[Cu(II)(2,2′-bipyridine)₂(NO₃)](NO₃) | 125993-61-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: [Cu(II)(2,2′-bipyridine)₂(NO₃)](NO₃)
• 英文别名: Cu(2,2′-bipyridine)₂(NO₃)₂；[Cu(2,2'-bipyridine)₂(NO₃)]NO₃；Cu(2,2′-bpy)₂(NO₃)NO₃；[Cu(II)(bpy)₂(NO₃)](NO₃)；[Cu(bipyridyl)2][NO3]2；[Cu(bpy)2][NO3]2；Bis(2,2'-bipyridine)nitratocopper(II) nitrate；copper;2-pyridin-2-ylpyridine;dinitrate
• CAS: 125993-61-5；17456-28-9；219797-27-0；25604-30-2；27625-18-9；455268-85-6；49726-37-6
• 化学式: C₂₀H₁₆CuN₅O₃*NO₃
• 分子量: 499.93
• InChiKey: NXBARPQJWGUZEG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.81
• 重原子数：
  33
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  177
• 氢给体数：
  0
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  [Cu(II)(2,2′-bipyridine)₂(NO₃)](NO₃) 生成 copper(II) oxide
  参考文献：
  名称：

  Thermogravimetric studies on some Cu(II) amine complexes

  摘要：

  DOI：

  10.1007/bf01913026
• 作为产物：
  描述：

  copper(II) nitrate 在 (C₅H₄N)2 作用下， 以 乙醇 、 水 为溶剂， 生成 [Cu(II)(2,2′-bipyridine)₂(NO₃)](NO₃)
  参考文献：
  名称：

  Thermogravimetric studies on some Cu(II) amine complexes

  摘要：

  DOI：

  10.1007/bf01913026

文献信息

• Reactivity of thiazolidine-2-thione towards CuI/CuII: Synthesis and structures of [3-(2-thiazolin-2-yl)thiazolidine-2-thione]copper(I) bromide and [bis(2,2′-bipyridine)nitratocopper(II)] nitrate
  作者：TARLOK S LOBANA、ANU RANI、AMANPREET K JASSAL、JERRY P JASINSKI

  DOI：10.1007/s12039-014-0760-3

  日期：2015.1

  earlier. Treatment of 1a with bis(diphenylphosphino)methane (dppm) in dichloromethane also formed [3-(2-thiazolin-2-yl)thiazolidine-2-thione]copper(I) bromide 1b but it crystallized into the triclinic system with a new space group, P-1: 296(2) K, a, 7.3890(19); b, 8.473(2); c, 9.491(2) Å; α, 70.273(5); β, 67.170(5); γ, 84.949(5)∘; R, 6.79%. Reactions of copper(II) nitrate with thiazolidine-2-thione followed

  噻唑烷-2-硫酮（L 1，NC 3 H 5 S 2）在有氧条件下与溴化铜（I）在CH 3 CN中反应，并通过C–S键断裂转化为3-（2-噻唑啉-2-基）噻唑烷-2-硫酮（L 2，C 3 H 4 S 2 N-C 3 H 4 SN）。该具有Cu I离子的硫配体L 2产生三坐标络合物，[3-（2-噻唑啉-2-基）噻唑烷-2-硫酮]溴化铜（I）1a，在具有空间基团的三斜晶系​​中结晶。如先前报道的P1。治疗1a与二（二苯基膦基）甲烷（dppm）的二氯甲烷溶液也形成了[3-（2-噻唑啉-2-基）噻唑烷-2-硫酮]溴化铜（I）1b，但结晶成具有新空间基的三斜晶系​​， P-1：296（2）K，a，7.3890（19）； P。b，8.473（2）；c，9.491（2）Å; α，70.273（5）; β，67.170（5）; γ，84.949（5）∘ ; R，6.79％。与铜的反应（II），硝酸噻唑烷-2-硫酮，然后加入2
• DFT analysis and DNA binding, cleavage of copper(II) complexes
  作者：S. Baskaran、M. Murali Krishnan、M.N. Arumugham、Rakesh Kumar

  DOI：10.1016/j.molliq.2016.06.055

  日期：2016.9

  Especially the complex 1, strongly bind to calf-thymus DNA. The intrinsic binding constants of the copper(II) complexes with CT-DNA are 1.42 × 105 M− 1 and 1.18 × 104 M− 1 for 1 and 2, respectively. Also, the cleavage of pBR322 DNA with copper(II) complexes was studied using gel electrophoresis method. The complexes were shown to be a partial intercalation mode of binding into DNA.

  三元铜（II）配合物[Cu（phen）（L -Ser）H 2 O]（NO 3）（1）和[Cu（bpy）2 NO 3 ]（NO 3）（2）（phen = 1，已合成10-菲咯啉（L -Ser = L-丝氨酸，bpy = 2,2'-联吡啶），并通过元素分析，红外，紫外可见和单晶X射线晶体学和DFT研究对其结构进行了表征。配合物显示出扭曲的方金字塔形（4 +1）CuN 3 O 2，CuN 4 O配位球。本复合物的最佳结构已经使用DFT / B3LYP / 6-31G研究⁎（d，p）/ LANL2DZ理论水平。理论上通过混合DFT方法检查了振动分配和HOMO-LUMO。配合物与小牛胸腺DNA（CT-DNA）的相互作用已通过UV-Vis吸收滴定，溴化乙锭置换法，粘度滴定实验和循环伏安法研究。特别是复合物1与小牛胸腺DNA牢固结合。铜（II）与CT-DNA配合物的内在结合常数为1.42×10 5  M
• DNA cleavage induced by [Cu(L)x(NO3)2] (L=2,2′-dipyridylamine, 2,2′-bipyridine, dipicolylamine, x=1 or 2): Effect of the ligand structure
  作者：Ji Hye Kwon、Hee-Jin Park、Nataraj Chitrapriya、Tae-Sub Cho、Soojin Kim、Jinheung Kim、In Hong Hwang、Cheal Kim、Seog K. Kim

  DOI：10.1016/j.jinorgbio.2013.10.023

  日期：2014.2

  and [Cu(dipicolylamine)2(NO3)2] complexes (complex 1, 2 and 3, respectively) in oxidative DNA cleavage was examined by electrophoresis and linear dichroism (LD). Among the three Cu complexes, complex 1 showed the highest efficiency in super-coiled DNA (scDNA) cleavage in electrophoresis. The presence of tiron, a superoxide radical scavenger, suppressed the reaction almost completely. The LD signal

  [Cu（2,2'-联吡啶）2（NO 3）] NO 3，[Cu（2,2'-联吡啶胺）2（NO 3）2 ]和[Cu（dipicolylamine）2（NO 3）的效率）2通过电泳和线性二色性（LD）检测氧化DNA切割中的复合物（分别为复合物1、2和3）。在这三种铜配合物中，配合物1在电泳中的超螺旋DNA（scDNA）切割中显示出最高的效率。铁离子（一种超氧化物自由基清除剂）的存在几乎完全抑制了反应。随着时间的流逝，260 nm处的LD信号逐渐减小。LD幅值的减小最好通过两条单指数曲线的总和来解释。这表明裂解反应涉及两个一级动力学过程。由于其中一条链的断裂而增加了柔韧性，并且由于双链DNA（dsDNA）的两条链都被切断而导致了DNA茎的缩短。与电泳数据一致，配合物1表现出最高的效率，而超氧自由基是必需的活性氧。scDNA和dsDNA的效率顺序如下：复合物1>复合物2>复合物3。尽管中心Cu离子的
• Prabhumirashi; Khoje, Indian Journal of Chemistry, Section A: Inorganic, Physical, Theoretical and Analytical, 2004, vol. 43, # 2, p. 299 - 302
  作者：Prabhumirashi、Khoje

  DOI：——

  日期：——
• Real-time detection of DNA cleavage induced by [M(2,2′-bipyridine)2(NO3)](NO3) (M=Cu(II), Zn(II) and Cd(II)) complexes using linear dichroism technique
  作者：Hee-Jin Park、Ji Hye Kwon、Tae-Sub Cho、Jong Moon Kim、In Hong Hwang、Cheal Kim、Soojin Kim、Jinheung Kim、Seog K. Kim

  DOI：10.1016/j.jinorgbio.2013.06.007

  日期：2013.10

  The catalytic effect of [M(2,2'-bipyridine)(2)(NO3)](NO3) (M(bpy)(2), M = Cu(II), Zn(II) and Cd(II)) on the supercoiled and double stranded DNA (scDNA and dsDNA) was examined by electrophoresis and a real-time detection linear dichroism (LD) technique. Although the Cu(bpy)(2) complex effectively cleaved both types of DNA, the other two complexes were inactive. This was explained by the electrochemical properties of the metal complexes. The Cu(bpy)(2) complex exhibited a redox potential at -0.222 V with a peak to peak separation of 0.201 V, whereas the other two metal complexes did not undergo any redox reaction. Both electrophoresis and LD measurements revealed the superoxide radical, center dot O-2(-), to be responsible for DNA cleavage. A kinetic study using the LD technique showed that the cleavage of dsDNA consisted of two first order reactions. The fast reaction is believed to reflect the cleavage of one strand, whereas the slow reaction involves the cleavage of the complementary strand at or near the first cleaved site. (c) 2013 The Authors. Published by Elsevier Inc. All rights reserved.