bis(4-methylthiobenzyl)diselenide | 1255907-89-1

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: bis(4-methylthiobenzyl)diselenide
• 英文别名: 1-Methylsulfanyl-4-[[(4-methylsulfanylphenyl)methyldiselanyl]methyl]benzene
• CAS: 1255907-89-1
• 化学式: C₁₆H₁₈S₂Se₂
• 分子量: 432.371
• InChiKey: ASWVWOUKSZIJTB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.15
• 重原子数：
  20
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  50.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-(甲基硫醇)溴化苯 在 sodium tetrahydroborate 作用下， 以 乙醇 、 丙酮 为溶剂， 反应 2.0h， 生成 bis(4-methylthiobenzyl)diselenide
  参考文献：
  名称：

  Selenocyanates and diselenides: A new class of potent antileishmanial agents

  摘要：

  Thirty five selenocyanate and diselenide compounds were subjected to in vitro screening against Leishmania infantum promastigotes and the most active ones were also tested in an axenic amastigote model. In order to establish the selectivity indexes (SI) the cytotoxic effect of each compound was also assayed against Jurkat and THP-1 cell lines.Thirteen derivatives exhibit better IC50 values than miltefosine and edelfosine. Bis(4-aminophenyl) diselenide exhibits the best activity when assayed in infected macrophages and one of the lowest cytotoxic activities against the human cell lines tested, with SI values of 32 and 24 against Jurkat and THP-1 cells, respectively. This compound thus represents a new lead for further studies aimed at establishing its mechanism of action. (C) 2011 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2011.04.054

文献信息

• Selenocyanates and diselenides: A new class of potent antileishmanial agents
  作者：Daniel Plano、Ylenia Baquedano、David Moreno-Mateos、María Font、Antonio Jiménez-Ruiz、Juan Antonio Palop、Carmen Sanmartín

  DOI：10.1016/j.ejmech.2011.04.054

  日期：2011.8

  Thirty five selenocyanate and diselenide compounds were subjected to in vitro screening against Leishmania infantum promastigotes and the most active ones were also tested in an axenic amastigote model. In order to establish the selectivity indexes (SI) the cytotoxic effect of each compound was also assayed against Jurkat and THP-1 cell lines.Thirteen derivatives exhibit better IC50 values than miltefosine and edelfosine. Bis(4-aminophenyl) diselenide exhibits the best activity when assayed in infected macrophages and one of the lowest cytotoxic activities against the human cell lines tested, with SI values of 32 and 24 against Jurkat and THP-1 cells, respectively. This compound thus represents a new lead for further studies aimed at establishing its mechanism of action. (C) 2011 Elsevier Masson SAS. All rights reserved.