2-[5-(2-imidazolinyl)-2-benzimidazolyl]-5-[4-(2-imidazolinyl)phenyl]furan | 216308-23-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 2-[5-(2-imidazolinyl)-2-benzimidazolyl]-5-[4-(2-imidazolinyl)phenyl]furan
• 英文别名: DB302；6-(4,5-dihydro-1H-imidazol-2-yl)-2-[5-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]furan-2-yl]-1H-benzimidazole
• CAS: 216308-23-5
• 化学式: C₂₃H₂₀N₆O
• 分子量: 396.451
• InChiKey: YZJPVWWVBOFEMQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  30
• 可旋转键数：
  4
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  90.6
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-(5-cyano-2-benzimidazolyl)-5-(4-cyanophenyl)furan 在 盐酸 作用下， 以 乙醇 为溶剂， 反应 144.0h， 生成 2-[5-(2-imidazolinyl)-2-benzimidazolyl]-5-[4-(2-imidazolinyl)phenyl]furan
  参考文献：
  名称：

  Inhibition of the HIV-1 rev–RRE complex formation by unfused aromatic cations

  摘要：

  RNA viruses cause a wide range of human diseases. Development of new agents to target such viruses is an active area of research. Towards this goal, a series of diphenylfuran cations as potential inhibitors of the Rev-RRE complex have been designed and synthesized. Analysis of the interaction of the diphenylfurans with RRE and TAR RNA model systems by gel shift assays indicates that they exhibit both sequence and structure-dependent binding modes. Our results show a strong interaction between the diphenylfuran ring system and RRE bases, while the TAR interactions are much weaker with the compounds that are the best inhibitors of Rev-RRE. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(00)00344-8

文献信息

• Dicationic compounds which selectively recognize G-quadruplex DNA
  申请人：Wilson W. David

  公开号：US20100249175A1

  公开（公告）日：2010-09-30

  Dicationic compounds that are highly selective for binding G-quadruplex DNA are described. Several compounds exhibit groove binding toward G-quadruplex DNA and in vitro and in vivo activity versus Trypanosoma brucei rhodesiense. The compounds represent novel drugs for the treatment of cancer, malaria, leishmania, and trypanosomiasis.

  本文描述了高度选择性结合G四链体DNA的二阳离子化合物。几种化合物对G四链体DNA表现出凹槽结合的特性，并在体内外显示出对Trypanosoma brucei rhodesiense的活性。这些化合物代表了治疗癌症、疟疾、利什曼病和锥虫病的新型药物。
• Inhibition of the HIV-1 rev–RRE complex formation by unfused aromatic cations
  作者：G Xiao

  DOI：10.1016/s0968-0896(00)00344-8

  日期：2001.5

  RNA viruses cause a wide range of human diseases. Development of new agents to target such viruses is an active area of research. Towards this goal, a series of diphenylfuran cations as potential inhibitors of the Rev-RRE complex have been designed and synthesized. Analysis of the interaction of the diphenylfurans with RRE and TAR RNA model systems by gel shift assays indicates that they exhibit both sequence and structure-dependent binding modes. Our results show a strong interaction between the diphenylfuran ring system and RRE bases, while the TAR interactions are much weaker with the compounds that are the best inhibitors of Rev-RRE. (C) 2001 Elsevier Science Ltd. All rights reserved.