2,7-dibromo-9,9-bis(6'-(tert-butoxycarbonylamino)hexyl)fluorene | 918865-61-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: 2,7-dibromo-9,9-bis(6'-(tert-butoxycarbonylamino)hexyl)fluorene
• 英文别名: tert-butyl N-[6-[2,7-dibromo-9-[6-[(2-methylpropan-2-yl)oxycarbonylamino]hexyl]fluoren-9-yl]hexyl]carbamate
• CAS: 918865-61-9
• 化学式: C₃₅H₅₀Br₂N₂O₄
• 分子量: 722.601
• InChiKey: UKMBGZNJFQCFNP-UHFFFAOYSA-N

物化性质

• 沸点：
  733.3±50.0 °C(Predicted)
• 密度：
  1.254±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  10.8
• 重原子数：
  43
• 可旋转键数：
  18
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  76.7
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2,7-dibromo-9,9-bis(6'-(tert-butoxycarbonylamino)hexyl)fluorene 在 硼酸 、 三氟乙酸 作用下， 以 甲醇 、 二氯甲烷 、 水 为溶剂， 反应 24.0h， 生成
  参考文献：
  名称：

  CN116920090

  摘要：

  公开号：
• 作为产物：
  描述：

  1,6-二溴己烷 在 sodium azide 、 四丁基溴化铵 、 三苯基膦 、 potassium hydroxide 作用下， 以 四氢呋喃 、 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 4.83h， 生成 2,7-dibromo-9,9-bis(6'-(tert-butoxycarbonylamino)hexyl)fluorene
  参考文献：
  名称：

  CN116920090

  摘要：

  公开号：

文献信息

• Lipid-modified conjugated polymernanoparticles for cell imaging and transfection
  作者：Xuli Feng、Yanli Tang、Xinrui Duan、Libing Liu、Shu Wang

  DOI：10.1039/b915112e

  日期：——

  A new fluorescent nanoparticle based on lipid-modified cationic poly(fluorenylene phenylene) (PFPL) was prepared and characterized. The PFPL is amphiphilic and has two unique structural features. First, the lipid is designed as a side chain in consideration of the fact that the lipid is biocompatible and can enter the cytoplasm easily and also provides protective layers to conjugated polymer backbones. Second, the ammonium pendant groups can interface with genes that offer PFPL as a vector for gene delivery. The PFPL forms uniform nanoparticles in water with a size of about 50 nm. The PFPL nanoparticle exhibits excellent photostability and little cytotoxicity. It can easily enter the cytoplasm via endocytosis (within 4 hours) and can be used for cell imaging. Furthermore, the PFPL particle can successfully deliver plasmids (pCX-EGFP) into lung cancer cells (A549) for transcription and translation. Thus, one can directly track the entrance of plasmids into cells and the expression of GFP proteins using fluorescence microscopy. The PFPL nanoparticle is a good candidate for cell imaging and tracking important intracellular processes in future research.

  我们制备了一种基于脂质修饰阳离子聚（芴苯基）的新型荧光纳米粒子（PFPL），并对其进行了表征。PFPL是两亲性的，具有两个独特的结构特征。首先，考虑到脂质具有生物相容性，可以轻松进入细胞质，并且还可以为共轭聚合物骨架提供保护层，因此脂质被设计为侧链。其次，铵基团可以与基因相互作用，从而将PFPL作为基因传递的载体。PFPL在水中形成大小约为50 nm的均匀纳米粒子。PFPL纳米粒子具有优异的光稳定性和低细胞毒性。它可以通过内吞作用（4小时内）轻松进入细胞质，可用于细胞成像。此外，PFPL粒子可以成功地将质粒（pCX-EGFP）传递到肺癌细胞（A549）中进行转录和翻译。因此，人们可以使用荧光显微镜直接追踪质粒进入细胞的过程以及GFP蛋白的表达。PFPL纳米粒子是细胞成像和追踪未来研究中重要的细胞内过程的理想选择。
• CdSe/ZnS Nanoparticle Composites with Amine-Functionalized Polyfluorene Derivatives for Polymeric Light-Emitting Diodes: Synthesis, Photophysical Properties, and the Electroluminescent Performance
  作者：Zeng-Shan Guo、Lihua Zhao、Jian Pei、Zhang-Lin Zhou、Gary Gibson、James Brug、Sity Lam、Samuel S. Mao

  DOI：10.1021/ma902573d

  日期：2010.2.23

  A series of amine-functionalized poly(9,9-dihexylfluorene) (PFH) derivatives, PFH-NH2F-39-1 (P1), PFH-NH2F-19-1 (P2), PFH-NH2F-9-1 (P3), and PFH-NH2F-17-3 (P4), and PFH-NH2F-4-1 (P5), were developed to form organic/inorganic hybrid composites with CdSc/ZnS nanoparticle for polymeric light-emitting diodes (LEDs). The structures and purities of all desired polymers were fully characterized by H-1 and C-13 NMR, UV-vis and photoluminescent spectroscopy, gel permeation chromatography, elemental analyses. The hybrid nanocomposites were in situ formed through these amino-functionalized polyfluorene derivatives doped with core-shell CdSe/ZnS quantum dots (QDs). The detailed characterizations of their photophysical properties revealed that rapid Forster energy transfer from the conjugatee polymers to the red-emitting QDs afforded an efficient red color emission. The preliminary polymeric LEDs fabrication with the configuration of ITO/DB/nanocompositcs/Al achieved red emission for the ill Situ prepared hybrid nanocomposites. The investigation of device performance indicates that these nanocomposites are promising red light-emitting polymeric LED materials with good performance in providing excellent color purity, stability, and robustness. Such strategy provides us a platform to achieve red-emitting hybrid nanocomposites as the active materials for LEDs.
• Hybrid Semiconducting Polymer Dot–Quantum Dot with Narrow-Band Emission, Near-Infrared Fluorescence, and High Brightness
  作者：Yang-Hsiang Chan、Fangmao Ye、Maria Elena Gallina、Xuanjun Zhang、Yuhui Jin、I-Che Wu、Daniel T. Chiu

  DOI：10.1021/ja3022973

  日期：2012.5.2

  This communication describes a new class of semiconducting polymer nanoparticle-quantum dot hybrid with high brightness, narrow emission, near-IR fluorescence, and excellent cellular targeting capability. Using this approach, we circumvented the current difficulty with obtaining narrow-band-emitting and near-IR-fluorescing semiconducting polymer nanoparticles while combining the advantages of both semiconducting polymer nanoparticles and quantum dots. We further demonstrated the use of this new class of hybrid nanomaterial for effective and specific cellular and subcellular labeling without any noticeable nonspecific binding. This hybrid nonmaterial is anticipated to find use in a variety of in vitro and in vivo biological applications.