(-)-5-benzyl-7-(tert-butoxycarbonylamino)-7-methyl-5-azaspiro[2.4]heptane

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (-)-5-benzyl-7-(tert-butoxycarbonylamino)-7-methyl-5-azaspiro[2.4]heptane
• 英文别名: 5-Benzyl-7-t-butoxycarbonylamino-7-methyl-5-azaspiro[2.4]heptane；tert-butyl N-(5-benzyl-7-methyl-5-azaspiro[2.4]heptan-7-yl)carbamate
• 化学式: C₁₉H₂₈N₂O₂
• 分子量: 316.444
• InChiKey: TZOHXOZJLUQRMF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.63
• 拓扑面积：
  41.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (-)-5-benzyl-7-(tert-butoxycarbonylamino)-7-methyl-5-azaspiro[2.4]heptane 在 palladium 10% on activated carbon 氢气 作用下， 以 甲醇 、 水 为溶剂， 反应 5.0h， 以100%的产率得到(-)-7-(tert-butoxycarbonylamino)-7-methyl-5-azaspiro[2.4]heptane
  参考文献：
  名称：

  WO2006/123792

  摘要：

  公开号：
• 作为产物：
  描述：

  二碳酸二叔丁酯 、 7-amino-5-benzyl-7-methyl-5-azaspiro[2.4]heptane 以 水 、 甲苯 为溶剂， 反应 19.0h， 以82%的产率得到(-)-5-benzyl-7-(tert-butoxycarbonylamino)-7-methyl-5-azaspiro[2.4]heptane
  参考文献：
  名称：

  WO2006/123767

  摘要：

  公开号：

文献信息

• Tri-, tetra-substituted-3-aminopyrrolidine derivative
  申请人：Takahashi Hisashi

  公开号：US20060264428A1

  公开（公告）日：2006-11-23

  A quinolone synthetic antibacterial agent and a therapeutic agent for an infection which exhibit broad spectrum and strong antibacterial activity for both Gram positive and Gram negative bacteria, and which are also highly safe are provided. The compound provided is represented by following formula (I): wherein R 1 and R 2 represent hydrogen atom, or the like; R 3 represents an alkyl group containing 1 to 6 carbon atoms, or the like; R 4 and R 5 independently represents hydrogen atom, an alkyl group containing 1 to 6 carbon atoms, or the like, with the proviso that R 4 and R 5 do not simultaneously represent hydrogen atom; or the substituents R 4 and R 5 together represent (a) a 3- to 6-membered cyclic structure including the carbon atom shared by R 4 and R 5 to form a spirocyclic structure with the pyrrolidine ring; R 6 and R 7 independently represents hydrogen atom, an alkyl group containing 1 to 6 carbon atoms, or the like; R 8 represents a halogen-substituted alkyl group containing 1 to 6 carbon atoms, or the like; X 1 represents hydrogen atom or a halogen atom; A represents nitrogen atom or a moiety represented by formula (II):

  提供了一种喹诺酮合成抗菌剂和治疗感染的药物，对革兰氏阳性和革兰氏阴性细菌均表现出广谱和强效的抗菌活性，并且具有很高的安全性。所提供的化合物由以下式（I）表示： 其中R1和R2代表氢原子，或类似物；R3代表含有1至6个碳原子的烷基基团，或类似物；R4和R5独立地代表氢原子，含有1至6个碳原子的烷基基团，或类似物，但R4和R5不同时代表氢原子；或取代基R4和R5一起代表（a）包括由R4和R5共享的碳原子形成螺环结构与吡咯烷环形成螺环结构的3至6成员环结构；R6和R7独立地代表氢原子，含有1至6个碳原子的烷基基团，或类似物；R8代表含有1至6个碳原子的卤代烷基基团，或类似物；X1代表氢原子或卤原子；A代表氮原子或由式（II）表示的基团。
• TRI-, TETRA-SUBSTITUTED-3-AMINOPYRROLIDINE DERIVATIVE
  申请人：TAKAHASHI Hisashi

  公开号：US20090253726A1

  公开（公告）日：2009-10-08

  A quinolone synthetic antibacterial agent and a therapeutic agent for an infection which exhibit broad spectrum and strong antibacterial activity for both Gram positive and Gram negative bacteria, and which are also highly safe are provided. The compound provided is represented by formula (I):

  提供了一种喹诺酮合成抗菌剂和治疗感染的药物，具有广谱和强大的抗菌活性，对革兰氏阳性和革兰氏阴性细菌均有作用，并且非常安全。所提供的化合物由式（I）表示。
• METHOD FOR PRODUCING ASYMMETRIC TETRASUBSTITUTED CARBON ATOM-CONTAINING COMPOUND
  申请人：Tani Yuichiro

  公开号：US20090054648A1

  公开（公告）日：2009-02-26

  The invention provides an industrial method for producing a spiroaminopyrrolidone derivative, which is an intermediate for producing a quinolone antibacterial agent. The invention provides a method for producing a compound represented by formula (2): (wherein n is an integer of 2 to 5; R 1 represents a (substituted) alkyl group or a (substituted) aryl group; and R 2 represents a (substituted) alkoxycarbonyl group, a (substituted) aralkyloxycarbonyl group, a (substituted) aliphatic acyl group, or a (substituted) aromatic acyl group), which includes treating a compound represented by formula (1): (wherein n, R 1 , and R 2 are the same as defined above; and R 3 represents a hydrogen atom, a (substituted) alkyl group, or a (substituted) aralkyl group) under a hydrogen gas atmosphere in the presence of a metallic catalyst.

  本发明提供了一种工业方法，用于生产螺环氨基吡咯烷衍生物，该衍生物是生产喹诺酮类抗菌剂的中间体。本发明提供了一种生产由式（2）表示的化合物的方法：（其中n是2至5的整数；R1表示（取代）烷基或（取代）芳基；R2表示（取代）烷氧羰基，（取代）芳基烷氧羰基，（取代）脂肪酰基或（取代）芳香酰基），其包括在金属催化剂存在下，在氢气气氛下处理由式（1）表示的化合物：（其中n，R1和R2如上定义；R3表示氢原子，（取代）烷基或（取代）芳基烷基）。
• PROCESS FOR PREPARATION OF TETRASUBSTITUTED 5-AZASPIRO[2.4]- HEPTANE DERIVATIVES AND OPTICALLY ACTIVE INTERMEDIATES THEREOF
  申请人：Takahashi Hisashi

  公开号：US20090270637A1

  公开（公告）日：2009-10-29

  The present invention provides a method for effectively producing an optically active form of tetrasubstituted-5-azaspiro[2.4]heptane derivative, which serves as a useful production intermediate for quinolonecarboxylic acid antibacterial agents, and intermediates for the derivative. The present invention is directed to a method for producing a compound (VII) according to the following scheme.

  本发明提供了一种有效生产四取代-5-氮杂螺[2.4]庚烷衍生物的光学活性形式的方法，该方法作为喹诺酸类抗菌剂的有用生产中间体以及该衍生物的中间体。本发明是针对按照以下方案生产化合物（VII）的方法。
• Method for Production of Quinolone-Containing Lyophilized Preparation
  申请人：Nishimoto Norihiro

  公开号：US20080300403A1

  公开（公告）日：2008-12-04

  The present invention is directed to a lyophilized preparation which contains a synthetic quinolone antibacterial compound and, as a solo additive, a pH-adjusting agent, and which exhibits an excellent reconstituting property. The invention provides a method for producing a lyophilized preparation containing a synthetic quinolone antibacterial compound as an active ingredient, characterized by including, sequentially, cooling an aqueous solution containing a synthetic quinolone antibacterial compound and a pH-adjusting agent to yield a frozen product, elevating the temperature of the frozen product, and re-cooling the resultant to prepare the lyophilized preparation.

  本发明涉及一种冻干制剂，其包含合成喹诺酮类抗菌化合物和一个pH调节剂作为单一添加剂，并表现出优异的重构性能。本发明提供了一种制备含有合成喹诺酮类抗菌化合物作为活性成分的冻干制剂的方法，其特征在于依次包括将含有合成喹诺酮类抗菌化合物和pH调节剂的水溶液冷却以产生冻结产物，提高冻结产物的温度，然后再次冷却以制备冻干制剂。