess, Journal fur praktische Chemie (Leipzig 1954), 1870, vol. <2> 1, p. 235

  摘要：

  DOI：

文献信息

• AROMATIC CARBOXYLIC ACID DERIVATIVES FOR TREATMENT AND PROPHYLAXIS OF GASTROINTESTINAL DISEASES INCLUDING COLON CANCERS
  申请人：Ekwuribe Nnochiri

  公开号：US20110319267A1

  公开（公告）日：2011-12-29

  Prodrug compounds which metabolize into 5-ASA or analogs thereof, and taurine or analogs thereof, in the colon site are disclosed. Pharmaceutical compositions including the compounds, and methods of treatment using the compounds, are also disclosed. Such compounds have utility for treating or preventing gastrointestinal disorders, including colon cancer, ulcerative colitis and Crohn's disease.
• US8569466B2
  申请人：——

  公开号：US8569466B2

  公开（公告）日：2013-10-29
• US9155748B2
  申请人：——

  公开号：US9155748B2

  公开（公告）日：2015-10-13
• [EN] AROMATIC CARBOXYLIC ACID DERIVATIVES FOR TREATMENT AND PROPHYLAXIS OF GASTROINTESTINAL DISEASES INCLUDING COLON CANCER<br/>[FR] DÉRIVÉS ACIDES CARBOXYLIQUES AROMATIQUES DESTINÉS AU TRAITEMENT ET À LA PROPHYLAXIE DE MALADIES GASTRO-INTESTINALES COMPRENANT LE CANCER DU COLON
  申请人：NUMED INTERNATIONAL INC

  公开号：WO2010030781A2

  公开（公告）日：2010-03-18

  Prodrug compounds which metabolize into 5-ASA or analogs thereof, and taurine or analogs thereof, in the colon site are disclosed. Pharmaceutical compositions including the compounds, and methods of treatment using the compounds, are also disclosed. Such compounds have utility for treating or preventing gastrointestinal disorders, including colon cancer, ulcerative colitis and Crohn's disease.
• Griess, Journal fur praktische Chemie (Leipzig 1954), 1870, vol. <2> 1, p. 235
  作者：Griess

  DOI：——

  日期：——