2-Chloro-4-(methoxymethoxymethyl)pyridine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-Chloro-4-(methoxymethoxymethyl)pyridine
• 化学式: C₈H₈ClFNPol
• 分子量: 187.62
• InChiKey: PFZCDDVWPWLWCF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  31.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-Chloro-4-(methoxymethoxymethyl)pyridine 生成 2-[(Z)-4-[4-(methoxymethoxymethyl)pyridin-2-yl]oxybut-2-enyl]isoindole-1,3-dione
  参考文献：
  名称：

  HIRAKAWA, NOBUHIKO;KASHIWABA, NORIAKI;MATSUMOTO, HAJIME;HOSODA, AKIHIKO;S+

  摘要：

  DOI：
• 作为产物：
  描述：

  (2-氯吡啶-4-基)甲醇 生成 2-Chloro-4-(methoxymethoxymethyl)pyridine
  参考文献：
  名称：

  HIRAKAWA, NOBUHIKO;KASHIWABA, NORIAKI;MATSUMOTO, HAJIME;HOSODA, AKIHIKO;S+

  摘要：

  DOI：

文献信息

• [EN] NOVEL M3 MUSCARINIC ACETYLCHOLINE RECEPTOR ANTAGONISTS<br/>[FR] NOUVEAUX ANTAGONISTES DU RECEPTEUR DE L'ACETYLCHOLINE MUSCARINIQUE M3
  申请人：GLAXO GROUP LTD

  公开号：WO2005087236A1

  公开（公告）日：2005-09-22

  Muscarinic Acetylcholine receptor antagonists and methods of using them are provided.

  提供了肌氢酸乙酰胆碱受体拮抗剂及其使用方法。
• 4-aminomethyl-pyridyl-2-oxy derivatives having anti-ulcer activity
  申请人：Fujirebio Kabushiki Kaisha

  公开号：US04912101A1

  公开（公告）日：1990-03-27

  A compound represented by the following formula or a salt thereof ##STR1## wherein each of R.sub.1 and R.sub.2 represents a lower alkyl group, or R.sub.1 and R.sub.2, together with the nitrogen atom to which they are bonded, may form a substituted or unsubstituted, saturated or partially unsaturated 4- to 8-membered heterocyclic group which may contain a hetero atom selected from N, O and S, Y represents a group of the formula --CH.sub.2 --CH.sub.2 -- or --CH.dbd.CH--, and n is 0, 1 or 2. This compound is useful as anti-peptic ulcer agent.

  以下式子所代表的化合物或其盐，其中R.sub.1和R.sub.2分别代表较低的烷基，或者R.sub.1和R.sub.2连同它们所结合的氮原子可以形成取代或未取代的饱和或部分不饱和的4-至8元杂环基团，该基团可以含有从N、O和S中选择的杂原子，Y代表公式-CH.sub.2-CH.sub.2-或-CH.dbd.CH-的基团，n为0、1或2。该化合物可用作抗消化性溃疡剂。
• Intermediates for pyridyloxy compounds having utility as anti-peptic
  申请人：Fujirebio Kabushiki Kaisha

  公开号：US04977267A1

  公开（公告）日：1990-12-11

  The compounds of the formulas (VI) and (VII) are useful intermediates in producing pyridyloxy derivatives of the formula (I), such as, for instance, N-4-[4-(piperidinomethyl)pyridyl-2-oxy]-2-butenyl}-2-(furfurylt hio)acetamide, which are useful as anti-peptic ulcer agents. The compounds of formula (VI) have the formula ##STR1## wherein A represents a formyl group, a protected formyl group, a hydroxymethyl group or a protected hydroxymethyl group. The compounds of formula (VIII) have the formula ##STR2## wherein G represents a formyl group, a protected formyl group, a hydroxymethyl group, a hydroxymethyl group in which the hydroxyl group is protected, or a halogenomethyl group, Y represents --CH.sub.2 --CH.sub.2 -- or --CH.dbd.CH--, and n is 0, 1 or 2.

  公式（VI）和（VII）的化合物是生产公式（I）的吡啶氧衍生物的有用中间体，例如，N-4-[4-(哌啶甲基)吡啶-2-氧基]-2-丁烯基}-2-(呋喃甲硫)乙酰胺，它们是有用的抗消化性溃疡药物。公式（VI）的化合物具有以下公式##STR1##其中A代表甲酰基，受保护的甲酰基，羟甲基或受保护的羟甲基。公式（VIII）的化合物具有以下公式##STR2##其中G代表甲酰基，受保护的甲酰基，羟甲基，受保护的羟甲基或卤代甲基，Y代表--CH.sub.2--CH.sub.2--或--CH.dbd.CH--，n为0、1或2。
• Novel compounds having 4-pyridylalkylthio group as substituent
  申请人：Honda Takahiro

  公开号：US20060194836A1

  公开（公告）日：2006-08-31

  A subject of the present invention is to provide a novel aromatic five- or six-memberd heterocyclic derivative having 4-pyridylalkylthio as a substituent or a salt thereof which is useful as a pharmaceutical. Compound represented by the following general formula [I] or salts thereof are useful as therapeutic agents for diseases in which angiogenesis or augmentation of vascular permeability is involved. In the formula, ring “A” is a benzene ring or an aromatic five- or six-memberd heterocycle which can be fused with a cycloalkane ring, “B” is alkylene, R 1 and R 2 , the same or different, are H, OH, substituted or unsubstituted alkoxy and the like, X and Y, the same or different, are group(s) selected from H, halogen, OH, substituted or unsubstituted alkoxy and the like respectively, p is 0, 1 or 2, and q is 0 or 1.

  本发明的目的是提供一种新的芳香性五元或六元杂环衍生物，其具有4-吡啶基烷硫基取代基或其盐，可作为药物使用。以下通式[I]所表示的化合物或其盐可用作治疗涉及血管生成或增强血管渗透性的疾病的治疗剂。其中，环“A”是苯环或芳香性五元或六元杂环，可以与环状烷基环融合，“B”是烷基，R1和R2，相同或不同，是H、OH、取代或未取代的烷氧基等，X和Y，相同或不同，分别是选择自H、卤素、OH、取代或未取代的烷氧基等的基团，p为0、1或2，q为0或1。
• Compounds having a 4-pyridylalkylthio group as a substituent
  申请人：Honda Takahiro

  公开号：US20090286786A1

  公开（公告）日：2009-11-19

  A compound having the following formula [I] or a pharmaceutically acceptable salt thereof: wherein A is benzene or an aromatic five-membered heterocycle which optionally is fused with a cycloalkane ring; B is an alkylene; R 1 and R 2 are hydrogen, hydroxy, alkoxy, aryloxy, alkyl, cycloalkyl, aryl, heterocycle, amino, alkylamino, arylamino or acyl, or R 1 and R 2 join together to form a heterocycle; X and Y are hydrogen, halogen, hydroxy, alkoxy, aryloxy, alkyl, cycloalkyl, aryl, mercapto, alkylthio, arylthio, carboxyl, an ester of carboxyl, an amide of carboxyl, cyano or nitro; p is 0, 1 or 2; and q is 0 or 1. The compound is useful for treating diseases in which angiogenesis or augmentation of vascular permeability is involved.

  一种具有以下式[I]或其药学上可接受的盐的化合物：其中，A是苯或一种芳香五元杂环，该芳香五元杂环可以选择性地与环烷环融合；B是一种烷基；R1和R2是氢、羟基、烷氧基、芳基氧基、烷基、环烷基、芳基、杂环、氨基、烷基氨基、芳基氨基或酰基，或R1和R2结合形成一个杂环；X和Y是氢、卤素、羟基、烷氧基、芳基氧基、烷基、环烷基、芳基、巯基、烷硫基、芳硫基、羧基、羧酸酯、羧酰胺、氰基或硝基；p为0、1或2；q为0或1。该化合物用于治疗与血管生成或血管通透性增加有关的疾病。