methyl-2-benzamido-methyl-3-hydroxybutyrate | 142248-11-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: methyl-2-benzamido-methyl-3-hydroxybutyrate
• 英文别名: Methyl 2-(benzamidomethyl)-3-hydroxybutanoate
• CAS: 142248-11-1
• 化学式: C₁₃H₁₇NO₄
• 分子量: 251.282
• InChiKey: ATBIFOORFZTUKF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  18
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  75.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  甲基2-[(苯甲酰基氨基)甲基]-3-氧代丁酸酯 在 sodium tetrahydroborate 作用下， 以 甲醇 为溶剂， 反应 2.0h， 以66.7%的产率得到methyl-2-benzamido-methyl-3-hydroxybutyrate
  参考文献：
  名称：

  Asymmetric synthesis of optically active methyl-2-benzamido-methyl-3-hydroxy-butyrate by robust short-chain alcohol dehydrogenases from Burkholderia gladioli

  摘要：

  特定的短链醇脱氢酶被发现并用于甲基2-苯甲酰胺基-3-羟基丁酸甲酯的动力学不对称转化，具有优异的立体选择性。

  DOI：

  10.1039/c5cc04652a

文献信息

• Ketoreductase Polypeptides for the Production of Azetidinone
  申请人：Campopiano Onorato

  公开号：US20090162909A1

  公开（公告）日：2009-06-25

  The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.

  本公开提供了经过改良的酮还原酶酶，其性能比自然存在的野生型酮还原酶酶有所提高。还提供了编码经过改良的酮还原酶酶的多核苷酸，能够表达经过改良的酮还原酶酶的宿主细胞，以及使用经过改良的酮还原酶酶合成各种手性化合物的方法。
• Ketoreductase polypeptides for the production of azetidinone
  申请人：Codexis, Inc.

  公开号：US09382519B2

  公开（公告）日：2016-07-05

  The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.

  本公开提供了经过工程改造的酮还原酶酶，其性能比自然存在的野生型酮还原酶酶有所改进。同时还提供了编码经过工程改造的酮还原酶酶的多核苷酸，能够表达经过工程改造的酮还原酶酶的宿主细胞，以及使用经过工程改造的酮还原酶酶合成各种手性化合物的方法。
• 2,2'-bis(diphenylphosphino)-5,5',6,6',7,7',8,8'-octahydro-1
  申请人：Takasago International Corporation

  公开号：US05206399A1

  公开（公告）日：1993-04-27

  2,2'-Bis(diphenylphosphino)-5,5',6,6',7,7',8,8'-octahydro-1,1'-binaphthyl represented by formula (I). ##STR1## is disclosed. A transition metal complex containing the same, a process for producing 2,2'-Bis(diphenylphosphino)-5,5',6,6',7,7',8,8'-octahydro-1,1'-binaphthyl, and a process for producing 2,2'-bis(diphenylphosphinyl)-5,5',6,6',7,7',8,8'-octahydro-1,1'-binaphthyl are also disclosed.

  公开了化学式为(I)的2,2'-双(二苯基膦基)-5,5',6,6',7,7',8,8'-八氢-1,1'-联萘。同时还公开了含有该化合物的过渡金属配合物，制备2,2'-双(二苯基膦基)-5,5',6,6',7,7',8,8'-八氢-1,1'-联萘的方法以及制备2,2'-双(二苯基膦氧基)-5,5',6,6',7,7',8,8'-八氢-1,1'-联萘的方法。
• KETOREDUCTASE POLYPEPTIDES FOR THE PRODUCTION OF AZETIDINONE
  申请人：Campopiano Onorato

  公开号：US20110159567A1

  公开（公告）日：2011-06-30

  The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.

  本公开提供了经过改良的酮还原酶酶，其性质比自然存在的野生型酮还原酶酶更好。同时提供编码改良酮还原酶酶的多核苷酸，能够表达改良酮还原酶酶的宿主细胞，以及使用改良酮还原酶酶合成各种手性化合物的方法。
• Design and Synthesis of Diphosphine Ligands Based on the Chiral Biindolyl Scaffold and Their Application in Transition-Metal Catalysis
  作者：Fuhao Zhang、Gen-Qiang Chen、Xumu Zhang

  DOI：10.1021/acs.orglett.3c03068

  日期：2024.3.1

  easy access to a range of bisphosphine ligands (decagram scale, up to 58% total yield, only three steps). The synthetic method is characterized by an efficient central-to-axial chirality transfer strategy. In particular, the superior performance of the ligands has been demonstrated in diverse reactions, including several asymmetric hydrogenations, asymmetric conjugate reductions, and cycloisomerization

  基于 2,2'-联吲哚基和市售手性结构单元，开发了一种极其简洁、可扩展和立体选择性合成的特殊手性骨架。这种新颖的骨架可以轻松获得一系列双膦配体（十克规模，总产率高达 58%，只需三个步骤）。该合成方法的特点是有效的中心到轴手性转移策略。特别是，配体的优异性能已在多种反应中得到证明，包括几种不对称氢化、不对称共轭还原和环异构化反应，表明新开发的手性骨架在进一步修饰和探索新型手性化合物方面具有巨大的应用潜力。配体和催化剂。