1-chloro-1-p.toluenesulphonylacetone | 101246-34-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-chloro-1-p.toluenesulphonylacetone
• 英文别名: 1-chloro-1-(toluene-4-sulfonyl)-acetone；(+/-)-1-Chlor-1-p-tolylsulfon-aceton；1-Chlor-1-(toluol-4-sulfonyl)-aceton；1-Chloro-1-(4-methylbenzene-1-sulfonyl)propan-2-one；1-chloro-1-(4-methylphenyl)sulfonylpropan-2-one
• CAS: 101246-34-8
• 化学式: C₁₀H₁₁ClO₃S
• 分子量: 246.715
• InChiKey: JVACZWYDJHXNNJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  59.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-chloro-1-p.toluenesulphonylacetone 在 sodium hydroxide 作用下， 反应 0.5h， 以96%的产率得到对甲苯磺酰氯甲烷
  参考文献：
  名称：

  Chemoselective mono halogenation of β-keto-sulfones using potassium halide and hydrogen peroxide; synthesis of halomethyl sulfones and dihalomethyl sulfones

  摘要：

  The synthesis of alpha-halo beta-keto-sulfones using potassium halide and hydrogen peroxide as a chemoselective mono halogenation reagent and the synthesis of alpha, alpha-symmetrical and asymmetrical dihalo beta-keto-sulfones and alpha-halo, alpha-alkyl and beta-keto-sulfones is described. Base induced cleavage of alpha-halo beta-keto-sulfones, alpha,alpha-dihalo beta-keto-sulfones, and alpha-halo, alpha-alkyl beta-keto-sulfones afforded the corresponding halomethyl sulfones, dihalomethyl sulfones and haloalkyl sulfones. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.11.129
• 作为产物：
  描述：

  4-甲苯磺酰丙酮 在 potassium chloride 、 双氧水 作用下， 以 丙酮 为溶剂， 反应 6.0h， 以96%的产率得到1-chloro-1-p.toluenesulphonylacetone
  参考文献：
  名称：

  Chemoselective mono halogenation of β-keto-sulfones using potassium halide and hydrogen peroxide; synthesis of halomethyl sulfones and dihalomethyl sulfones

  摘要：

  The synthesis of alpha-halo beta-keto-sulfones using potassium halide and hydrogen peroxide as a chemoselective mono halogenation reagent and the synthesis of alpha, alpha-symmetrical and asymmetrical dihalo beta-keto-sulfones and alpha-halo, alpha-alkyl and beta-keto-sulfones is described. Base induced cleavage of alpha-halo beta-keto-sulfones, alpha,alpha-dihalo beta-keto-sulfones, and alpha-halo, alpha-alkyl beta-keto-sulfones afforded the corresponding halomethyl sulfones, dihalomethyl sulfones and haloalkyl sulfones. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.11.129

文献信息

• Arylazomethylenetriphenylphosphoranes: intra molecular reactions with aldonitronyl substituents in the ortho position with respect to the azophosphorane group
  作者：A. Alemagna、P. Del Buttero、E. Licandro、A. Papagni、M. Ballabio

  DOI：10.1016/s0040-4020(01)96646-3

  日期：1985.1
• Ohta; Sudo; Sato, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1949, vol. 69, p. 47,49
  作者：Ohta、Sudo、Sato

  DOI：——

  日期：——
• ALEMAGNA, A.;DEL, BUTTERO, P.;LICANDRO, E.;PAPAGNI, A.;BALLABIO, M., TETRAHEDRON, 1985, 41, N 12, 2503-2511
  作者：ALEMAGNA, A.、DEL, BUTTERO, P.、LICANDRO, E.、PAPAGNI, A.、BALLABIO, M.

  DOI：——

  日期：——
• Chemoselective mono halogenation of β-keto-sulfones using potassium halide and hydrogen peroxide; synthesis of halomethyl sulfones and dihalomethyl sulfones
  作者：N. Suryakiran、P. Prabhakar、T. Srikanth Reddy、K. Chinni Mahesh、K. Rajesh、Y. Venkateswarlu

  DOI：10.1016/j.tetlet.2006.11.129

  日期：2007.1

  The synthesis of alpha-halo beta-keto-sulfones using potassium halide and hydrogen peroxide as a chemoselective mono halogenation reagent and the synthesis of alpha, alpha-symmetrical and asymmetrical dihalo beta-keto-sulfones and alpha-halo, alpha-alkyl and beta-keto-sulfones is described. Base induced cleavage of alpha-halo beta-keto-sulfones, alpha,alpha-dihalo beta-keto-sulfones, and alpha-halo, alpha-alkyl beta-keto-sulfones afforded the corresponding halomethyl sulfones, dihalomethyl sulfones and haloalkyl sulfones. (c) 2006 Elsevier Ltd. All rights reserved.