A panoramic view on synthetic applications of α-oxothioamides: a highly regioselective synthesis of 2-acyl-4-(het)arylthiazoles and thioethers
作者:Rajaghatta N. Suresh、Toreshettahally R. Swaroop、Darshini Gowda、Kempegowda Mantelingu、Kanchugarakoppal S. Rangappa
DOI:10.1039/d2ra08118k
日期:——
Highly regioselectivesynthesis of 2-acyl-4-(het)arylthiazoles and thioethers by the reaction between α-oxothioamides and α-bromoketones in the absence of base in DMF and in the presence of triethylamine in acetonitrile, respectively, has been reported. This thiazolesynthesis is an important extended work of the Hantzschthiazolesynthesis, which overcomes the drawbacks of earlier reported methods
Synthesis of 3,5-bis(acyl)-1,2,4-thiadiazoles via iodine mediated oxidative dimerization of α-oxothioamides
作者:Rajaghatta N. Suresh、Toreshettahally R. Swaroop、Veeresha Gowda Shalini、Kempegowda Mantelingu、Kanchugarakoppal S. Rangappa
DOI:10.1016/j.tetlet.2022.154302
日期:2023.2
A novel and an efficient method for the synthesis of 3,5-bis(acyl)-1,2,4-thiadiazoles by the oxidative cyclization of α-oxothioamides with assistance of moleculariodine has been reported. The required substrates – α-oxothioamides have been synthesized by the reaction of α-oxodithioesters with ammonium chloride and sodium acetate. The probable mechanism for the formation of products has presented.