4,6,4',6'-tetramethyl-5,5'-dimethoxydiphenic acid | 195984-02-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4,6,4',6'-tetramethyl-5,5'-dimethoxydiphenic acid
• 英文别名: 2-(6-Carboxy-3-methoxy-2,4-dimethylphenyl)-4-methoxy-3,5-dimethylbenzoic acid
• CAS: 195984-02-2
• 化学式: C₂₀H₂₂O₆
• 分子量: 358.391
• InChiKey: CCHBOESAZUIHJW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  93.1
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  甲醇 、 4,6,4',6'-tetramethyl-5,5'-dimethoxydiphenic acid 在 氯化亚砜 作用下， 以40%的产率得到5,5'-Dimethoxy-4,6,4',6'-tetramethyl-biphenyl-2,2'-dicarboxylic acid 2-methyl ester
  参考文献：
  名称：

  Synthesis of an Axially Dissymmetric Biphenylcarboxylate Ligand, BDME, and Asymmetric Cyclopropanation of Olefins with Diazoacetate Catalyzed by Its Dirhodium(II) Complex

  摘要：

  一种轴向不对称的二苯甲酸盐配体BDME（4）被新设计和制备。其与(4)的二铑(II)复合物(1)在与d-薄荷基二氮乙酸酯进行不对称环丙烷化反应中证实是一种优良的催化剂，生成了99%立体选择性的d-薄荷基顺式-2-苯基-环丙烷-1-羧酸盐。

  DOI：

  10.1055/s-1997-5777
• 作为产物：
  描述：

  4,6,4',6'-tetramethyl-5,5'-dimethoxydiphenate dimethyl ester 在 sodium hydroxide 、 水 、 盐酸 作用下， 以 甲醇 、 水 为溶剂， 反应 5.0h， 以100%的产率得到4,6,4',6'-tetramethyl-5,5'-dimethoxydiphenic acid
  参考文献：
  名称：

  EP1870403

  摘要：

  公开号：

文献信息

• OPTICALLY ACTIVE QUATERNARY AMMONIUM SALT HAVING AXIAL ASYMMETRY AND PROCESS FOR PRODUCING -AMINO ACID AND DERIVATIVE THEREOF WITH THE SAME
  申请人：NAGASE & COMPANY, LTD.

  公开号：EP1870403A1

  公开（公告）日：2007-12-26

  The present invention provides a chiral phase-transfer catalyst of the following formula (I): The compound (I) can be produced by reacting a 2,2'-dimethylene bromide-1,1'-biphenyl derivative, which can be produced through comparatively small number of steps, with an easily available secondary amine.

  本发明提供了下式（I）的手性相转移催化剂： 化合物(I)可通过 2,2'-二亚甲基溴-1,1'-联苯衍生物与易得的仲胺反应制得，该衍生物可通过相对较少的步骤制得。
• Optically active quaternary ammonium salt having axial asymmetry and process for producing alpha-amino acid and derivative thereof with the same
  申请人：NAGASE & COMPANY, LTD.

  公开号：EP2484667A1

  公开（公告）日：2012-08-08

  The present invention provides a chiral phase-transfer catalyst of the following formula (I): The compound (I) can be produced by reacting a 2,2'-dimethylene bromide-1,1'-biphenyl derivative, which can be produced through comparatively small number of steps, with an easily available secondary amine.

  本发明提供了下式（I）的手性相转移催化剂： 化合物(I)可通过 2,2'-二亚甲基溴-1,1'-联苯衍生物与易得的仲胺反应制得，该衍生物可通过相对较少的步骤制得。
• OPTICALLY ACTIVE QUATERNARY AMMONIUM SALT HAVING AXIAL ASYMMETRY AND PROCESS FOR PRODUCING ALPHA-AMINO ACID AND DERIVATIVE THEREOF WITH THE SAME
  申请人：Maruoka Keiji

  公开号：US20090270614A1

  公开（公告）日：2009-10-29

  The present invention provides a chiral phase-transfer catalyst of the following formula (I): The compound (I) can be produced by reacting a 2,2′-dimethylene bromide-1,1′-biphenyl derivative, which can be produced through comparatively small number of steps, with an easily available secondary amine.
• US8614316B2
  申请人：——

  公开号：US8614316B2

  公开（公告）日：2013-12-24
• Synthesis of an Axially Dissymmetric Biphenylcarboxylate Ligand, BDME, and Asymmetric Cyclopropanation of Olefins with Diazoacetate Catalyzed by Its Dirhodium(II) Complex
  作者：Hitoshi Ishitani、Kazuo Achiwa

  DOI：10.1055/s-1997-5777

  日期：1997.7

  An axially dissymmetric biphenylcarboxylate ligand, BDME (4), has been newly designed and prepared. The dirhodium(II) complex (1) of (4) proved to be an excellent catalyst in asymmetric cyclopropanation of styrene with d-menthyl diazoacetate affording d-menthyl cis-2-phenyl-cyclopropane-1-carboxylate of 99% de.

  一种轴向不对称的二苯甲酸盐配体BDME（4）被新设计和制备。其与(4)的二铑(II)复合物(1)在与d-薄荷基二氮乙酸酯进行不对称环丙烷化反应中证实是一种优良的催化剂，生成了99%立体选择性的d-薄荷基顺式-2-苯基-环丙烷-1-羧酸盐。