methyl α-D-mannoseptanoside | 1117805-71-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧杂环己烷
• 英文名称: methyl α-D-mannoseptanoside
• 英文别名: (2S,3S,4S,5R,6R)-2-methoxyoxepane-3,4,5,6-tetrol
• CAS: 1117805-71-6
• 化学式: C₇H₁₄O₆
• 分子量: 194.185
• InChiKey: OZKYFFZPEZYATK-VEIUFWFVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.6
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  99.4
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  methyl α-D-mannoseptanoside 、 乙酸酐 在 4-二甲氨基吡啶 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 以136 mg的产率得到(2S,3S,4S,5R,6R)-2-methoxyoxepane-3,4,5,6-tetrayl tetraacetate
  参考文献：
  名称：

  1,5-α-d-Mannoseptanosides, Ring-Size Isomers That Are Impervious to α-Mannosidase-Catalyzed Hydrolysis

  摘要：

  1,5-D-Mannoseptanosyl di- and trisaccharide ring-size isomers of the corresponding mannopyranosyl oligosaccharides have been prepared. Remarkably, these compounds show no inhibition of the alpha-mannosidase-catalyzed hydrolysis of p-nitrophenyl-alpha-D-mannopyranoside.

  DOI：

  10.1021/ol8028065
• 作为产物：
  描述：

  (3R,4R,5S,6S,7S)-4,5,6-tris(benzyloxy)-7-methoxyoxepan-3-ol 在 10% Pd(OH)2/C 、 氢气 作用下， 以 乙醇 、 乙酸乙酯 为溶剂， 反应 2.5h， 生成 methyl α-D-mannoseptanoside
  参考文献：
  名称：

  1,5-α-d-Mannoseptanosides, Ring-Size Isomers That Are Impervious to α-Mannosidase-Catalyzed Hydrolysis

  摘要：

  1,5-D-Mannoseptanosyl di- and trisaccharide ring-size isomers of the corresponding mannopyranosyl oligosaccharides have been prepared. Remarkably, these compounds show no inhibition of the alpha-mannosidase-catalyzed hydrolysis of p-nitrophenyl-alpha-D-mannopyranoside.

  DOI：

  10.1021/ol8028065
• 作为试剂：
  描述：

  对硝基苯-Alpha-D-吡喃甘露糖苷 在 Jack bean α-mannosidase 、 methyl α-D-mannoseptanoside 作用下， 反应 0.33h， 生成 4-硝基苯酚阴离子
  参考文献：
  名称：

  1,5-α-d-Mannoseptanosides, Ring-Size Isomers That Are Impervious to α-Mannosidase-Catalyzed Hydrolysis

  摘要：

  1,5-D-Mannoseptanosyl di- and trisaccharide ring-size isomers of the corresponding mannopyranosyl oligosaccharides have been prepared. Remarkably, these compounds show no inhibition of the alpha-mannosidase-catalyzed hydrolysis of p-nitrophenyl-alpha-D-mannopyranoside.

  DOI：

  10.1021/ol8028065

文献信息

• COMPOUNDS, INTERMEDIATES, AND METHODS OF PREPARING THE SAME
  申请人：Boone Matthew A.

  公开号：US20110275839A1

  公开（公告）日：2011-11-10

  The present disclosure provides optionally substituted seven-membered ring isomers of naturally occurring carbohydrate compounds, methods of synthesizing these compounds, intermediate compounds, methods of synthesizing the intermediate compounds, and the like.

  本文披露了天然糖类化合物的可选取代的七元环异构体，合成这些化合物的方法，中间体化合物，合成中间体化合物的方法等。
• [EN] COMPOUNDS, INTERMEDIATES, AND METHODS OF PREPARING THE SAME<br/>[FR] COMPOSÉS, INTERMÉDIAIRES ET LEURS PROCÉDÉS DE PRÉPARATION
  申请人：UNIV EMORY

  公开号：WO2010078396A3

  公开（公告）日：2010-10-28
• 1,5-α-<scp>d</scp>-Mannoseptanosides, Ring-Size Isomers That Are Impervious to α-Mannosidase-Catalyzed Hydrolysis
  作者：Matthew A. Boone、Frank E. McDonald、Joseph Lichter、Stefan Lutz、Rui Cao、Kenneth I. Hardcastle

  DOI：10.1021/ol8028065

  日期：2009.2.19

  1,5-D-Mannoseptanosyl di- and trisaccharide ring-size isomers of the corresponding mannopyranosyl oligosaccharides have been prepared. Remarkably, these compounds show no inhibition of the alpha-mannosidase-catalyzed hydrolysis of p-nitrophenyl-alpha-D-mannopyranoside.