[1-Pyridin-4-yl-meth-(Z)-ylidene]-thiazol-2-yl-amine | 327991-24-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: [1-Pyridin-4-yl-meth-(Z)-ylidene]-thiazol-2-yl-amine
• 英文别名: 1-pyridin-4-yl-N-(1,3-thiazol-2-yl)methanimine
• CAS: 327991-24-2
• 化学式: C₉H₇N₃S
• 分子量: 189.241
• InChiKey: UFSGQCLHAAHWKA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  66.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  [1-Pyridin-4-yl-meth-(Z)-ylidene]-thiazol-2-yl-amine 在 sodium tetrahydroborate 作用下， 以 甲醇 为溶剂， 生成 吡啶-4-基甲基-噻唑-2-基-胺
  参考文献：
  名称：

  Heteroaryl substituted bis-trifluoromethyl carbinols as malonyl-CoA decarboxylase inhibitors

  摘要：

  A series of heteroaryl-substituted bis-trifluoromethyl carbinols were prepared and evaluated as malonyl-CoA decarboxylase (MCD) inhibitors. Some thiazole-based derivatives showed potent in vitro MCD inhibitory activities and significantly increased glucose oxidation rates in isolated working rat hearts. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.03.100
• 作为产物：
  描述：

  4-吡啶甲醛 、 2-氨基噻唑 以 甲苯 为溶剂， 生成 [1-Pyridin-4-yl-meth-(Z)-ylidene]-thiazol-2-yl-amine
  参考文献：
  名称：

  Heteroaryl substituted bis-trifluoromethyl carbinols as malonyl-CoA decarboxylase inhibitors

  摘要：

  A series of heteroaryl-substituted bis-trifluoromethyl carbinols were prepared and evaluated as malonyl-CoA decarboxylase (MCD) inhibitors. Some thiazole-based derivatives showed potent in vitro MCD inhibitory activities and significantly increased glucose oxidation rates in isolated working rat hearts. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.03.100

文献信息

• Heteroaryl substituted bis-trifluoromethyl carbinols as malonyl-CoA decarboxylase inhibitors
  作者：Jie-Fei Cheng、Chi Ching Mak、Yujin Huang、Richard Penuliar、Masahiro Nishimoto、Lin Zhang、Mi Chen、David Wallace、Thomas Arrhenius、Donald Chu、Guang Yang、Miguel Barbosa、Rick Barr、Jason R.B. Dyck、Gary D. Lopaschuk、Alex M. Nadzan

  DOI：10.1016/j.bmcl.2006.03.100

  日期：2006.7

  A series of heteroaryl-substituted bis-trifluoromethyl carbinols were prepared and evaluated as malonyl-CoA decarboxylase (MCD) inhibitors. Some thiazole-based derivatives showed potent in vitro MCD inhibitory activities and significantly increased glucose oxidation rates in isolated working rat hearts. (c) 2006 Elsevier Ltd. All rights reserved.