5-methoxycarbonylpyrido<2,3-d>pyrimidine-2,4,7(1H,3H,8H)-trione | 57821-16-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶并嘧啶类
• 英文名称: 5-methoxycarbonylpyrido<2,3-d>pyrimidine-2,4,7(1H,3H,8H)-trione
• 英文别名: methyl 2,4,7-trioxo-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidine-5-carboxylate；2,4,7-trioxo-1,2,3,4,7,8-hexahydro-pyrido[2,3-d]pyrimidine-5-carboxylic acid methyl ester；methyl 2,4,7-trioxo-1,8-dihydropyrido[2,3-d]pyrimidine-5-carboxylate
• CAS: 57821-16-6
• 化学式: C₉H₇N₃O₅
• 分子量: 237.172
• InChiKey: RECBNRMVZIKEPN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.8
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  114
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  5-methoxycarbonylpyrido<2,3-d>pyrimidine-2,4,7(1H,3H,8H)-trione 在 一水合肼 作用下， 以 乙醇 为溶剂， 反应 30.0h， 生成 N'-chloroacetyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidine-5-carbohydrazide
  参考文献：
  名称：

  Synthesis and antitumor activity of new pyrido[2,3-d]pyrimidine derivatives

  摘要：

  New series of pyrido[2,3-d]pyrimidines such as; 5-(4-aryl-5-sulfanyl-4H-[1,2,4]triazol-3-yl) 1H,3H,8H-pyrido[2,3-d]pyrimidine-2,4,7-triones 6, 7; S-[3-(2,4,7-trioxo-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidin-5-yl)-4-(4-substituted phenyl)-4H-[1,2,4]triazol-5-yl]-2-(4-phenylpiperazin-1-yl)ethanethioates 10, 11; 2,4,7-trioxo-N'-[(4-substituted piperazin-1-yl)acetyl]-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidine-5-carbohydrazides 13-16 and N'-arylidene-2,4,7-trioxo-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidine-5-carbohydrazides 17-19 was synthesized through the reaction of the key intermediate 2,4,7-trioxo-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidine-5-carbohydrazide 3 with different reagents. The structures of the newly synthesized compounds were elucidated through microanalysis, IR, H-1 NMR, C-13 NMR, and mass spectroscopy. These compounds have been subjected to in vitro antitumor evaluation by bleomycin-dependant DNA damage assay. The most active antitumor compound 6 was selected for further in vivo evaluation of antineoplastic activity against Ehrlich ascites carcinoma in mice. It was observed that our target compound has a potent antitumor activity.

  DOI：

  10.1007/s00044-012-0396-0
• 作为产物：
  描述：

  4-氨基-2,6-二羟基嘧啶 、 丁炔二酸二甲酯 以 水 为溶剂， 反应 4.0h， 以38%的产率得到5-methoxycarbonylpyrido<2,3-d>pyrimidine-2,4,7(1H,3H,8H)-trione
  参考文献：
  名称：

  Al-Hassan, Saieba S.; Kulick, Russell J.; Livingstone, Daniel B., Journal of the Chemical Society. Perkin transactions I, 1980, p. 2645 - 2656

  摘要：

  DOI：

文献信息

• Al-Hassan, Saieba S.; Kulick, Russell J.; Livingstone, Daniel B., Journal of the Chemical Society. Perkin transactions I, 1980, p. 2645 - 2656
  作者：Al-Hassan, Saieba S.、Kulick, Russell J.、Livingstone, Daniel B.、Suckling, Colin J.、Wood, Hamish C. S.、Wrigglesworth, Roger、Ferone, Robert

  DOI：——

  日期：——
• ANDERSON G. L.; SHIM J. L.; BROOM A. D., J. ORG. CHEM. <JOCE-AH>, 1977, 42, NO 6, 993-996
  作者：ANDERSON G. L.、 SHIM J. L.、 BROOM A. D.

  DOI：——

  日期：——
• Synthesis and antitumor activity of new pyrido[2,3-d]pyrimidine derivatives
  作者：Magdy M. Gineinah、Magda N. A. Nasr、Sahar M. I. Badr、Walaa M. El-Husseiny

  DOI：10.1007/s00044-012-0396-0

  日期：2013.8

  New series of pyrido[2,3-d]pyrimidines such as; 5-(4-aryl-5-sulfanyl-4H-[1,2,4]triazol-3-yl) 1H,3H,8H-pyrido[2,3-d]pyrimidine-2,4,7-triones 6, 7; S-[3-(2,4,7-trioxo-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidin-5-yl)-4-(4-substituted phenyl)-4H-[1,2,4]triazol-5-yl]-2-(4-phenylpiperazin-1-yl)ethanethioates 10, 11; 2,4,7-trioxo-N'-[(4-substituted piperazin-1-yl)acetyl]-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidine-5-carbohydrazides 13-16 and N'-arylidene-2,4,7-trioxo-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidine-5-carbohydrazides 17-19 was synthesized through the reaction of the key intermediate 2,4,7-trioxo-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidine-5-carbohydrazide 3 with different reagents. The structures of the newly synthesized compounds were elucidated through microanalysis, IR, H-1 NMR, C-13 NMR, and mass spectroscopy. These compounds have been subjected to in vitro antitumor evaluation by bleomycin-dependant DNA damage assay. The most active antitumor compound 6 was selected for further in vivo evaluation of antineoplastic activity against Ehrlich ascites carcinoma in mice. It was observed that our target compound has a potent antitumor activity.