(2,3,5,6-tetrafluorophenyl)phosphinic acid | 1255084-60-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2,3,5,6-tetrafluorophenyl)phosphinic acid
• CAS: 1255084-60-6
• 化学式: C₆H₃F₄O₂P
• 分子量: 214.056
• InChiKey: PMEJDQALQTWNIA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.34
• 重原子数：
  13.0
• 可旋转键数：
  1.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  37.3
• 氢给体数：
  1.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  (2,3,5,6-tetrafluorophenyl)phosphinic acid 、 丙酮 反应 504.0h， 以52%的产率得到(2-hydroxypropan-2-yl)(2,3,5,6-tetrafluorophenyl)phosphinic acid
  参考文献：
  名称：

  P–C bond formation via P–H addition of a fluoroaryl phosphinic acid to ketones

  摘要：

  The synthesis, structure and reactivity of the fluoroaryl phosphinic acid HF(4)C(6)-P(O)HOH is reported and compared to a sterically comparable yet non-fluorinated analog with similar size. The fluoroaryl phosphinic acid undergoes reversible P-H addition to the carbonyl functionality of ketones under formation of a P-C bond which is retained in the resulting alpha-hydroxy phosphinic acid. The latter shows an extended 2D hydrogen bonded network in the solid state. (C) 2010 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jfluchem.2010.07.008
• 作为产物：
  描述：

  Mes-PH(=O)OH 在 水 作用下， 以 氯仿 为溶剂， 以99%的产率得到(2,3,5,6-tetrafluorophenyl)phosphinic acid
  参考文献：
  名称：

  P–C bond formation via P–H addition of a fluoroaryl phosphinic acid to ketones

  摘要：

  The synthesis, structure and reactivity of the fluoroaryl phosphinic acid HF(4)C(6)-P(O)HOH is reported and compared to a sterically comparable yet non-fluorinated analog with similar size. The fluoroaryl phosphinic acid undergoes reversible P-H addition to the carbonyl functionality of ketones under formation of a P-C bond which is retained in the resulting alpha-hydroxy phosphinic acid. The latter shows an extended 2D hydrogen bonded network in the solid state. (C) 2010 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jfluchem.2010.07.008