fluorenone-3,6-dicarboxylic acid | 85313-20-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: fluorenone-3,6-dicarboxylic acid
• 英文别名: 9-oxo-9H-fluorene-3,6-dicarboxylic acid；9-Oxofluorene-3,6-dicarboxylic acid
• CAS: 85313-20-8
• 化学式: C₁₅H₈O₅
• 分子量: 268.226
• InChiKey: NWDSCSXYLSCZAY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  91.7
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  fluorenone-3,6-dicarboxylic acid 在 苯膦酰二氯 作用下， 以 二甲基亚砜 为溶剂， 反应 14.0h， 生成 (3,6-bisethoxycarbonyl-9H-fluoren-9-ylidene)propanedinitrile
  参考文献：
  名称：

  Sbrana, Giuseppe; Scotton, Mirella; Angeloni, Leonardo, Journal of the Chemical Society. Perkin transactions II, 1982, p. 1611 - 1614

  摘要：

  DOI：
• 作为产物：
  描述：

  3,6-dimethyl-9H-fluoren-9-one 在 sodium dichromate 作用下， 以 水 为溶剂， 250.0 ℃ 、4.26 MPa 条件下， 反应 12.0h， 以88%的产率得到fluorenone-3,6-dicarboxylic acid
  参考文献：
  名称：

  Sbrana, Giuseppe; Scotton, Mirella; Angeloni, Leonardo, Journal of the Chemical Society. Perkin transactions II, 1982, p. 1611 - 1614

  摘要：

  DOI：

文献信息

• The Synthesis of Some Head to Head Linked DNA Minor Groove Binders
  作者：Abedawn I. Khalaf、Andrew R. Pitt、Martin Scobie、Colin J. Suckling、John Urwin、Roger D. Waigh、Robert V. Fishleigh、Steven C. Young、William A. Wylie

  DOI：10.1016/s0040-4020(00)00432-4

  日期：2000.7

  A series of head to head linked dimers of heterocyclic amino acids has been prepared for investigation of affinity and selectivity in binding to the minor groove of DNA. The selection of targets for synthesis was led by computer based design. Several novel dicarboxylic acid linkers including indoles, phenanthrenes, a fluorenone, and a bisbenzothiophene have been included. Analysis of binding to DNA

  已经制备了一系列首尾相连的杂环氨基酸二聚体，用于研究与DNA小沟结合的亲和力和选择性。合成目标的选择由基于计算机的设计主导。已经包括几种新颖的二羧酸连接基，包括吲哚，菲，芴酮和双苯并噻吩。通过印迹分析与DNA的结合表明对衍生自2,7-二氢菲二羧酸的化合物具有很高的亲和力，并且对包含至少4个AT对的AT富集区域具有主要选择性，但具有跨越两个CG碱基对的能力。
• PROCESS FOR PRODUCTION OF HIGH-PURITY BIS-BETA-HYDROXYETHYL TEREPHTHALATE
  申请人：Aies Co., Ltd.

  公开号：EP1254888A1

  公开（公告）日：2002-11-06

  To provide a process for producing a high-purity bis-β-hydroxyethyl terephthalate from crude terephthalic acid. A process for producing high-purity bis-β-hydroxyethyl terephthalate by carrying out the following steps (1) to (4) in the mentioned order: (1) the step of esterifying crude terephthalic acid with ethylene glycol and/or ethylene oxide to form a reaction product containing bis-β-hydroxyethyl terephthalate, (2) the step of preparing a solution containing bis-(3-hydroxyethyl terephthalate as the main solute and ethylene glycol as the main solvent by mixing the above reaction product obtained in the above step (1) with ethylene glycol as required and deionizing the solution to form a deionized solution of bis-β-hydroxyethyl terephthalate, (3) the step of distilling off substances having a boiling point lower than that of bis-β-hydroxyethyl terephthalate from the above deionized solution obtained in the step (2) to form crude bis-β-hydroxyethyl terephthalate, and (4) the step of subjecting the crude bis-β-hydroxyethyl terephthalate obtained in the step (3) to molecular distillation to distill out bis-β-hydroxyethyl terephthalate.

  提供一种利用粗对苯二甲酸生产高纯度对苯二甲酸双-β-羟乙基酯的工艺。 一种生产高纯度对苯二甲酸双-β-羟乙基酯的工艺，按上述顺序进行以下步骤（1）至（4）：(1) 将粗对苯二甲酸与乙二醇和/或环氧乙烷酯化，形成含有对苯二甲酸双-β-羟乙基酯的反应产物、(2) 将上述步骤(1)中获得的上述反应产物按要求与乙二醇混合，并将溶液去离子，形成对苯二甲酸二-β-羟乙基酯的去离子溶液，制备以对苯二甲酸二-(3-羟乙基)酯为主要溶质、以乙二醇为主要溶剂的溶液、(3) 从上述步骤(2)得到的去离子溶液中蒸馏出沸点低于对苯二甲酸双-β-羟乙基酯沸点的物质，形成对苯二甲酸双-β-羟乙基酯粗品，以及 (4) 将步骤(3)得到的对苯二甲酸双-β-羟乙基酯粗品进行分子蒸馏，蒸馏出对苯二甲酸双-β-羟乙基酯。
• Process for production of high-purity bis-beta-hydroxyethyl terephthalate
  申请人：——

  公开号：US20030050499A1

  公开（公告）日：2003-03-13

  To provide a process for producing a high-purity bis-&bgr;-hydroxyethyl terephthalate from crude terephthalic acid. A process for producing high-purity bis-&bgr;-hydroxyethyl terephthalate by carrying out the following steps (1) to (4) in the mentioned order: (1) the step of esterifying crude terephthalic acid with ethylene glycol and/or ethylene oxide to form a reaction product containing bis-&bgr;-hydroxyethyl terephthalate, (2) the step of preparing a solution containing bis-&bgr;-hydroxyethyl terephthalate as the main solute and ethylene glycol as the main solvent by mixing the above reaction product obtained in the above step (1) with ethylene glycol as required and deionizing the solution to form a deionized solution of bis-&bgr;-hydroxyethyl terephthalate, (3) the step of distilling off substances having a boiling point lower than that of bisM-&bgr;-hydroxyethyl terephthalate from the above deionized solution obtained in the step (2) to form crude bis-&bgr;-hydroxyethyl terephthalate, and (4) the step of subjecting the crude bis-&bgr;-hydroxyethyl terephthalate obtained in the step (3) to molecular distillation to distill out bis-&bgr;-hydroxyethyl terephthalate.

  提供一种利用粗对苯二甲酸生产高纯度对苯二甲酸双&bgr;-羟乙基酯的工艺。 一种生产高纯度对苯二甲酸双&bgr;-羟乙基酯的工艺，按上述顺序进行以下步骤（1）至（4）：(1)将粗对苯二甲酸与乙二醇和/或环氧乙烷酯化以形成含有对苯二甲酸双-&bgr;-羟乙基酯的反应产物的步骤，(2)制备含有对苯二甲酸双-&bgr;-羟乙基酯的溶液的步骤；-对苯二甲酸羟乙酯作为主溶质和乙二醇作为主溶剂的溶液的制备步骤，将上述步骤(1)中得到的上述反应产物按要求与乙二醇混合，并将溶液去离子，形成双-&bgr;-对苯二甲酸羟乙酯的去离子溶液；-对苯二甲酸二乙酯的去离子溶液，(3) 从上述步骤(2)得到的去离子溶液中蒸馏出沸点低于对苯二甲酸二乙酯沸点的物质，形成粗对苯二甲酸二乙酯；-和 (4) 将步骤 (3) 中获得的粗对苯二甲酸双 M&bgr; - 羟乙基酯进行分子蒸馏，以蒸馏出对苯二甲酸双 M&bgr; - 羟乙基酯。
• SBRANA, G.;SCOTTON, M.;ANGELONI, L., J. CHEM. SOC. PERKIN TRANS., 1982, N 12, 1611-1614
  作者：SBRANA, G.、SCOTTON, M.、ANGELONI, L.

  DOI：——

  日期：——
• US6710202B2
  申请人：——

  公开号：US6710202B2

  公开（公告）日：2004-03-23