2-(3'-(p-methoxyphenyl)-4'-(p-methylphenylsulfonyl)isoxazol-5'-ylsulfonylmethyl)-4,5-dihydrooxazole | 1608119-26-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(3'-(p-methoxyphenyl)-4'-(p-methylphenylsulfonyl)isoxazol-5'-ylsulfonylmethyl)-4,5-dihydrooxazole
• 英文别名: 5-(4,5-Dihydro-1,3-oxazol-2-ylmethylsulfonyl)-3-(4-methoxyphenyl)-4-(4-methylphenyl)sulfonyl-1,2-oxazole；5-(4,5-dihydro-1,3-oxazol-2-ylmethylsulfonyl)-3-(4-methoxyphenyl)-4-(4-methylphenyl)sulfonyl-1,2-oxazole
• CAS: 1608119-26-1
• 化学式: C₂₁H₂₀N₂O₇S₂
• 分子量: 476.531
• InChiKey: NJFGXAGFMNDJNH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  32
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  142
• 氢给体数：
  0
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  2-(4',5'-dihydro-3'-(p-methoxyphenyl)-4'-(p-methylphenylsulfonyl)isoxazol-5'-ylsulfonylmethyl)-4,5-dihydrooxazole 在 四氯苯醌 作用下， 以 5,5-dimethyl-1,3-cyclohexadiene 为溶剂， 以60%的产率得到2-(3'-(p-methoxyphenyl)-4'-(p-methylphenylsulfonyl)isoxazol-5'-ylsulfonylmethyl)-4,5-dihydrooxazole
  参考文献：
  名称：

  Synthesis and antioxidant activity of pyrazolyl-oxazolines/thiazolines and isoxazolyl-oxazolines/thiazolines

  摘要：

  A new class of pyrazolyl/isoxazolyl-oxazolines and thiazolines were synthesized from E-arylsulfonylethenesulfonylacetic acid methyl ester and tested for antioxidant activity. Among the tested compounds, 14b exhibited excellent antioxidant activity when compared with the standard ascorbic acid.

  DOI：

  10.1007/s00044-013-0688-z

文献信息

• Synthesis and antioxidant activity of pyrazolyl-oxazolines/thiazolines and isoxazolyl-oxazolines/thiazolines
  作者：Adivireddy Padmaja、Chittoor Rajasekhar、Suram Durgamma、Bhumireddy Chinnachennaiahgari Venkatesh、Venkatapuram Padmavathi

  DOI：10.1007/s00044-013-0688-z

  日期：2014.3

  A new class of pyrazolyl/isoxazolyl-oxazolines and thiazolines were synthesized from E-arylsulfonylethenesulfonylacetic acid methyl ester and tested for antioxidant activity. Among the tested compounds, 14b exhibited excellent antioxidant activity when compared with the standard ascorbic acid.