3-hydrazino-5,6-dihydrobenzocinnoline | 107127-48-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 3-hydrazino-5,6-dihydrobenzocinnoline
• 英文别名: 3-hydrazino-5,6-dihydro-benzo[h]cinnoline；3-hydrazinyl-5,6-dihydrobenzo[h]cinnoline；5,6-Dihydro-3-hydrazinobenzo(H)cinnoline；5,6-dihydrobenzo[h]cinnolin-3-ylhydrazine
• CAS: 107127-48-0
• 化学式: C₁₂H₁₂N₄
• 分子量: 212.254
• InChiKey: PCTYKUOPQTXPNF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  63.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-hydrazino-5,6-dihydrobenzocinnoline 在 镍 氢气 作用下， 以 甲醇 为溶剂， 反应 4.0h， 生成 5,6-二氢-苯并并[h]肉啉-3-胺
  参考文献：
  名称：

  Discovery of a 3-Amino-6-phenyl-pyridazine Derivative as a New Synthetic Antineuroinflammatory Compound

  摘要：

  Excessive glial activation, with overproduction of cytokines and oxidative stress products, is detrimental and a hallmark of neurodegenerative disease pathology. Suppression of glial activation is a potential therapeutic approach, and protein kinases are targets of some antiinflammatory drugs. To address an unmet need for selective inhibitors of glial activation, we developed a novel 3-amino-6-phenylpyridazine derivative that selectively blocks increased IL-1beta, iNOS, and NO production by activated glia, without inhibition of potentially beneficial glial functions.

  DOI：

  10.1021/jm015573g
• 作为产物：
  描述：

  2,3,5,6-Tetrahydrobenzo[h]cinnolin-3-one 在 一水合肼 、 三氯氧磷 作用下， 反应 26.5h， 生成 3-hydrazino-5,6-dihydrobenzocinnoline
  参考文献：
  名称：

  Ravina; Fueyo; Teran, Pharmazie, 1992, vol. 47, # 8, p. 574 - 577

  摘要：

  DOI：

文献信息

• SUBSTITUTED TRIAZOLES USEFUL AS AXL INHIBITORS
  申请人：Goff Dane

  公开号：US20080188474A1

  公开（公告）日：2008-08-07

  Substituted triazoles and pharmaceutical compositions containing the compounds are disclosed as being useful in inhibiting the activity of the receptor protein tyrosine kinase Axl. Methods of using the compounds in treating diseases or conditions associated with Axl activity are also disclosed.

  本发明揭示了替代三唑和含有该化合物的制药组合物，其在抑制受体蛋白酪氨酸激酶Axl的活性方面是有用的。还揭示了使用该化合物治疗与Axl活性相关的疾病或病况的方法。
• PYRIDAZINE COMPOUNDS AND METHODS
  申请人：Watterson Martin

  公开号：US20090029985A1

  公开（公告）日：2009-01-29

  The invention relates to novel chemical compounds, compositions and methods of making and using the same. In particular, the invention provides pyridazine compounds and/or related heterocyclic derivatives, compositions comprising the same, and methods of using pyridazine compounds and/or related heterocyclic derivatives and compositions comprising the same, for modulation of cellular pathways (e.g., signal transduction pathways), for treatment or prevention of inflammatory diseases (e.g., Alzheimer's disease), for research, drug screening, and therapeutic applications.

  本发明涉及新型化学化合物、组合物及其制备和使用的方法。具体而言，本发明提供了吡嗪化合物和/或相关的杂环衍生物，包括这些化合物的组合物，以及使用吡嗪化合物和/或相关的杂环衍生物和组合物的方法，用于调节细胞通路（例如信号转导通路），用于治疗或预防炎症性疾病（例如阿尔茨海默氏病），用于研究、药物筛选和治疗应用。
• Substituted triazoles useful as AXl inhibitors
  申请人：Goff Dane

  公开号：US08906922B2

  公开（公告）日：2014-12-09

  Substituted triazoles and pharmaceutical compositions containing the compounds are disclosed as being useful in inhibiting the activity of the receptor protein tyrosine kinase Axl. Methods of using the compounds in treating diseases or conditions associated with Axl activity are also disclosed.

  本发明揭示了替代三唑和含有该化合物的制药组合物，被用于抑制受体蛋白酪氨酸激酶Axl的活性。还揭示了使用该化合物治疗与Axl活性相关的疾病或病情的方法。
• Substituted triazoles useful as Axl inhibitors
  申请人：Rigel Pharmaceuticals, Inc.

  公开号：US09353126B2

  公开（公告）日：2016-05-31

  Substituted triazoles and pharmaceutical compositions containing the compounds are disclosed as being useful in inhibiting the activity of the receptor protein tyrosine kinase Axl. Methods of using the compounds in treating diseases or conditions associated with Axl activity are also disclosed.

  本文披露了替代的三唑并含有这些化合物的制药组合物，可以用于抑制受体蛋白酪氨酸激酶Axl的活性。还披露了使用这些化合物治疗与Axl活性相关的疾病或病症的方法。
• Substituted triazoles useful as AXL inhibitors
  申请人：Rigel Pharmaceuticals, Inc.

  公开号：EP2476679A2

  公开（公告）日：2012-07-18

  Substituted triazoles and pharmaceutical compositions containing the compounds are disclosed as being useful in inhibiting the activity of the receptor protein tyrosine kinase Axl. Methods of using the compounds in treating diseases or conditions associated with Axl activity are also disclosed.

  所公开的取代三唑类化合物和含有这些化合物的药物组合物有助于抑制受体蛋白酪氨酸激酶 Axl 的活性。还公开了使用这些化合物治疗与 Axl 活性相关的疾病或病症的方法。