N,N-dimethyl-N'-methyl-N'-phenylurea | 32773-27-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N,N-dimethyl-N'-methyl-N'-phenylurea
• 英文别名: N-phenyl-N,N',N'-trimethylurea；N,N,N'-trimethyl-N'-phenylurea；N,N,N'-Trimethyl-N'-phenylharnstoff；Phenyl-trimethyl-harnstoff；N,N',N'-trimethyl-N-phenyl urea；1,1,3-trimethyl-3-phenylurea
• CAS: 32773-27-6
• 化学式: C₁₀H₁₄N₂O
• 分子量: 178.234
• InChiKey: TTZPPHVMXXHUBH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  23.6
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N,N-dimethyl-N'-methyl-N'-phenylurea 在 sodium hydrogensulfide 作用下， 生成 1,1,3-三甲基-3-苯基硫脲
  参考文献：
  名称：

  Eilingsfeld,H. et al., Angewandte Chemie, 1960, vol. 72, # 22, p. 836 - 845

  摘要：

  DOI：
• 作为产物：
  描述：

  N-甲基-N-苯基氨基甲酰氯 、 二甲胺 以 N,N-二甲基甲酰胺 为溶剂， 生成 N,N-dimethyl-N'-methyl-N'-phenylurea
  参考文献：
  名称：

  Bradamante, Silvia; Colombo, Silvana; Pagani, Giorgio A., Gazzetta Chimica Italiana, 1981, vol. 111, # 7/8, p. 357 - 364

  摘要：

  DOI：

文献信息

• 1-(Heteroaryl)pyrazol-4-ylacetic acids, processes for their preparation and their use as herbicides and plant growth regulators
  申请人：Jakobi Harald

  公开号：US20110257014A1

  公开（公告）日：2011-10-20

  The invention provides compounds of the formula (I) and salts thereof which are described herein. The compounds (I) or salts thereof are suitable for use as herbicides and plant growth regulators, in particular as herbicides for the selective control of harmful plants in crops of useful plants, and can be prepared by the described processes.

  该发明提供了公式（I）的化合物及其盐，这些化合物适用于作为除草剂和植物生长调节剂，特别是作为对有用植物作物中有害植物的选择性控制除草剂，并且可以通过所述的方法制备。
• SUBSTITUTED 1-(THIAZOLYL)-AND 1-(ISOTHIAZOLYL)PYRAZOL-4-YLACETIC ACIDS, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS HERBICIDES AND PLANT GROWTH REGULATORS
  申请人：Martelletti Arianna

  公开号：US20100197501A1

  公开（公告）日：2010-08-05

  The invention relates to 1-(thiazolyl)- and 1-(isothiazolyl)pyrazol-4-ylacetic acid derivatives of the general formula (I) and salts thereof in which Het, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and n are as defined in claim 1. The compounds (I) or salts thereof are suitable for use as herbicides and plant growth regulators, in particular as herbicides for the selective control of harmful plants in crops of useful plants and can be prepared by processes as described in claim 9.

  这项发明涉及一般式(I)的1-(噻唑基)-和1-(异噻唑基)吡唑-4-基乙酸衍生物及其盐，其中Het，R1，R2，R3，R4，R5，R6和n如权利要求1所定义。化合物(I)或其盐适用于用作除草剂和植物生长调节剂，特别是作为对有用植物作物中有害植物的选择性控制除草剂，并且可以通过权利要求9中描述的方法制备。
• 2,3-DIPHENYL-VALERONITRILE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND USE THEREOF AS HERBICIDES AND PLANT GROWTH REGULATORS
  申请人：Mosrin Marc

  公开号：US20140235446A1

  公开（公告）日：2014-08-21

  The compounds of the formula (I) in which L represents a radical of the formula and A 1 , B 1 and A 2 and B 2 are as defined in Claim 1, are suitable as herbicides for the control of harmful plants or as plant growth regulators. The compounds can be prepared by the process of Claim 12.

  式(I)中L代表式的基团，A1、B1、A2和B2如权利要求1所定义，适用于作为除草剂用于控制有害植物或作为植物生长调节剂。这些化合物可以通过权利要求12所述的方法制备。
• Direct synthesis of 8-aryl tetrahydroquinolines via pd-catalyzed ortho-arylation of arylureas in water
  作者：Zhen Jiang、Lingjuan Zhang、Chaonan Dong、Xiaoming Su、Huanrong Li、Weijun Tang、Lijin Xu、Qinghua Fan

  DOI：10.1039/c2ra22901c

  日期：——

  An efficient protocol for the direct synthesis of 8-arylated tetrahydroquinolines via Pd-catalyzed ortho-arylation of aryl ureas with aryl iodides was developed. The reaction proceeded smoothly in water under ligand-free and surfactant-free conditions, providing the desired products in high yields with remarkable functional group tolerance.

  开发了一种高效的协议，通过钯催化的芳基脲与芳基碘的邻位芳基化反应，直接合成8-芳基化的四氢喹啉。该反应在无配体和无表面活性剂的水相条件下顺利进行，以高产率提供了所需产物，并具有显著的官能团耐受性。
• [EN] MODULATORS OF EUKARYOTIC INITIATION FACTOR 2<br/>[FR] MODULATEURS DU FACTEUR 2 D'INITIATION EUCARYOTE
  申请人：DENALI THERAPEUTICS INC

  公开号：WO2019183589A1

  公开（公告）日：2019-09-26

  The present disclosure relates generally to eukaryotic initiation factor 2B modulators of formula A, or a pharmaceutically acceptable salt, stereoisomer, or mixture of stereoisomers thereof and methods of making and using thereof.

  本公开涉及一般与配方A的真核起始因子2B调节剂有关，或其药用可接受盐、立体异构体或其立体异构体混合物，以及其制备和使用方法。