O-isopropyl isopropylfluorophosphonate | 665-33-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 英文名称: O-isopropyl isopropylfluorophosphonate
• 英文别名: isopropyl-phosphonic acid-fluoride-isopropyl ester；Isopropyl-phosphonsaeure-fluorid-isopropylester；Phosphonofluoridic acid, (1-methylethyl)-, 1-methylethyl ester；2-[fluoro(propan-2-yl)phosphoryl]oxypropane
• CAS: 665-33-8
• 化学式: C₆H₁₄FO₂P
• 分子量: 168.148
• InChiKey: TYNDGPJILGOQAF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  Isopropyl isopropylphosphonochloridate 在 TBAF(tBuOH)4 作用下， 以 乙腈 为溶剂， 反应 0.08h， 以85%的产率得到O-isopropyl isopropylfluorophosphonate
  参考文献：
  名称：

  四（叔丁醇）四丁基铵配位氟化物-一种合成磷（V）化合物氟衍生物的有效试剂

  摘要：

  使用固体试剂四（叔丁醇）配位的四丁基铵可实现氯化磷（V）直接转化为相应的氟化磷（V）。直接合成了氟（V）氟化物，并以非常高的收率有效地进行了分离。

  DOI：

  10.1016/j.tetlet.2009.03.151

文献信息

• RADIOIMAGING MOIETIES COUPLED TO PEPTIDASE-BINDING MOIETIES FOR IMAGING TISSUES AND ORGANS THAT EXPRESS PEPTIDASES
  申请人：Molecular Insight Pharmaceuticals, Inc.

  公开号：EP2061518A2

  公开（公告）日：2009-05-27
• RECOMBINANT ORGANOPHOSPHOROUS ACID ANHYDRASE AND METHODS OF USE
  申请人：MCDANIEL C. STEVEN

  公开号：US20080206834A1

  公开（公告）日：2008-08-28

  The bacterial gene (opd) encodes an organophosphorus anhydrase which is capable of hydrolyzing a wide spectrum of neurotoxins ranging from insecticides to mammalian neurotoxins. The cloned gene has been expressed in a number of hosts and the purified enzyme has been characterized. These advances have led to a number of interrelated uses for the cloned gene and the recombinant enzyme including: detoxification of organophosphorus compounds; detection of organophosphorus compounds; protection of susceptible organisms from organophosphorus poisoning; and, detection of organophosphorus-detoxifying microorganisms.
• RADIOIMAGING MOIETIES COUPLED TO PEPTIDEASE-BINDING MOIETIES FOR IMAGING TISSUES AND ORGANS THAT EXPRESS PEPTIDASES
  申请人：Babich J. W.

  公开号：US20080213172A1

  公开（公告）日：2008-09-04

  Conjugates, methods and kits are described for imaging tissues and organs that express one or more peptidases. In a preferred embodiment of the invention, a series of di-(2-pyridylmethyl)amine (D) ligands, which can bind M(CO) 3 + [M=Tc or Re], were coupled to lisinopril (L). Aliphatic tethers with varying number of methylene groups (3, 4, 5, and 7; D(C 4 )L, D(C 5 )L, D(C 6 )L, and D(C 8 )L, respectively) were utilized, with in vitro inhibitory activity increasing with increasing number of methylene groups. The D(C 8 )L conjugate was observed to be significantly more potent than D(C 4 )L. In vivo specificity for ACE was studied in both tissue distribution and gamma imaging studies, demonstrating localization in tissues with high ACE content. Localization was blocked by pretreatment with lisinopril.
• Compositions and combinations of organophosphorus bioscavengers and hyaluronan-degrading enzymes, and methods of use
  申请人：Troyer John K.

  公开号：US20130071394A1

  公开（公告）日：2013-03-21

  Provided are compositions and combinations containing an organophosphorus bioscavenger and a hyaluronan-degrading enzyme. The provided compositions and combinations can be used to treat or prevent organophosphorus poisoning, including nerve agent poisoning and pesticide poisoning.
• [EN] RADIOIMAGING MOIETIES COUPLED TO PEPTIDASE-BINDING MOIETIES FOR IMAGING TISSUES AND ORGANS THAT EXPRESS PEPTIDASES<br/>[FR] FRAGMENTS DE RADIO-IMAGERIE COUPLÉS À DES FRAGMENTS DE LIAISON AUX PEPTIDASES PERMETTANT D'IMAGER DES TISSUS ET DES ORGANES EXPRIMANT DES PEPTIDASES
  申请人：MOLECULAR INSIGHT PHARM INC

  公开号：WO2008028000A2

  公开（公告）日：2008-03-06

  [EN] Conjugates, methods and kits are described for imaging tissues and organs that express one or more peptidases. In a preferred embodiment of the invention, a series of di-(2-pyridylmethyl)amine (D) ligands, which can bind M(CO)₃ ⁺
  [FR] La présente invention concerne des conjugués, des procédés et des trousses permettant d'imager des tissus et des organes exprimant une ou plusieurs peptidases. Dans un mode de réalisation préféré de cette invention, une série de ligands de di-(2-pyridylméthyl)amine (D), qui peuvent lier M(CO)₃ ⁺