(diselanediylbis(4,4-phenylene))dimethanol | 1620199-12-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (diselanediylbis(4,4-phenylene))dimethanol
• 英文别名: (diselanediylbis(4,1-phenylene))dimethanol；(Diselanediylbis(4,1-phenylene))dimethanol；[4-[[4-(hydroxymethyl)phenyl]diselanyl]phenyl]methanol
• CAS: 1620199-12-3
• 化学式: C₁₄H₁₄O₂Se₂
• 分子量: 372.184
• InChiKey: STSCJOQVRHOSDM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.05
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-溴苄醇 在 sodium diselenide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 4.0h， 生成 (diselanediylbis(4,4-phenylene))dimethanol
  参考文献：
  名称：

  利用可见光诱导交联的普鲁兰多糖载药系统 及其制备方法

  摘要：

  本发明提供一种利用可见光诱导交联的普鲁兰多糖载药系统的制备方法，包括如下步骤：1)制备双硒化合物；2)制备含有双硒化合物的普鲁兰载体；3)将去盐酸化阿霉素与普鲁兰载体分别溶于DMSO，混合，透析，可见光辐照，诱导交联，得到负载阿霉素的天然普鲁兰多糖载药系统。本发明的纳米载药系统将普鲁兰‑双硒化合物作为载体，实现对阿霉素的载药，并且利用可见光诱导交联，提高了纳米载药系统的稳定性，使得纳米载药系统在体内稳定安全地将药物靶向递送到病灶部位。

  公开号：

  CN108371713B

文献信息

• Metal-free synthesis of diselenides and ditellurides by using TMSCN
  作者：Chuan-Li Chen、Jin-Cheng Li、Miao-Chang Liu、Yun-Bing Zhou、Hua-Yue Wu

  DOI：10.1016/j.tetlet.2022.154255

  日期：2022.12

  A metal-free protocol is disclosed for C-Se and Se-Se bonds forming reactions between boronic acids and elemental selenium to synthesize diselenides by using TMSCN as an organic catalyst. Meanwhile, a series of ditellurides were obtained from boronic acids and elemental tellurium with TMSCN. Preliminary mechanistic studies reveal that the reaction involved a radical way.

  公开了一种无金属方案，用于通过使用 TMSCN 作为有机催化剂在硼酸和元素硒之间形成 C-Se 和 Se-Se 键形成反应以合成二硒化物。同时，用TMSCN从硼酸和单质碲中得到了一系列二碲化物。初步的机理研究表明，该反应涉及激进的方式。
• An investigation of in vitro cytotoxicity and apoptotic potential of aromatic diselenides
  作者：Masood Ahmad Rizvi、Santosh Guru、Tahira Naqvi、Manjeet Kumar、Navanath Kumbhar、Showkat Akhoon、Shazia Banday、Shashank K. Singh、Shashi Bhushan、G. Mustafa Peerzada、Bhahwal Ali Shah

  DOI：10.1016/j.bmcl.2014.05.075

  日期：2014.8

  A target synthesis of a library of symmetric aromatic diselenides was attempted with the aim of generating anticancer lead compounds. Out of thirteen screened molecules (1-13) against a panel of human cancer cell lines, compound 8 exhibited highest cell growth inhibition in Human leukemia HL-60 cells with IC50 value of 8 mu M. Compound 8 had a good pro-apoptotic potential as evidenced from several apoptotic protocols like DNA cell cycle analysis and monitoring of apoptotic bodies formation using phase contrast and nuclear microscopy with Hoechst 33,258. Also, 8 significantly inhibits S phase of the cell cycle and eventually trigger apoptosis in HL-60 cells through mitochondrial dependent pathway substantiated by the loss of mitochondrial potential. A theoretical investigation of DNA binding ability of 8 showed that it selectively bind to minor groove of DNA, where it is stabilized by hydrogen bonding and hydrophobic interactions. (C) 2014 Elsevier Ltd. All rights reserved.