4-methyl-2-morpholino-2-cyanopentane | 1157263-92-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: 4-methyl-2-morpholino-2-cyanopentane
• 英文别名: 2,4-dimethyl-2-morpholin-4-ylpentanenitrile
• CAS: 1157263-92-7
• 化学式: C₁₁H₂₀N₂O
• 分子量: 196.293
• InChiKey: UIJDVZRLEVSLMF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  36.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-methyl-2-(morpholin-4-yl)propionitrile 、 4-甲基-2-戊酮 在 potassium carbonate 作用下， 以65%的产率得到4-methyl-2-morpholino-2-cyanopentane
  参考文献：
  名称：

  One-stage synthesis of adamantyl-containing α-aminonitriles

  摘要：

  Reactions of 2-adamantan-2-one, acetone cyanohydrin, and amine lead to the formation of substituted 2-amino-2-cyanoadamantanes. The reaction is of a general character as has been proved by examples on a series of ketones and amines and it proceeds through the formation from the acetone cyanohydrin and amines of 2-amino-2-cyanopropane derivatives reacting further with the carbonyl compounds.

  DOI：

  10.1134/s107042801308006x

文献信息

• One-stage synthesis of adamantyl-containing α-aminonitriles
  作者：Yu. V. Popov、V. M. Mokhov、N. A. Tankabekyan

  DOI：10.1134/s107042801308006x

  日期：2013.8

  Reactions of 2-adamantan-2-one, acetone cyanohydrin, and amine lead to the formation of substituted 2-amino-2-cyanoadamantanes. The reaction is of a general character as has been proved by examples on a series of ketones and amines and it proceeds through the formation from the acetone cyanohydrin and amines of 2-amino-2-cyanopropane derivatives reacting further with the carbonyl compounds.