2,3,10,10a-tetrahydro-1H-pyrrolo<1,2-b><1,2,4>benzothiadiazine 5,5-dioxide | 72923-05-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻二嗪
• 英文名称: 2,3,10,10a-tetrahydro-1H-pyrrolo<1,2-b><1,2,4>benzothiadiazine 5,5-dioxide
• 英文别名: 2,3,10,10a-tetrahydro-1H-benzo[e]pyrrolo[1,2-b][1,2,4]thiadiazine 5,5-dioxide；1,2,3,5,10,10a-Hexahydrobenzo[e]pyrrolo[1,2-b]-1,2,4-thiadiazine-5,5-dioxide；2,3,10,10a-tetrahydro-1H-pyrrolo[1,2-b][1,2,4]benzothiadiazine 5,5-dioxide
• CAS: 72923-05-8
• 化学式: C₁₀H₁₂N₂O₂S
• 分子量: 224.283
• InChiKey: RWUDZOCZVQBJNI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  57.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  N-(2-nitrophenylsulphonyl)pyrrolidine-2-carboxylic acid 在 ammonium hydroxide 、 氯化亚砜 、 铁粉 作用下， 以 二氯甲烷 、 溶剂黄146 、 苯 为溶剂， 反应 10.5h， 生成 2,3,10,10a-tetrahydro-1H-pyrrolo<1,2-b><1,2,4>benzothiadiazine 5,5-dioxide
  参考文献：
  名称：

  Alo, Babajide I.; Adegoke, Emmanuel A.; Ligali-Ali, Mamoudou, Journal of the Chemical Society. Perkin transactions I, 1986, p. 805 - 808

  摘要：

  DOI：

文献信息

• Novel compounds and their use as positive AMPA receptor modulators
  申请人：Neurosearch A/S.

  公开号：US20040043987A1

  公开（公告）日：2004-03-04

  The invention provides novel compounds represented by the general formula 5 compound represented by the formula: 1 wherein the bond represented by the broken line may be a single, a double bond or absent; and if the bond is absent, then the nitrogen is substituted with a hydrogen and R 2 ; X represents SO 2 or C═O or CH 2 ; Y represents —CH(R 4 )—, —N(R 4 )— or —N(R 4 )—CH 2 —, O; and the meaning of R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , and R 8 are as defined in the application The compounds are useful as positive modulators of the AMPA-receptor.

  该发明提供了一种新型化合物，其通式5的化合物如下所示：其中由虚线表示的键可以是单键、双键或不存在；如果键不存在，则氮原子用氢和R2取代；X代表SO2或C═O或CH2；Y代表—CH(R4)—、—N(R4)—或—N(R4)—CH2—、O；R2、R3、R4、R5、R6、R7和R8的含义如申请中所定义。这些化合物可用作AMPA受体的阳性调节剂。
• Synthesis of Benzothiadiazines, Benzothiadiazepines, and Benzothiadiazocines from Intramolecular Azide Reactions and Iodocyclisations
  作者：Karl Hemming、Nilesh Patel、Christopher Chambers

  DOI：10.1055/s-0029-1218278

  日期：2009.11

  N-Homoallyl-substituted (2-aminoaryl)sulfonamides undergo intramolecular iodocyclisation to furnish aziridine-fused 1,2,6-benzothiadiazocines. The identical aziridine-fused 1,2,6-benzothiadiazocines were also available from an intramolecular azide to alkene 1,3-diploar cycloaddition involving the corresponding N-homoallylic (2-azidoaryl)sulfonamides in boiling carbon tetrachloride. The use of boiling DMF as solvent for the same reaction gave pyrrolo-fused benzothiadiazines. Intramolecular azide-alkene cycloadditions also allowed access to aziridine-fused pyrrolobenzothiadiazepines and pyrrolobenzodiazepines.

  N-高烯丙基取代的（2-氨基芳基）磺酰胺经过分子内碘环化反应生成了氮丙啶融合的 1,2,6-苯并噻二唑并[1,2,6-benzothiadiazocines]。在沸腾的四氯化碳中，用相应的 N-(2-叠氮芳基)磺酰胺进行分子内叠氮到烯烃的 1,3-二环加成反应，也可以得到相同的叠氮基融合的 1,2,6-苯并噻二唑并类化合物。使用沸腾的 DMF 作为溶剂进行相同的反应，可得到吡咯并融合的苯并噻二嗪。分子内叠氮-烯环加成反应还可以得到叠氮基融合的吡咯并噻二氮杂卓和吡咯并二氮杂卓。
• Compounds and their use as positive AMPA receptor modulators
  申请人：NeuroSearch A/S

  公开号：US07235548B2

  公开（公告）日：2007-06-26

  The invention provides novel compounds represented by the general formula compound represented by the formula: wherein the bond represented by the broken line may be a single, a double bond or absent; and if the bond is absent, then the nitrogen is substituted with a hydrogen and R2; X represents SO2 or C═O or CH2; Y represents —CH(R4)—, —N(R4)— or —N(R4)—CH2—, O; and the meaning of R2, R3, R4, R5, R6, R7, and R8 are as defined in the application The compounds are useful as positive modulators of the AMPA-receptor.

  本发明提供了由一般式化合物表示的新化合物，该一般式化合物由以下式子表示：其中，由断线表示的键可以是单键、双键或不存在；如果键不存在，则氮被氢和R2取代；X代表SO2、C═O或CH2；Y代表—CH(R4)—、—N(R4)—或—N(R4)—CH2—、O；而R2、R3、R4、R5、R6、R7和R8的含义如申请书中所定义。这些化合物可用作AMPA受体的正向调节剂。
• ADESOGAN E. K.; ALO B. I., J. CHEM. SOC. CHEM. COMMUN., 1979, NO 16, 673-674
  作者：ADESOGAN E. K.、 ALO B. I.

  DOI：——

  日期：——
• ALO, B. I.;ADEGOKE, E. A.;LIGALI-ALI, M.;ADESOGAN, E. K., J. CHEM. SOC. PERKIN TRANS., 1986, N 5, 805-808
  作者：ALO, B. I.、ADEGOKE, E. A.、LIGALI-ALI, M.、ADESOGAN, E. K.

  DOI：——

  日期：——