2,4,4'-trihydroxybiphenyl | 66624-11-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,4,4'-trihydroxybiphenyl
• 英文别名: 1-(4-hydroxyphenyl)-2,4-benzenediol；[1,1'-Biphenyl]-2,4,4'-triol；4-(4-hydroxyphenyl)benzene-1,3-diol
• CAS: 66624-11-1
• 化学式: C₁₂H₁₀O₃
• 分子量: 202.21
• InChiKey: CDABMPUGYTZWIY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  60.7
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2,4,4'-trihydroxybiphenyl 在 sodium phosphate dibasic dodecahydrate 、 potassium nitrososulfonate 作用下， 以 水 、 乙酸乙酯 为溶剂， 反应 20.0h， 以50%的产率得到5-(4-hydroxyphenyl)-2-hydroxy-2,5-cyclohexadiene-1,4-dione
  参考文献：
  名称：

  Structure-based design, synthesis and preliminary anti-inflammatory activity of bolinaquinone analogues

  摘要：

  As a part of our drug discovery efforts we developed a series of simplified derivatives of bolinaquinone (BLQ), a hydroxyquinone marine metabolite, showing potent anti-inflammatory activity. Thirteen new hydroxyquinone derivatives closely related to BLQ were synthesized and tested on mouse macrophagelike RAW 264.7 cell line in order to investigate their ability to modulate the production of Prostaglandin E-2 (PGE(2)). This optimization process led to the identification of three strictly correlated compounds with comparable and higher inhibitory potency than BLQ on PGE2 production. To evaluate the affinity of BLQ and its analogues for h5PLA(2), surface plasmon resonance (SPR) experiments were performed. (C) 2010 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2010.11.028
• 作为产物：
  描述：

  4-(2,4-二甲氧基苯基)苯酚 在 三溴化硼 、 水 作用下， 以 二氯甲烷 为溶剂， 反应 18.0h， 以80%的产率得到2,4,4'-trihydroxybiphenyl
  参考文献：
  名称：

  Structure-based design, synthesis and preliminary anti-inflammatory activity of bolinaquinone analogues

  摘要：

  As a part of our drug discovery efforts we developed a series of simplified derivatives of bolinaquinone (BLQ), a hydroxyquinone marine metabolite, showing potent anti-inflammatory activity. Thirteen new hydroxyquinone derivatives closely related to BLQ were synthesized and tested on mouse macrophagelike RAW 264.7 cell line in order to investigate their ability to modulate the production of Prostaglandin E-2 (PGE(2)). This optimization process led to the identification of three strictly correlated compounds with comparable and higher inhibitory potency than BLQ on PGE2 production. To evaluate the affinity of BLQ and its analogues for h5PLA(2), surface plasmon resonance (SPR) experiments were performed. (C) 2010 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2010.11.028

文献信息

• 1,3-Dihydroxybenzene derivatives and colorants containing said compounds
  申请人：——

  公开号：US20040016063A1

  公开（公告）日：2004-01-29

  1,3-Dihydroxybenzene derivatives of general formula (I) or (Ia) or physiologically tolerated, water-soluble thereof 1 wherein R′1 denotes substituted pyridyl group, a pyrimidyl group, a group of formula (IIa) or (IIIa) 2 and the dyeing agents for keratin fibers containing these compounds.

  一般式(I)或(Ia)的1,3-二羟基苯衍生物，或其生理耐受性、水溶性的衍生物，其中R′1代表取代吡啶基、嘧啶基、式(IIa)或(IIIa)的基团，以及含有这些化合物的角蛋白纤维染料剂。
• 비페닐 골격 함유 에폭시 수지의 제조 방법
  申请人：DIC Corporation 디아이씨 가부시끼가이샤(519986084017)

  公开号：KR20160008529A

  公开（公告）日：2016-01-22

  위치 선택적 크로스 커플링 반응을 포함하는 제조 공정에 의해 얻어진 다가 히드록시비페닐과, 에피할로히드린을 반응시키는 공정을 갖는 것을 특징으로 하는, 하기 식(1)으로 표시되는 비페닐 골격 함유 에폭시 수지의 제조 방법. (식 중, k1, l1은 각각 0〜4의 정수, m, n은 각각 1〜5의 정수를 나타내고, R 및 R는 각각 독립하여 치환기를 가지고 있어도 되는 탄소수 1〜10의 탄화수소기를 나타내고, R 및 R는 각각 서로 동일해도 달라도 된다(단, 비페닐 골격의 좌우의 각각의 페닐 구조는 다르다)).

  这是一种制备含有双酚骨架的环氧树脂的方法，其特征在于通过制造工艺包括选择性交叉耦合反应以获得对羟基联苯和环氧丙烯酸酯进行反应，如下所示（1）：（在该式中，k1、l1分别是0到4之间的整数，m、n分别表示1到5之间的整数，R和R分别表示可独立地具有取代基的碳数为1到10的烃基，R和R可以相同也可以不同（但是，联苯骨架的左右两个苯结构是不同的）。）
• BIS(AMINOPHENOL) DERIVATIVE, PROCESS FOR PRODUCING SAME, POLYAMIDE RESIN, POSITIVE PHOTOSENSITIVE RESIN COMPOSITION, PROTECTIVE FILM, INTERLAYER DIELECTRIC FILM, SEMICONDUCTOR DEVICE, AND DISPLAY ELEMENT
  申请人：Terakawa Koji

  公开号：US20100044888A1

  公开（公告）日：2010-02-25

  A bis(aminophenol) derivative having substituents at positions adjacent to two amino groups is provided. The bis(aminophenol) derivative is used as a raw material of a polyamide resin for a positive-tone photosensitive resin composition. A polyamide resin comprising bis(aminophenol) and a structure derived from a carboxylic acid is also provided, the bis(aminophenol) having substituents at positions adjacent to the two amino groups. A positive-tone photosensitive resin composition comprising a polybenzooxazole precursor resin, exhibiting high sensitivity and a high cyclization rate even when cured at a low temperature is provided. Also provided is a positive-tone photosensitive resin composition comprising a polyamide resin having an imide structure, an imide precursor structure, or an amide acid ester structure. The composition exhibits high sensitivity and produces a cured product having low water absorption even when cured at a low temperature.

  本发明提供了一种在两个氨基团相邻位置上具有取代基的双(氨基酚)衍生物。该双(氨基酚)衍生物用作聚酰胺树脂的原材料，用于制备正向感光树脂组合物。还提供了一种聚酰胺树脂，包括双(氨基酚)和由羧酸衍生的结构，其中双(氨基酚)在两个氨基团相邻位置上具有取代基。提供了一种正向感光树脂组合物，包括聚苯并噁唑前体树脂，即使在低温下固化，也表现出高灵敏度和高环化速率。还提供了一种正向感光树脂组合物，包括具有酰亚胺结构、酰亚胺前体结构或酰胺酸酯结构的聚酰胺树脂。该组合物表现出高灵敏度，即使在低温下固化，也能产生低吸水性的固化产物。
• Process for producing dihydric phenols
  申请人：DAINIPPON INK AND CHEMICALS, INC.

  公开号：EP0468477A1

  公开（公告）日：1992-01-29

  A process for producing dihydric phenols is disclosed. The process comprises reacting a phenol with a ketone peroxide or a combination of a ketone and hydrogen peroxide in the presence of a compound having at least one P-S bond. Dihydric phenols can be produced in high yield without requiring neutralization after the reaction.

  本发明公开了一种生产二水酚的工艺。该工艺包括在至少有一个 P-S 键的化合物存在下，使苯酚与过氧化酮或酮与过氧化氢的组合发生反应。反应后无需中和，即可高产制得二水苯酚。
• BIS(AMINOPHENOL) DERIVATIVE, PROCESS FOR PRODUCING THE SAME, POLYAMIDE RESIN, POSITIVE PHOTOSENSITIVE RESIN COMPOSITIONS, PROTECTIVE FILM, INTERLAYER DIELECTRIC, SEMICONDUCTOR DEVICE, AND DISPLAY ELEMENT
  申请人：Sumitomo Bakelite Company, Ltd.

  公开号：EP2077291A1

  公开（公告）日：2009-07-08

  A bis(aminophenol) derivative having substituents at positions adjacent to two amino groups is provided. The bis(aminophenol) derivative is used as a raw material of a polyamide resin for a positive-tone photosensitive resin composition. A polyamide resin comprising bis(aminophenol) and a structure derived from a carboxylic acid is also provided, the bis(aminophenol) having substituents at positions adjacent to the two amino groups. A positive-tone photosensitive resin composition comprising a polybenzooxazole precursor resin, exhibiting high sensitivity and a high cyclization rate even when cured at a low temperature is provided. Also provided is a positive-tone photosensitive resin composition comprising a polyamide resin having an imide structure, an imide precursor structure, or an amide acid ester structure. The composition exhibits high sensitivity and produces a cured product having low water absorption even when cured at a low temperature:

  本发明提供了一种双（氨基苯酚）衍生物，其取代基位于两个氨基的相邻位置。双（氨基苯酚）衍生物可用作正色调感光树脂组合物聚酰胺树脂的原料。还提供了一种由双（氨基苯酚）和衍生自羧酸的结构组成的聚酰胺树脂，双（氨基苯酚）在邻近两个氨基的位置上具有取代基。本发明提供了一种包含聚苯并恶唑前体树脂的正色调光敏树脂组合物，即使在低温固化时也能表现出高灵敏度和高环化率。还提供了一种正色调感光树脂组合物，该组合物由具有亚胺结构、亚胺前体结构或酰胺酸酯结构的聚酰胺树脂组成。该组合物具有高灵敏度，即使在低温下固化，也能产生低吸水性的固化产品：