| 607390-49-8

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• CAS: 607390-49-8
• 化学式: C₃₁H₃₀N₄O₉S
• 分子量: 634.667
• InChiKey: JGAZYMIDOXJWOU-MWYPNJJNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.88
• 重原子数：
  45.0
• 可旋转键数：
  11.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  179.31
• 氢给体数：
  3.0
• 氢受体数：
  11.0

反应信息

• 作为反应物：
  描述：

  在 吡啶 、 肼 作用下， 以 甲醇 为溶剂， 反应 5.0h， 生成 1-{(2R,3R,4R,5R)-3-[4-Amino-2-(2-amino-ethyl)-butylsulfanyl]-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-1H-pyrimidine-2,4-dione
  参考文献：
  名称：

  Nylon/DNA:  Single-Stranded DNA with a Covalently Stitched Nylon Lining

  摘要：

  The synthesis of DNA/nylon ladder oligomers is described. Three stages of the development are addressed: the synthesis of 2'-beta-substituted phosphoramidites, the deprotection/purification protocols of ODNs modified with both amino and carboxyl groups, and amide bond-forming reactions on the ODNs. The established technology and the novel DNA-based ladder oligomer structure opens a pathway to the synthesis of topological molecular objects and networks templated by DNA through versatile DNA nanotechnology. The DNA-based ladder oligomers may find application in the antisense area.

  DOI：

  10.1021/ja035186r
• 作为产物：
  描述：

  2'-deoxy-2'-(4-methoxybenzylthio)uridine 在 N,N-二异丙基乙胺 、 三氟乙酸 、 苯酚 作用下， 以 乙腈 为溶剂， 反应 18.0h， 生成
  参考文献：
  名称：

  Nylon/DNA:  Single-Stranded DNA with a Covalently Stitched Nylon Lining

  摘要：

  The synthesis of DNA/nylon ladder oligomers is described. Three stages of the development are addressed: the synthesis of 2'-beta-substituted phosphoramidites, the deprotection/purification protocols of ODNs modified with both amino and carboxyl groups, and amide bond-forming reactions on the ODNs. The established technology and the novel DNA-based ladder oligomer structure opens a pathway to the synthesis of topological molecular objects and networks templated by DNA through versatile DNA nanotechnology. The DNA-based ladder oligomers may find application in the antisense area.

  DOI：

  10.1021/ja035186r