N-Methyl-N-vinyl-benzylamin | 7026-00-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-Methyl-N-vinyl-benzylamin
• 英文别名: benzyl-methyl-vinyl-amine；N-vinylmethyl(phenylmethyl)amine；N-benzyl-N-methylethenamine
• CAS: 7026-00-8
• 化学式: C₁₀H₁₃N
• 分子量: 147.22
• InChiKey: QEHONTLIZRAESB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  N-甲基-N-羟乙基苄胺 生成 N-Methyl-N-vinyl-benzylamin
  参考文献：
  名称：

  Lattes,A.; Riviere,M., Comptes Rendus des Seances de l'Academie des Sciences, Serie C: Sciences Chimiques, 1966, vol. 262, p. 1797 - 1800

  摘要：

  DOI：

文献信息

• ANTIBODY DRUG CONJUGATES (ADCS) AND ANTIBODY PRODRUG CONJUGATES (APDCS) WITH ENZYMATICALLY CLEAVABLE GROUPS
  申请人：Bayer Pharma Aktiengesellschaft

  公开号：US20180169256A1

  公开（公告）日：2018-06-21

  The present invention relates to novel binder-prodrug conjugates (APDCs) where binders are conjugated with inactive precursor compounds of kinesin spindle protein inhibitors, and to antibody-drug conjugates ADCs and to processes for producing these APDCs and ADCs.

  这项发明涉及新型结合物-前药偶联物（APDCs），其中结合物与动力蛋白纺锤体抑制剂的非活性前体化合物偶联，以及抗体药物偶联物ADCs以及制备这些APDCs和ADCs的方法。
• ANTIBODY DRUG CONJUGATES OF KINESIN SPINDEL PROTEIN (KSP) INHIBITORS WITH ANTIB7H3-ANTIBODIES
  申请人：BAYER PHARMA AKTIENGESELLSCHAFT

  公开号：US20200138970A1

  公开（公告）日：2020-05-07

  The present application relates to novel binder drug conjugates (ADCs), to active metabolites of these ADCs, to processes for preparing these ADCs, to the use of these ADCs for the treatment and/or prophylaxis of diseases and to the use of these ADCs for preparing medicaments for treatment and/or prophylaxis of diseases, in particular hyperproliferative and/or angiogenic disorders such as, for example, cancer diseases. Such treatments can be effected as monotherapy or else in combination with other medicaments or further therapeutic measures.

  本申请涉及新型结合剂药物偶联物（ADCs），这些ADCs的活性代谢物，制备这些ADCs的过程，将这些ADCs用于治疗和/或预防疾病，以及将这些ADCs用于制备治疗和/或预防疾病的药物，特别是高增殖和/或血管生成异常等疾病，例如癌症等。这种治疗可以作为单独治疗，也可以与其他药物或其他治疗措施结合使用。
• Palladium nanoparticle catalysts in ionic liquids: synthesis, characterisation and selective partial hydrogenation of alkynes to Z-alkenes
  作者：Ramprakash Venkatesan、Martin H. G. Prechtl、Jackson D. Scholten、Rafael P. Pezzi、Giovanna Machado、Jairton Dupont

  DOI：10.1039/c0jm03557b

  日期：——

  The simple heating (120 °C) of Pd(OAc)2 in 1-butyronitrile-3-methylimidazolium-N-bis(trifluoromethane sulfonyl)imide ((BCN)MI·NTf2) under reduced pressure leads to the formation of stable and small-sized Pd(0)-NPs (diameter: 7.3 ± 2.2 nm). These metal nanoparticles were characterised by means of TEM, HRTEM and XPS analysis techniques. Moreover, the potential for partial hydrogenation of alkynes in multiphase systems was evaluated. The hydrogenation of internal alkynes at 25 °C and under 1 bar of hydrogen yields Z-alkenes (up to 98% selectivity). Application of higher hydrogen pressure (4 bar) in these reactions always led to the formation of alkanes without the detection of any alkenes. TOF values were attained up to 1282 h−1 with a good recyclability of the system which does not lose its activity for at least 4 runs.

  在减压条件下，将Pd(OAc)2在1-丁腈-3-甲基咪唑铵-N-双（三氟甲磺酰）氟化物（(BCN)MI·NTf2）中简单加热至120°C，导致形成稳定且小尺寸的Pd(0)-纳米颗粒（直径：7.3 ± 2.2 nm）。这些金属纳米颗粒通过透射电子显微镜（TEM）、高分辨率透射电子显微镜（HRTEM）和X射线光电子能谱（XPS）分析技术进行了表征。此外，评估了在多相体系中部分氢化炔烃的潜力。在25°C和1 bar氢气压力下，对内部炔烃进行氢化反应可获得Z-烯烃（最高98%的选择性）。在这些反应中施加更高的氢气压力（4 bar）始终导致烷烃的形成，而未检测到任何烯烃。反应的TOF值达到了1282 h−1，且该体系表现出良好的可回收性，在至少进行4次反应后仍保持其活性。
• PURIFICATION OF ALKENYL COMPOUNDS
  申请人：——

  公开号：US20020038059A1

  公开（公告）日：2002-03-28

  A process for purifying alkenyl compounds having a divalent or trivalent heteroatom in the &agr;-position relative to the double bond by distillation comprises carrying out at least two distillations in which the purified alkenyl compounds are obtained from the gas phase by condensation, where the time between the first distillation after the synthesis of the alkenyl compounds and at least one further distillation is at least one day and the purified alkenyl compounds have an APHA color number of <30.

  一种用蒸馏法纯化α-位于双键旁的含二价或三价杂原子的烯基化合物的方法，包括进行至少两次蒸馏，其中通过冷凝从气相中获得纯化的烯基化合物，第一次蒸馏后至少一次进一步蒸馏的时间至少为一天，纯化的烯基化合物的APHA色数小于30。
• NON-VIRAL DELIVERY AGENTS FROM POLYELECTROLYTES BASED ON CYCLOPROPENIUM IONS, THEIR SYNTHESES, AND USES THEREOF
  申请人：THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

  公开号：US20210283273A1

  公开（公告）日：2021-09-16

  Non-viral gene delivery agents can be provided comprising a polyamine comprising a polymer containing a secondary amine, wherein the polyamine and a derivative of a cyclopropenium ion that are covalently attached. The non-viral gene delivery agents can be formed by a click reaction combining a polyamine polymer precursor backbone with a trisaminocyclopropenium polymer. The non-viral gene delivery agents can be used to deliver genetic material to cells in mammals or other organisms as part of gene therapy.

  非病毒基因传递剂可以包含聚合物的多胺，其中包含含有次级胺的聚合物，其中多胺和环丙烯阳离子的衍生物共价连接。非病毒基因传递剂可以通过点击反应将多胺聚合物前体骨架与三氨基环丙烯聚合物结合而形成。非病毒基因传递剂可用于作为基因治疗的一部分将遗传物质传递到哺乳动物或其他生物的细胞中。