N-[[双(2-羟乙基)氨基]甲基]-5-氯-2-甲氧基苯甲酰胺 | 838836-51-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: N-[[双(2-羟乙基)氨基]甲基]-5-氯-2-甲氧基苯甲酰胺
• 英文名称: N-{[Bis-(2-hydroxy-ethyl)-amino]-methyl}-5-chloro-2-methoxy-benzamide
• 英文别名: N-{[Bis(2-hydroxyethyl)amino]methyl}-5-chloro-2-methoxybenzamide；N-[[bis(2-hydroxyethyl)amino]methyl]-5-chloro-2-methoxybenzamide
• CAS: 838836-51-4
• 化学式: C₁₃H₁₉ClN₂O₄
• 分子量: 302.758
• InChiKey: KXRDYJSXQXNSSB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  20
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  82
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  聚合甲醛 、 5-chloro-2-methoxybenzamide 、 二乙醇胺 以 乙醇 、 水 为溶剂， 反应 3.0h， 生成 N-[[双(2-羟乙基)氨基]甲基]-5-氯-2-甲氧基苯甲酰胺
  参考文献：
  名称：

  Synthesis and in vitro study of novel Mannich bases as antibacterial agents

  摘要：

  A series of novel Mannich bases derived from 5-chloro-2-methoxybenzamide and sulfonamides/amines have been synthesised and the antibacterial activities were evaluated against various Gram positive and Gram negative strains of bacteria. Some of the synthesized compounds showed superior in vitro activities as compared to their parent sulfonamides. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.09.084

文献信息

• Synthesis and in vitro study of novel Mannich bases as antibacterial agents
  作者：Sheela Joshi、Navita Khosla、Deepak Khare、Rakesh Sharda

  DOI：10.1016/j.bmcl.2004.09.084

  日期：2005.1

  A series of novel Mannich bases derived from 5-chloro-2-methoxybenzamide and sulfonamides/amines have been synthesised and the antibacterial activities were evaluated against various Gram positive and Gram negative strains of bacteria. Some of the synthesized compounds showed superior in vitro activities as compared to their parent sulfonamides. (C) 2004 Elsevier Ltd. All rights reserved.