2-(2-methylprop-1-en-1-yl)pyrrolidine | 1008782-61-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 2-(2-methylprop-1-en-1-yl)pyrrolidine
• 英文别名: 2-(2-methyl-prop-1-enyl)-pyrrolidine；2-(2-methylpropenyl)pyrrolidine；2-(2-methylprop-1-enyl)pyrrolidine
• CAS: 1008782-61-3
• 化学式: C₈H₁₅N
• mdl: MFCD19227487
• 分子量: 125.214
• InChiKey: HBYPUMBAQKKYLU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  6-methyl-hepta-4,5-dienylamine 在 N-[(2S)-3-hydroxy-3-methyl-1-phenylbutan-2-yl]-4-(trifluoromethyl)benzenesulfonamide 、 五(二甲氨基)钽(V) 作用下， 以 氘代苯 为溶剂， 反应 71.0h， 生成 2-(2-methylprop-1-en-1-yl)pyrrolidine 、 2-(2-methylprop-1-en-1-yl)pyrrolidine
  参考文献：
  名称：

  Asymmetric hydroamination of aminoallenes catalyzed by titanium and tantalum complexes of chiral sulfonamide alcohol ligands

  摘要：

  A series of bidentate sulfonamide alcohol ligands with varying steric and electronic properties was synthesized. The titanium and tantalum complexes of these ligands, prepared in situ from either Ti(NMe2)(4) or Ta(NMe2)(5), were used as catalysts for the asymmetric hydroamination of 6-methyl-hepta-4,5-dienylamine, giving exclusively the alpha-vinylpyrrolidine product. The titanium derived catalysts gave products with low stereoselectivity, up to 11% ee favoring (+)-2-(2-methyl-propenyl)-pyrrolidine, while the tantalum derived catalysts gave products with higher and opposite stereoselectivity, up to 34% ee favoring (-)-2-(2-methyl-propenyl)-pyrrolidine. (C) 2010 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jorganchem.2010.08.001