[2-amino-2'-(N-tert-butoxycarbonylamino)]biphenyl | 1096704-80-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [2-amino-2'-(N-tert-butoxycarbonylamino)]biphenyl
• 英文别名: 2-amino-2'-t-butoxycarbonylaminobiphenyl；tert-butyl N-[2-(2-aminophenyl)phenyl]carbamate
• CAS: 1096704-80-1
• 化学式: C₁₇H₂₀N₂O₂
• 分子量: 284.358
• InChiKey: GQGRRBHRCSSOMH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  64.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  [2-amino-2'-(N-tert-butoxycarbonylamino)]biphenyl 在 potassium carbonate 、 三氟乙酸 作用下， 以 二氯甲烷 、 水 、 乙腈 为溶剂， 反应 60.0h， 生成
  参考文献：
  名称：

  Gd Complexes of DO3A-(Biphenyl-2,2′-bisamides) Conjugates as MRI Blood-Pool Contrast Agents

  摘要：

  We report the synthesis of DO3A derivatives of 2,2'-diaminobiphenyl (1a,b) and their Gd complexes of the type [Gd(1)(H2O)]center dot xH(2)O (2a,b) for use as new MRI blood-pool contrast agents (BPCAs) that provide strong and prolonged vascular enhancement. Pharmacokinetic inertness of 2 compares well with that of structurally related Dotarem, a DOTA-based MRI CA currently in use. The R-1 relaxivity in water reaches 7.3 mM(-1) s(-1), which is approximately twice as high as that of Dotarem (R-1 = 3.9 mM(-1) s(-1)). They show interaction with HSA to give association constants (K-a) in the order of two (similar to 10(2)), revealing the existence of the blood-pool effect. The in vivo MR images of mice obtained with 2 are coherent, showing strong signal enhancement in both heart, abdominal aorta, and small vessels. Furthermore, the brain tumor is vividly enhanced for an extended period of time.

  DOI：

  10.1021/ml300223b
• 作为产物：
  描述：

  二碳酸二叔丁酯 、 2,2-联苯二胺 在 sodium carbonate 作用下， 以 1,4-二氧六环 、 水 为溶剂， 反应 30.0h， 以50%的产率得到[2-amino-2'-(N-tert-butoxycarbonylamino)]biphenyl
  参考文献：
  名称：

  TRANSITION METAL COMPLEX COMPOUND, OLEFIN OLIGOMERIZATION CATALYST CONTAINING THE COMPOUND, AND METHOD FOR PRODUCING OLEFIN OLIGOMER PERFORMED IN THE PRESENCE OF THE CATALYST

  摘要：

  公开号：

  EP2174928B1

文献信息

• METHOD FOR PRODUCING BIARYL COMPOUND
  申请人：Sato Koichi

  公开号：US20100087680A1

  公开（公告）日：2010-04-08

  A method for producing a biaryl compound, comprising reacting an aromatic organic compound with at least one compound selected from the group consisting of aromatic organoboron compounds and boroxine compounds, in the presence of a zero-valent nickel catalyst, phosphine ligand and base.

  一种制备双芳基化合物的方法，包括在零价镍催化剂、膦配体和碱的存在下，将芳香有机化合物与选自芳香基有机硼化合物和硼氧化物化合物组的至少一种化合物反应。
• PROCESS FOR PRODUCING BIARYL COMPOUND
  申请人：Sumitomo Chemical Company, Limited

  公开号：EP1914221A1

  公开（公告）日：2008-04-23

  A method for producing a biaryl compound, comprising reacting an aromatic organic compound with at least one compound selected from the group consisting of aromatic organoboron compounds and boroxine compounds, in the presence of a zero-valent nickel catalyst, phosphine ligand and base.

  一种生产双芳基化合物的方法，包括在零价镍催化剂、膦配体和碱存在下，使芳香族有机化合物与至少一种选自由芳香族有机硼化合物和硼氧化合物组成的组中的化合物反应。
• TRANSITION METAL COMPLEX COMPOUND, OLEFIN POLYMERIZATION CATALYST CONTAINING THE COMPOUND, AND METHOD FOR PRODUCING OLEFIN POLYMER PERFORMED IN THE PRESENCE OF THE CATALYST
  申请人：Mitsui Chemicals, Inc.

  公开号：EP2174928A1

  公开（公告）日：2010-04-14

  The invention provides transition metal complex compounds, high-activity olefin oligomerization catalysts containing the compounds, and olefin oligomerization processes using the catalysts. A transition metal complex compound [A] according to the invention is represented by Formula (I) or Formula (I') below. An olefin oligomerization catalyst includes the transition metal complex compound [A]. In an olefin oligomerization process of the invention, an olefin is oligomerized in the presence of the catalyst.

  本发明提供了过渡金属络合物、含有该化合物的高活性烯烃低聚催化剂以及使用该催化剂的烯烃低聚工艺。 根据本发明的过渡金属络合物 [A] 由下式 (I) 或式 (I') 表示。烯烃低聚催化剂包括过渡金属配合物[A]。在本发明的烯烃低聚工艺中，烯烃在催化剂存在下进行低聚。
• TRANSITION METAL COMPLEX COMPOUND, OLEFIN OLIGOMERIZATION CATALYST CONTAINING THE COMPOUND, AND METHOD FOR PRODUCING OLEFIN OLIGOMER PERFORMED IN THE PRESENCE OF THE CATALYST
  申请人：Mitsui Chemicals, Inc.

  公开号：EP2174928B1

  公开（公告）日：2015-03-11
• TRANSITION METAL COMPLEX COMPOUNDS, OLEFIN OLIGOMERIZATION CATALYSTS INCLUDING THE COMPOUNDS, AND PROCESSES FOR PRODUCING OLEFIN OLIGOMERS USING THE CATALYSTS
  申请人：Suzuki Yasuhiko

  公开号：US20110082325A1

  公开（公告）日：2011-04-07

  The invention provides transition metal complex compounds, high-activity olefin oligomerization catalysts containing the compounds, and olefin oligomerization processes using the catalysts. A transition metal complex compound [A] according to the invention is represented by Formula (I) or Formula (I′) below. An olefin oligomerization catalyst includes the transition metal complex compound [A]. In an olefin oligomerization process of the invention, an olefin is oligomerized in the presence of the catalyst.