(2,4-Dichlor-6-formylphenoxy)essigsaeure | 16861-46-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2,4-Dichlor-6-formylphenoxy)essigsaeure
• 英文别名: 4,6-Dichlor-2-formyl-phenoxyessigsaeure；[(2,4-dichloro-6-formylphenyl)oxy]acetic acid；2-(2,4-Dichloro-6-formylphenoxy)acetic acid
• CAS: 16861-46-4
• 化学式: C₉H₆Cl₂O₄
• 分子量: 249.05
• InChiKey: OVOCPGBXSHLKPA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (2,4-Dichlor-6-formylphenoxy)essigsaeure 在 sodium hydroxide 、 sodium tetrahydroborate 作用下， 生成 4.6-Dichlor-2-hydroxymethyl-phenoxyessigsaeure
  参考文献：
  名称：

  磷酸吡rid醛。二。苯类似物。2-甲酰基苯氧基乙酸作为吡ido醛磷酸的潜在抗代谢物。

  摘要：

  DOI：

  10.1021/jm00303a018
• 作为产物：
  描述：

  2-(2,4-二氯-6-甲酰基苯氧基)乙酸乙酯 在 氢氧化钾 作用下， 以 甲醇 为溶剂， 生成 (2,4-Dichlor-6-formylphenoxy)essigsaeure
  参考文献：
  名称：

  (Vinylaryloxy)acetic acids. A new class of diuretic agents. 3. [(2-Nitro-1-alkenyl)aryloxy]acetic acids

  摘要：

  A series of [(2-nitro-1-alkenyl)aryloxy]acetic acids was synthesized and tested in dogs for saluretic and diuretic activity. A number of these compounds exhibit a high order of activity on iv or po administration; representative of these is (E)-[2,3-dichloro-4-(2-nitropropenyl)phenoxy]acetic acid (5). The most highly active compounds are qualitatively similar in action to [2,3-dichloro-4-(2-methylenebutyryl)phenoxylacetic acid (ethacrynic acid) in causing a prompt increase in the excretion of water and of sodium and chloride ions in approximately equimolar amounts but are three to five times as potent. Potassium ion excretion is increased but less markedly than sodium excretion.

  DOI：

  10.1021/jm00228a009

文献信息

• N-(4- carbamimidoyl-phenyl) -glycine derivatives
  申请人：——

  公开号：US20010001799A1

  公开（公告）日：2001-05-24

  The invention is concerned with novel N-(4-carbamimidoyl-phenyl)-glycine derivatives of the formula: 1 wherein R 1 , E, X 1 to X 4 and G 1 and G 2 are as defined in the description and the claims, as well as hydrates or solvates and physiologically usable salts thereof.

  这项发明涉及一种新颖的公式为N-(4-羰基苄基)-甘氨酸衍生物，其中R1、E、X1至X4以及G1和G2如描述和权利要求中所定义，以及其水合物或溶剂合物和生理可用盐。
• N- (4-carbamimidoyl-phenyl) -glycine derivatives
  申请人：——

  公开号：US20030083504A1

  公开（公告）日：2003-05-01

  The invention is concerned with novel N-(4-carbamimidoyl-phenyl)-glycine derivatives of the formula: 1 wherein R 1 , E, X 1 to X 4 and G 1 and G 2 are as defined in the description and the claims, as well as hydrates or solvates and physiologically usable salts thereof.

  本发明涉及一种新的N-(4-氨基甲酰基苯基)-甘氨酸衍生物，其化学式为：1，其中R1、E、X1至X4和G1和G2如说明书和权利要求所定义，以及其水合物或溶剂化合物和生理上可用的盐。
• Bi-functional complexes and methods for making and using such complexes
  申请人：Gouliaev Alex Haahr

  公开号：US11225655B2

  公开（公告）日：2022-01-18

  The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.

  本发明涉及一种合成双功能复合物的方法，该复合物包括分子部分和识别分子部分的识别寡核苷酸部分。根据本发明的合成方法的一部分优选在一种或多种有机溶剂中进行，此时包含可选保护标签或寡核苷酸标识符的新生双功能复合物与固体支持物相连接，合成方法的另一部分优选在适合于将寡核苷酸标签酶加到溶液中的新生双功能复合物的条件下进行。
• SCHULTZ E. M.; BICKING J. B.; DEANA A. A.; GOULD N. P.; STROBAUGH T. P.; +, J. MED. CHEM. <JMCM-AR>, 1976, 19, NO 6, 783-787
  作者：SCHULTZ E. M.、 BICKING J. B.、 DEANA A. A.、 GOULD N. P.、 STROBAUGH T. P.、 +

  DOI：——

  日期：——
• PHENYLGLYCINE DERIVATIVES
  申请人：F. HOFFMANN-LA ROCHE AG

  公开号：EP1149069A1

  公开（公告）日：2001-10-31