3-(4-bromo-benzyl)-3-methyloxetane | 474888-56-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-(4-bromo-benzyl)-3-methyloxetane
• 英文别名: 3-[(4-Bromophenyl)methyl]-3-methyloxetane；3-[(4-bromophenyl)methyl]-3-methyloxetane
• CAS: 474888-56-7
• 化学式: C₁₁H₁₃BrO
• 分子量: 241.128
• InChiKey: PDEVYBNWXCXYSQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3-(4-bromo-benzyl)-3-methyloxetane 在 正丁基锂 、 四氯化硅 作用下， 以 四氢呋喃 为溶剂， 以48%的产率得到Tetrakis-[4-(3-methyl-oxetan-3-ylmethyl)-phenyl]-silane
  参考文献：
  名称：

  EXPO3000—a new expandable polymer for synthesis and enzymatic assays

  摘要：

  A new polymer for synthesis and enzymatic assays is presented which combines moderate loading with the biocompatibility of poly(ethylene glycol)-based resins. The polymer displays low swelling in all solvents until selective cleavage of a silyl based crosslinker expands the polar resin to render it penetratable for enzymes (an example with a 27 kDa protease is given). An efficient alkylation procedure for derivatization of long PEG-chains is also presented. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)01369-2
• 作为产物：
  描述：

  3-溴甲基-3-甲基-1-氧杂环丁烷 、 1,4-二溴苯 在 正丁基锂 作用下， 以 四氢呋喃 为溶剂， 以67%的产率得到3-(4-bromo-benzyl)-3-methyloxetane
  参考文献：
  名称：

  EXPO3000—a new expandable polymer for synthesis and enzymatic assays

  摘要：

  A new polymer for synthesis and enzymatic assays is presented which combines moderate loading with the biocompatibility of poly(ethylene glycol)-based resins. The polymer displays low swelling in all solvents until selective cleavage of a silyl based crosslinker expands the polar resin to render it penetratable for enzymes (an example with a 27 kDa protease is given). An efficient alkylation procedure for derivatization of long PEG-chains is also presented. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)01369-2

文献信息

• EXPO3000—a new expandable polymer for synthesis and enzymatic assays
  作者：Christian W. Tornøe、Morten Meldal

  DOI：10.1016/s0040-4039(02)01369-2

  日期：2002.9

  A new polymer for synthesis and enzymatic assays is presented which combines moderate loading with the biocompatibility of poly(ethylene glycol)-based resins. The polymer displays low swelling in all solvents until selective cleavage of a silyl based crosslinker expands the polar resin to render it penetratable for enzymes (an example with a 27 kDa protease is given). An efficient alkylation procedure for derivatization of long PEG-chains is also presented. (C) 2002 Elsevier Science Ltd. All rights reserved.