(E)-6-chloro-2-(2-(4-(2,4-dichlorophenoxy)benzylidene)hydrazinyl)benzo[d]thiazole | 1355960-04-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (E)-6-chloro-2-(2-(4-(2,4-dichlorophenoxy)benzylidene)hydrazinyl)benzo[d]thiazole
• 英文别名: 6-chloro-N-[(E)-[4-(2,4-dichlorophenoxy)phenyl]methylideneamino]-1,3-benzothiazol-2-amine
• CAS: 1355960-04-1
• 化学式: C₂₀H₁₂Cl₃N₃OS
• 分子量: 448.76
• InChiKey: PAVHMKWZOHGGSB-BHGWPJFGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.7
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  74.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-氨基-6-氯苯并噻唑 在 一水合肼 作用下， 以 乙醇 、 乙二醇 为溶剂， 生成 (E)-6-chloro-2-(2-(4-(2,4-dichlorophenoxy)benzylidene)hydrazinyl)benzo[d]thiazole
  参考文献：
  名称：

  Novel 2-(2-(4-aryloxybenzylidene) hydrazinyl)benzothiazole derivatives as anti-tubercular agents

  摘要：

  A series of structurally novel, substituted 2-(2-(4-aryloxybenzylidene) hydrazinyl)benzothiazole derivatives incorporating 2-hydrazinyl benzothiazole and 4-(aryloxy)benzaldehyde were designed and synthesized using molecular hybridization approach. All the synthesized compounds exhibited promising activity (MIC 1.5-29.00 mu g/ml) against Mycobacterium tuberculosis H37Rv strains of using REMA. Five of the evaluated compounds exhibit MIC <3.0 mu g/ml. Compound (E)-6-chloro-2-(2-(4-(2,4-dichlorophenoxy) benzylidene) hydrazinyl) benzothiazole showed MIC of 1.5 mu g/ml. Thus, this compound could act as a potential lead for further development of new anti-tubercular drugs. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.10.064

文献信息

• Novel 2-(2-(4-aryloxybenzylidene) hydrazinyl)benzothiazole derivatives as anti-tubercular agents
  作者：Vikas N. Telvekar、Vinod Kumar Bairwa、Kalpana Satardekar、Anirudh Bellubi

  DOI：10.1016/j.bmcl.2011.10.064

  日期：2012.1

  A series of structurally novel, substituted 2-(2-(4-aryloxybenzylidene) hydrazinyl)benzothiazole derivatives incorporating 2-hydrazinyl benzothiazole and 4-(aryloxy)benzaldehyde were designed and synthesized using molecular hybridization approach. All the synthesized compounds exhibited promising activity (MIC 1.5-29.00 mu g/ml) against Mycobacterium tuberculosis H37Rv strains of using REMA. Five of the evaluated compounds exhibit MIC <3.0 mu g/ml. Compound (E)-6-chloro-2-(2-(4-(2,4-dichlorophenoxy) benzylidene) hydrazinyl) benzothiazole showed MIC of 1.5 mu g/ml. Thus, this compound could act as a potential lead for further development of new anti-tubercular drugs. (C) 2011 Elsevier Ltd. All rights reserved.