1-Methylphosphorinan-1-oxid | 39763-49-0

• 分子结构分类: 有机化合物 - 有机磷化合物 - 有机膦及其衍生物
• 英文名称: 1-Methylphosphorinan-1-oxid
• 英文别名: 1-methyl-phosphinane 1-oxide；1-Methyl-1lambda5-phosphinane 1-oxide；1-methyl-1λ5-phosphinane 1-oxide
• CAS: 39763-49-0
• 化学式: C₆H₁₃OP
• 分子量: 132.142
• InChiKey: QJHFNIXWDWGHAR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-Methylphosphorinan-1-oxid 在 苯硅烷 作用下， 生成 1-Methylphosphorinan
  参考文献：
  名称：

  Alkaline cleavage reactions of tetraalkylphosphonium salts

  摘要：

  DOI：

  10.1021/ja00782a035
• 作为产物：
  描述：

  1-phenylphosphinane 在 sodium hydroxide 作用下， 生成 1-Methylphosphorinan-1-oxid
  参考文献：
  名称：

  Alkaline cleavage reactions of tetraalkylphosphonium salts

  摘要：

  DOI：

  10.1021/ja00782a035

文献信息

• Solid State Polymerization Process for Polyester with Phosphinic Acid Compounds
  申请人：Odorisio Paul

  公开号：US20130035451A1

  公开（公告）日：2013-02-07

  Disclosed are phosphinic acid compounds of formula I, II or III where R 1 and R 1 ′ are for instance straight or branched C 1 -C 50 alkyl, R 2 is for instance straight or branched C 22 -C 50 alkyl, R 3 and R 3 ′ are for instance straight or branched C 1 -C 50 alkyl, R 4 is for instance straight or branched C 1 -C 50 alkylene and m is from 2 to 100. Also disclosed are polyester compositions comprising the compounds of formula I, II and III.

  公开的是化学式I、II或III的膦酸化合物，其中R1和R1'例如是直链或支链的C1-C50烷基，R2例如是直链或支链的C22-C50烷基，R3和R3'例如是直链或支链的C1-C50烷基，R4例如是直链或支链的C1-C50烷基，m为2至100。还公开了包含化学式I、II和III的聚酯组合物。
• [EN] SUBSTITUTED BICYCLIC COMPOUNDS AS INHIBITORS OF EZH2<br/>[FR] COMPOSÉS BICYCLIQUES SUBSTITUÉS UTILISÉS COMME INHIBITEURS D'EZH2
  申请人：PIRAMAL ENTPR LTD

  公开号：WO2014155301A1

  公开（公告）日：2014-10-02

  The present invention provides compounds of formula 1, isotopic forms, stereoisomers or tautomers thereof, or pharmaceutically acceptable salts, solvates, N-oxides, S-oxides and polymorphs thereof, and processes for their preparation. The invention further relates to pharmaceutical compositions containing said compounds and their use in the treatment of diseases or disorders mediated by EZH2 (enhancer of zeste homolog 2), particularly cancer.

  本发明提供了公式1的化合物，其同位素形式、立体异构体或互变异构体，或其药用可接受的盐、溶剂化合物、N-氧化物、S-氧化物和多晶形式，以及其制备方法。本发明还涉及含有所述化合物的药物组合物，并其在治疗由EZH2（zeste同源物增强子2）介导的疾病或紊乱中的应用，特别是癌症。
• SOLVOLYSIS OF PHOSPHONIUM COMPOUNDS CONTAINING A THIOPHENOXY GROUP LINKED TO PHOSPHORUS
  作者：Gunnar Aksnes

  DOI：10.1080/10426509608037953

  日期：1996.8.1

  Abstract A kinetic study of the solvolysis of six alkylphenyl thiophenoxyphosphonium chlorides in 50% water/methanol is reported. The rates of solvolysis, where thiophenol and phosphine oxides are formed, are little influenced by the substituents linked to phosphorus. The present findings are in sharp contrast to the 104 higher rate of the alkaline decomposition of tetraphenyl as compared to tialkylphenyl

  摘要 报道了六种烷基苯基噻吩氧基氯化鏻在 50% 水/甲醇中的溶剂分解动力学研究。形成苯硫酚和氧化膦的溶剂分解速率几乎不受与磷相连的取代基的影响。本发现与四苯基的碱性分解速率比三烷基苯基鏻盐高 104 形成鲜明对比，其中苯基是离去基团。此外，环状苯基噻吩氧基鏻盐的溶剂分解速率几乎与相应的二烷基苯基噻吩氧基鏻化合物的速率相同。噻吩氧基鏻化合物溶剂分解的活化参数的计算表明，潜在的反应力，表示为活化能和熵，受取代基的影响很大。结果表明，噻吩氧基从五价、三方双锥反应中间体中排出，然后在假旋...
• First ever observation of the intermediate of phosphonium salt and ylide hydrolysis: P-hydroxytetraorganophosphorane
  作者：Peter A. Byrne、Yannick Ortin、Declan G. Gilheany

  DOI：10.1039/c4cc08644a

  日期：——

  long-postulated intermediate in phosphonium salt and ylide hydrolysis, has been observed and characterised by low temperature NMR, finally definitively establishing its involvement in these reactions. The results require modification of the previously accepted mechanism for ylide hydrolysis: P-hydroxytetraorganophosphorane is generated directly by 4-centre reaction of ylide with water.

  对-羟基四有机磷烷，在phospho盐和叶立德水解中被长期假定的中间体，已经被观察到并通过低温NMR进行了表征，最终确定了它参与了这些反应。结果需要修改以前接受的内酯水解机理：对羟基四有机磷盐直接与内酯发生4中心反应生成P-羟基四有机磷烷。
• Solid state polymerization process for polyester with phosphinic acid compounds
  申请人：Odorisio Paul

  公开号：US20090253888A1

  公开（公告）日：2009-10-08

  Disclosed is a method for increasing the solid state polymerization (SSP) rates of metal catalyzed polyesters. The method comprises in a first step, reacting a dicarboxylic acid or a C 1 -C 4 dicarboxylic diester with a diol at a suitable temperature and pressure to effect esterification or transesterification to prepare a precondensate and in a second step, reacting the precondensate to effect polycondensation at a suitable temperature and pressure to prepare a high molecular weight polyester and in a third step, further increasing the molecular weight and viscosity of the polyester under SSP conditions of a suitable temperature and pressure, where a metal catalyst is added in the first step or in the second step as a reaction catalyst, and where a certain phosphinic acid compound is added in the first step, in the second step or just prior to the third step. The polyester product exhibits low aldehyde formation during melt processing steps as well as excellent color.

  本发明揭示了一种提高金属催化聚酯固态聚合(SSP)速率的方法。该方法包括以下步骤：第一步，在适宜的温度和压力下将二羧酸或C1-C4二羧酸二酯与二元醇反应，以进行酯化或转酯化反应，制备预聚物；第二步，在适宜的温度和压力下，将预聚物进行聚合反应，制备高分子量聚酯；第三步，在适宜的温度和压力下，在SSP条件下进一步提高聚酯的分子量和粘度，其中在第一步或第二步中加入金属催化剂作为反应催化剂，并在第一步、第二步或第三步前加入特定的膦酸化合物。该聚酯产品在熔融加工过程中具有低醛类物质形成以及优异的颜色。