Cambridge id 5261958

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Cambridge id 5261958
• 英文别名: N-[4-[[4-(thiophene-2-carbonylamino)phenyl]carbamoyl]phenyl]thiophene-2-carboxamide
• 化学式: C₂₃H₁₇N₃O₃S₂
• 分子量: 447.538
• InChiKey: HQDPMSRLNTYROL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  31
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  144
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-噻吩甲酸 在 氯化亚砜 作用下， 以 二氯甲烷 为溶剂， 反应 7.0h， 生成 Cambridge id 5261958
  参考文献：
  名称：

  Synthesis and antifungal activity evaluation of new heterocycle containing amide derivatives

  摘要：

  A series of heterocycle containing amide derivatives (1-28) were synthesised by the combination of acyl chlorides (1a, 2a) and heterocyclic/homocyclic ring containing amines, and their in vitro antifungal activity was evaluated against five plant pathogenic fungi, namely Gibberella zeae, Helminthosporium maydis, Rhizoctonia solani, Botrytis cinerea and Sclerotinia sclerotiorum. Results of antifungal activity analysis indicated that some of the products showed good to excellent antifungal activity, as compound 2 showed excellent activity against G. zeae and R. solani and potent activity against H. maydi, B. cinerea and S. sclerotiorum, and compounds 1, 8 and 10 also displayed excellent antifungal potential against H. maydi, B. cinerea and S. sclerotiorum and good activity against R. solani when compared with the standard carbendazim.

  DOI：

  10.1080/14786419.2015.1041137

文献信息

• 甲酰氨基二苯基酰胺类化合物及其应用
  申请人：西华大学

  公开号：CN104610204B

  公开（公告）日：2016-08-24

  本发明公开了一种甲酰氨基二苯基酰胺类化合物及其应用，涉及农用杀菌剂领域。该化合物结构如通式(I)所示，(I)，式中，X为氧原子、硫原子；R为氢原子、卤素原子、C1‑C4的烷基或烷氧基。该化合物结构简单，对小麦赤霉病菌和玉米小斑病菌等多种植物病原真菌具有较好的抑制活性，可以用于防治植物病原真菌，是其在农药领域的新用途。
• Synthesis and antifungal activity evaluation of new heterocycle containing amide derivatives
  作者：Xuesong Wang、Sumei Gao、Jian Yang、Yang Gao、Ling Wang、Xiaorong Tang

  DOI：10.1080/14786419.2015.1041137

  日期：2016.3.18

  A series of heterocycle containing amide derivatives (1-28) were synthesised by the combination of acyl chlorides (1a, 2a) and heterocyclic/homocyclic ring containing amines, and their in vitro antifungal activity was evaluated against five plant pathogenic fungi, namely Gibberella zeae, Helminthosporium maydis, Rhizoctonia solani, Botrytis cinerea and Sclerotinia sclerotiorum. Results of antifungal activity analysis indicated that some of the products showed good to excellent antifungal activity, as compound 2 showed excellent activity against G. zeae and R. solani and potent activity against H. maydi, B. cinerea and S. sclerotiorum, and compounds 1, 8 and 10 also displayed excellent antifungal potential against H. maydi, B. cinerea and S. sclerotiorum and good activity against R. solani when compared with the standard carbendazim.