N,N'-Bis-[2-(3,4-dimethoxy-phenyl)-ethyl]-N,N'-dimethyl-propane-1,3-diamine | 141991-88-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N,N'-Bis-[2-(3,4-dimethoxy-phenyl)-ethyl]-N,N'-dimethyl-propane-1,3-diamine
• 英文别名: N,N'-Bis(2-(3,4-dimethoxyphenyl)ethyl)-N,N'-dimethylpropane-1,3-diamine；N,N'-bis[2-(3,4-dimethoxyphenyl)ethyl]-N,N'-dimethylpropane-1,3-diamine
• CAS: 141991-88-0
• 化学式: C₂₅H₃₈N₂O₄
• 分子量: 430.588
• InChiKey: NIPJEFAVJUDPJW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  31
• 可旋转键数：
  14
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  N-甲基-2-(3,4-二甲氧基苯基)乙胺 、 1,3-二溴丙烷 在 sodium carbonate 作用下， 以 苯 为溶剂， 生成 N,N'-Bis-[2-(3,4-dimethoxy-phenyl)-ethyl]-N,N'-dimethyl-propane-1,3-diamine
  参考文献：
  名称：

  DD122967

  摘要：

  公开号：

文献信息

• [EN] A PROCESS FOR THE PREPARATION OF VERAPAMIL HYDROCHLORIDE<br/>[FR] PROCÉDÉ DE PRÉPARATION DE CHLORHYDRATE DE VÉRAPAMIL
  申请人：PIRAMAL ENTPR LTD

  公开号：WO2016181292A1

  公开（公告）日：2016-11-17

  The present invention relates to a process for the preparation of 5-(3,4-dimethoxyphenylethyl) methyl-amino-2-(3,4-dimethoxyphenyl)-2-isopropyl valeronitrile, which is known as Verapamil. The present invention also relates to a process for improving the purity of verapamil and therefore of its hydrochloride represented as the compound of formula I, by efficient removal of the impurities formed, affording a product of purity greater than 99 %. The process of the present invention is simple, efficient, cost-effective and industrially feasible.

  本发明涉及一种制备5-(3,4-二甲氧基苯乙基)甲基氨基-2-(3,4-二甲氧基苯基)-2-异丙基戊腈的方法，该化合物被称为维拉帕米。本发明还涉及一种提高维拉帕米及其盐酸盐（化学式I）纯度的方法，通过有效去除形成的杂质，得到纯度大于99％的产品。本发明的方法简单、高效、具有成本效益和工业可行性。
• A convenient One-Pot Synthesis of an Unsymmetrical Propane-1,3-diamine BRL 61010A
  作者：Robin P Attrill、Thomas W Ramsay、Graham R Slater、Paul Smith

  DOI：10.1080/00397919908086040

  日期：1999.3

  The one-pot condensation of N-methylhomoveratrylamine with acrolein followed by in situ reductive amination with 3,4-dimethoxyaniline to give an unsymmetrical propane 1,3-diamine in excellent yield is described.
• A PROCESS FOR THE PREPARATION OF VERAPAMIL HYDROCHLORIDE
  申请人：PIRAMAL ENTERPRISES LIMITED

  公开号：US20180127354A1

  公开（公告）日：2018-05-10

  A process for the preparation of 5-(3,4-dimethoxyphenylethyl) methyl-amino-2-(3,4-dimethoxyphenyl)-2-isopropyl valeronitrile, which is known as Verapamil is described. A process for improving the purity of verapamil and therefore of its hydrochloride represented as the compound of formula I, by efficient removal of the impurities formed, affording a product of purity greater than 99% is described.
• DD122967
  申请人：——

  公开号：——

  公开（公告）日：——