2-[(Thien-2-ylmethoxy)methyl]oxirane | 80910-06-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 杂芳族化合物
• 英文名称: 2-[(Thien-2-ylmethoxy)methyl]oxirane
• 英文别名: 2-(thiophen-2-ylmethoxymethyl)oxirane
• CAS: 80910-06-1
• 化学式: C₈H₁₀O₂S
• mdl: MFCD06655034
• 分子量: 170.232
• InChiKey: HHAXOENJRXKJRX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  50
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 危险性防范说明：
  P501,P261,P270,P202,P210,P201,P271,P264,P280,P370+P378,P308+P313,P337+P313,P305+P351+P338,P362+P364,P332+P313,P301+P312+P330,P302+P352+P312,P304+P340+P312,P403+P235,P405
• 危险性描述：
  H302+H312+H332,H315,H319,H341,H227

反应信息

• 作为反应物：
  描述：

  辛胺 、 2-[(Thien-2-ylmethoxy)methyl]oxirane 以 甲醇 为溶剂， 以58%的产率得到1-(Octylamino)-3-(thiophen-2-ylmethoxy)propan-2-ol
  参考文献：
  名称：

  Synthesis and Antibacterial Activity of Aromatic and Heteroaromatic Amino Alcohols

  摘要：

  Two series of aromatic and heteroaromatic amino alcohols were synthesized from alcohols and aldehydes and evaluated for their antibacterial activities. All the octylated compounds displayed a better activity against the four bacteria tested when evaluated by the agar diffusion method and were selected for the evaluation of minimal inhibitory concentration. The best results were obtained for p‐octyloxybenzyl derivatives against Staphylococcus epidermidis (minimal inhibitory concentrations = 32 μm).

  DOI：

  10.1111/j.1747-0285.2011.01231.x
• 作为产物：
  描述：

  2-噻吩甲醇 、 环氧氯丙烷 在 四丁基溴化铵 、 sodium hydroxide 作用下， 以 水 为溶剂， 反应 24.0h， 生成 2-[(Thien-2-ylmethoxy)methyl]oxirane
  参考文献：
  名称：

  Synthesis and Antibacterial Activity of Aromatic and Heteroaromatic Amino Alcohols

  摘要：

  Two series of aromatic and heteroaromatic amino alcohols were synthesized from alcohols and aldehydes and evaluated for their antibacterial activities. All the octylated compounds displayed a better activity against the four bacteria tested when evaluated by the agar diffusion method and were selected for the evaluation of minimal inhibitory concentration. The best results were obtained for p‐octyloxybenzyl derivatives against Staphylococcus epidermidis (minimal inhibitory concentrations = 32 μm).

  DOI：

  10.1111/j.1747-0285.2011.01231.x

文献信息

• Kinetic Resolution of Epoxides with CO ₂ Catalyzed by a Chiral‐at‐Iridium Complex
  作者：Jie Qin、Vladimir A. Larionov、Klaus Harms、Eric Meggers

  DOI：10.1002/cssc.201802049

  日期：2019.1.10

  Chiral‐at‐metal bis‐cyclometalated iridium(III) complexes are introduced as a new class of chiral catalysts for the reaction of epoxides with CO2 to form cyclic carbonates under conditions of kinetic resolution. Reactions are typically performed at room temperature in the presence of 1 mol % of iridium catalyst and 1.5 mol % of tetraethylammonium bromide as the nucleophilic cocatalyst to provide selectivity

  手性金属双环金属化铱（III）配合物被引入为一类新的手性催化剂，用于在动力学拆分条件下使环氧化物与CO 2反应形成环状碳酸酯。反应通常在室温下在作为亲核助催化剂的1摩尔％的铱催化剂和1.5摩尔％的四乙基溴化铵存在下进行，以提供至多16.6的选择性。发现各种单取代的环氧化物是合适的底物，包括苯乙烯环氧化物，具有脂族侧链的环氧化物，缩水甘油基醚和缩水甘油基酯。对于所研究的任何底物均未观察到聚合副反应。
• FLUORINE-CONTAINING ETHER COMPOUND, LUBRICANT FOR MAGNETIC RECORDING MEDIUM, AND MAGNETIC RECORDING MEDIUM
  申请人：SHOWA DENKO K.K.

  公开号：US20220048882A1

  公开（公告）日：2022-02-17

  The fluorine-containing ether compound is represented by the following formula (1): R 1 -R 2 —CH 2 —R 3 —CH 2 —R 4 . In the formula (1), R 1 is represented by the following formula (2), R 2 is represented by the following formula (3), R 3 is a perfluoropolyether chain, and R 4 is an organic end group different from R 1 -R 2 - and contains two or three polar groups, wherein each polar group is bonded to a different carbon atom, and the carbon atoms to which the polar groups are bonded are bonded to one another via a linking group containing a carbon atom to which the polar group is not bonded. In the formula (2), r is 1 to 3. In the formula (3), w is 2 or 3.
• [EN] FLUORINE-CONTAINING ETHER COMPOUND, MAGNETIC RECORDING MEDIUM LUBRICANT AND MAGNETIC RECORDING MEDIUM<br/>[FR] COMPOSÉ ÉTHER CONTENANT DU FLUOR, LUBRIFIANT POUR SUPPORT D'ENREGISTREMENT MAGNÉTIQUE ET SUPPORT D'ENREGISTREMENT MAGNÉTIQUE<br/>[JA] 含フッ素エーテル化合物、磁気記録媒体用潤滑剤および磁気記録媒体
  申请人：SHOWA DENKO KK

  公开号：WO2020054420A1

  公开（公告）日：2020-03-19

  式（１）で表される含フッ素エーテル化合物とする。Ｒ１－Ｒ２－ＣＨ２－Ｒ３－ＣＨ２－Ｒ４（１）（式（１）中、Ｒ１は式（２）、Ｒ２は式（３）で表され、Ｒ３はパーフルオロポリエーテル鎖。Ｒ４はＲ１－Ｒ２－と異なる有機末端基であって、２個または３個の極性基を含み、各極性基がそれぞれ異なる炭素原子に結合し、前記極性基の結合している炭素原子同士が、極性基の結合していない炭素原子を含む連結基を介して結合している末端基。式（２）中、ｒは１～３。式（３）中、ｗは２または３。）
• Synthesis and Antibacterial Activity of Aromatic and Heteroaromatic Amino Alcohols
  作者：Camila G. de Almeida、Samira G. Reis、Angelina M. de Almeida、Claudio G. Diniz、Vânia L. da Silva、Mireille Le Hyaric

  DOI：10.1111/j.1747-0285.2011.01231.x

  日期：2011.11

  Two series of aromatic and heteroaromatic amino alcohols were synthesized from alcohols and aldehydes and evaluated for their antibacterial activities. All the octylated compounds displayed a better activity against the four bacteria tested when evaluated by the agar diffusion method and were selected for the evaluation of minimal inhibitory concentration. The best results were obtained for p‐octyloxybenzyl derivatives against Staphylococcus epidermidis (minimal inhibitory concentrations = 32 μm).