4-(2-methyl-4-oxo-4H-quinazolin-3-yl)-butyric acid | 65452-94-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 4-(2-methyl-4-oxo-4H-quinazolin-3-yl)-butyric acid
• 英文别名: 4-(2-Methyl-4-oxo-3,4-dihydroquinazolin-3-yl)butanoic acid；4-(2-methyl-4-oxoquinazolin-3-yl)butanoic acid
• CAS: 65452-94-0
• 化学式: C₁₃H₁₄N₂O₃
• mdl: MFCD10666925
• 分子量: 246.266
• InChiKey: NVRKSNBKTRDUCB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.307
• 拓扑面积：
  70
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-(2-methyl-4-oxo-4H-quinazolin-3-yl)-butyric acid 在 氯化亚砜 作用下， 以 丙酮 为溶剂， 生成 4-(2-Methyl-4-oxoquinazolin-3-yl)butanoyl chloride
  参考文献：
  名称：

  Novel Approach for the Synthesis ofN-Substituted-4-(2-methyl-4-oxo-4H-quinazolin-3-yl)-butyramides

  摘要：

  [image omitted] A simple and convenient method for the synthesis of N-substituted-4-(2-methyl-4-oxo-4H-quinazolin-3-yl)-butyramides has been reported. Several aromatic and aliphatic amide derivatives of 4-(2-methyl-4-oxo-4H-quinazolin-3-yl)-butyric acid were prepared in 60-81% yields by refluxing it with different phosphazo compounds in toluene for approximately 1h.

  DOI：

  10.1080/00397911.2010.497594
• 作为产物：
  描述：

  邻乙酰胺苯甲酸內酯 、 4-氨基丁酸 以 乙醇 为溶剂， 反应 2.0h， 以70%的产率得到4-(2-methyl-4-oxo-4H-quinazolin-3-yl)-butyric acid
  参考文献：
  名称：

  Novel Approach for the Synthesis ofN-Substituted-4-(2-methyl-4-oxo-4H-quinazolin-3-yl)-butyramides

  摘要：

  [image omitted] A simple and convenient method for the synthesis of N-substituted-4-(2-methyl-4-oxo-4H-quinazolin-3-yl)-butyramides has been reported. Several aromatic and aliphatic amide derivatives of 4-(2-methyl-4-oxo-4H-quinazolin-3-yl)-butyric acid were prepared in 60-81% yields by refluxing it with different phosphazo compounds in toluene for approximately 1h.

  DOI：

  10.1080/00397911.2010.497594

文献信息

• Novel Approach for the Synthesis of<i>N</i>-Substituted-4-(2-methyl-4-oxo-4<i>H</i>-quinazolin-3-yl)-butyramides
  作者：Mohammad Amir、Israr Ali

  DOI：10.1080/00397911.2010.497594

  日期：2011.7.15

  [image omitted] A simple and convenient method for the synthesis of N-substituted-4-(2-methyl-4-oxo-4H-quinazolin-3-yl)-butyramides has been reported. Several aromatic and aliphatic amide derivatives of 4-(2-methyl-4-oxo-4H-quinazolin-3-yl)-butyric acid were prepared in 60-81% yields by refluxing it with different phosphazo compounds in toluene for approximately 1h.