3-ethoxycarbonyl-2-(3,5-dimethoxyphenyl)-2,5-dihydrofuran | 1289117-76-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-ethoxycarbonyl-2-(3,5-dimethoxyphenyl)-2,5-dihydrofuran
• 英文别名: Ethyl 2-(3,5-dimethoxyphenyl)-2,5-dihydrofuran-3-carboxylate
• CAS: 1289117-76-5
• 化学式: C₁₅H₁₈O₅
• 分子量: 278.305
• InChiKey: JEGDAGUEEAQTSF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  54
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-[(3,5-dimethoxyphenyl)hydroxymethyl]buta-2,3-dienoic acid ethyl ester 在 copper dichloride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 2.0h， 生成 ethyl 5,7-dimethoxy-2-naphthoate 、 3-ethoxycarbonyl-2-(3,5-dimethoxyphenyl)-2,5-dihydrofuran
  参考文献：
  名称：

  Copper-Catalyzed Intramolecular Hydroalkoxylation of α-(1-Hydroxy-1-alkyl- and -aryl)methylallenoates by a 5-Endo Mode for Preparation of 2-Alkyl- and 2-Aryl-2,5-dihydrofurans

  摘要：

  Ethyl alpha-(1-hydroxy-1-alkyl)methylallenoates and alpha-(1-hydroxy-1-aryl)methylallenoates containing not only electron-donating groups but also an electron-withdrawing group on the aryl group at the alpha-position have been shown to undergo an efficient and selective copper-catalyzed intramolecular hydroalkoxylation to give functionalized 3-ethoxycarbony1-2-alkyl- and -aryl-2,5-dihydrofurans in good to excellent yields through a 5-endo mode.

  DOI：

  10.1021/jo2018125

文献信息

• Copper-Catalyzed Intramolecular Hydroalkoxylation of α-(1-Hydroxy-1-alkyl- and -aryl)methylallenoates by a 5-<i>Endo</i> Mode for Preparation of 2-Alkyl- and 2-Aryl-2,5-dihydrofurans
  作者：Sanghyuck Kim、Phil Ho Lee

  DOI：10.1021/jo2018125

  日期：2012.1.6

  Ethyl alpha-(1-hydroxy-1-alkyl)methylallenoates and alpha-(1-hydroxy-1-aryl)methylallenoates containing not only electron-donating groups but also an electron-withdrawing group on the aryl group at the alpha-position have been shown to undergo an efficient and selective copper-catalyzed intramolecular hydroalkoxylation to give functionalized 3-ethoxycarbony1-2-alkyl- and -aryl-2,5-dihydrofurans in good to excellent yields through a 5-endo mode.