1-(2,5-二甲氧基苯基)-2-甲基丙烯 | 35205-30-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 1-(2,5-二甲氧基苯基)-2-甲基丙烯
• 英文名称: 1-(2,5-dimethoxyphenyl)-2-methylpropene
• 英文别名: 1,4-dimethoxy-2-(2-methylprop-1-enyl)benzene
• CAS: 35205-30-2
• 化学式: C₁₂H₁₆O₂
• 分子量: 192.258
• InChiKey: RBCAKMBIDPHFIU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-(2,5-二甲氧基苯基)-2-甲基丙烯 在 5%-palladium/activated carbon 、 氢气 作用下， 生成 1,4-二甲氧基-2-(2-甲基丙基)苯
  参考文献：
  名称：

  COMPOUNDS AND METHODS FOR TREATING INFLAMMATORY DISORDERS

  摘要：

  本发明涉及具有抗炎性质的化合物和制药组合物。同时提供了使用本发明中的化合物或组合物治疗需要的主题的炎症性疾病的方法。

  公开号：

  US20220119340A1
• 作为产物：
  描述：

  1-(2,5-dimethoxyphenyl)-2-methylpropan-1-one 在 sodium tetrahydroborate 、 乙醇 作用下， 以 苯 为溶剂， 生成 1-(2,5-二甲氧基苯基)-2-甲基丙烯
  参考文献：
  名称：

  염증성 장애를 치료하기 위한 화합물 및 방법

  摘要：

  本发明涉及具有抗炎特性的化合物和药学组合物。此外，本发明提供了使用该化合物或组合物治疗需要治疗炎症障碍的对象的方法。

  公开号：

  KR20220008264A

文献信息

• 염증성 장애를 치료하기 위한 화합물 및 방법
  申请人：보드 오브 슈퍼바이저스 오브 루이지애나 스테이트 유니버시티 앤드 애그리컬추얼 앤드 메카니컬 컬리지

  公开号：KR20220008264A

  公开（公告）日：2022-01-20

  본 발명은 항-염증성 특성을 갖는 화합물 및 약학 조성물을 특징으로 한다. 또한, 치료를 필요로 하는 대상에서 염증성 장애를 치료하기 위한 본 발명의 화합물 또는 조성물을 사용하는 방법을 제공한다.

  本发明涉及具有抗炎特性的化合物和药学组合物。此外，本发明提供了使用该化合物或组合物治疗需要治疗炎症障碍的对象的方法。
• COMPOUNDS AND METHODS FOR TREATING INFLAMMATORY DISORDERS
  申请人：Board of Supervisors of Louisiana State University and Agricultural and Mechanical College

  公开号：US20220119340A1

  公开（公告）日：2022-04-21

  The invention features compounds and pharmaceutical compositions having anti-inflammatory properties. Also provided are methods of using the compounds or compositions of the invention for treating an inflammatory disorder in a subject in need thereof.

  本发明涉及具有抗炎性质的化合物和制药组合物。同时提供了使用本发明中的化合物或组合物治疗需要的主题的炎症性疾病的方法。
• Anti-Bacterial Compounds
  申请人：Parker Jane Katy

  公开号：US20080096894A1

  公开（公告）日：2008-04-24

  Compounds of formula (I), or salts or solvates thereof, in vitro as inhibitors of growth of Gram-positive bacteria, where A is selected from formula (a).
• SELECTIVE SALMONELLA OR E. COLI CULTIVATION METHOD, COMPOSITIONS AND USES
  申请人：SOLUS SCIENTIFIC SOLUTIONS LTD

  公开号：US20220002663A1

  公开（公告）日：2022-01-06

  The present disclosure provides rapid, convenient and sensitive means to detect low abundance target Gram negative bacteria such as Salmonella contamination from a range of samples, including food samples and environmental samples, through a single-step culture method and downstream sensitive detection.
• Substituent branching in phenethylamine-type hallucinogens: a comparison of 1-[2,5-dimethoxy-4-(2-butyl)phenyl]-2-aminopropane and 1-[2,5-dimethoxy-4-(2-methylpropyl)phenyl]-2-aminopropane
  作者：Robert A. Oberlender、Paresh J. Kothari、David E. Nichols、Joseph E. Zabik

  DOI：10.1021/jm00372a015

  日期：1984.6

  Two novel hallucinogen analogues related to 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM, STP) were synthesized and evaluated in the two-lever drug discrimination paradigm by using 0.08 mg/kg of LSD as the training drug stimulus. The two compounds differ from each other only with respect to the point of branching in the 4-alkyl group. However, pharmacological evaluation revealed a clear difference in difference in potency and degree of LSD generalization for the two isomers. Branching adjacent to the ring, as in the 4-(2-butyl) analogue, may provide steric interference to the formation of the drug-receptor complex, while branching one methylene unit removed from the ring, as in the 4-(2-methylpropyl) analogue, poses less of a steric problem for the drug-receptor interaction. This is consistent with the idea that formation of a charge-transfer complex between the hallucinogen molecule and the receptor may be one of the features of this drug-receptor interaction.